Q1QTK7

PR
Gene name
hisS
Protein name
Histidine--tRNA ligase
Names
Histidyl-tRNA synthetase, HisRS
Species
Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11)
KEGG Pathway
csa:Csal_2855
EC number
6.1.1.21: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

377-428 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1QTK7

Entry ID Method Resolution Chain Position Source
AF-Q1QTK7-F1 Predicted AlphaFoldDB

No variants for Q1QTK7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1QTK7

No associated diseases with Q1QTK7

4 regional properties for Q1QTK7

Type Name Position InterPro Accession
domain Anticodon-binding 345 - 423 IPR004154
domain Aminoacyl-tRNA synthetase, class II 1 - 330 IPR006195
domain Histidyl-anticodon-binding 329 - 415 IPR033656
domain Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain 10 - 312 IPR041715

Functions

Description
EC Number 6.1.1.21 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

1 GO annotations of biological process

Name Definition
histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSNKIQAIRG MNDLLPEQSP VWQYFERQIQ HLMQRYGYNE IRTPILEQTA LFKRSIGEVT
70 80 90 100 110 120
DIVEKEMYTF EDRNGDSLTL RPEGTASCVR AALENGLLYN QTQRLWYQGP MFRHERPQKG
130 140 150 160 170 180
RYRQFHQVGV EAYGMLGPDI DFEMILLSAR LWDALGLMPH VRLELNSLGS SEARAAYRDA
190 200 210 220 230 240
LVAYFEAHAE VLDEDSRRRL TSNPLRILDS KNPDMAEMLE AAPRLMDHLD DESRAHFEQL
250 260 270 280 290 300
TAMLDAAGID YVINPRLVRG LDYYSRTVFE WTTQALGSQG TVCAGGRYDG LVEQLGGKPT
310 320 330 340 350 360
PGVGFAMGVE RLILLLETLD LVPEAARSRP DVYLTAMGDT ASREAMLLGE HLRDALPEMH
370 380 390 400 410 420
LQVHCGGGSF KSQIKKADKS GARIALMLGD DEIASGSVGI KFLREDREQE SVAREALAAR
LQALLAED