Q1MRT4

PR
Gene name
mutS
Protein name
DNA mismatch repair protein MutS
Names
Species
Lawsonia intracellularis (strain PHE/MN1-00)
KEGG Pathway
lip:LI0236
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

795-880 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1MRT4

Entry ID Method Resolution Chain Position Source
AF-Q1MRT4-F1 Predicted AlphaFoldDB

No variants for Q1MRT4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1MRT4

No associated diseases with Q1MRT4

5 regional properties for Q1MRT4

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 631 - 823 IPR000432
domain DNA mismatch repair protein MutS-like, N-terminal 9 - 120 IPR007695
domain DNA mismatch repair protein MutS, core 276 - 614 IPR007696
domain DNA mismatch repair protein MutS, connector domain 130 - 257 IPR007860
domain DNA mismatch repair protein MutS, clamp 452 - 541 IPR007861

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNESSHRITP MLEQYLSIKS NYPDTLLFYR MGDFYELFFE DAETAARELQ IALTARNPRA
70 80 90 100 110 120
ENPVPMCGVP WHAADSYIHQ LIQKGYKVAL CEQTEDFRES KGLVQRKVTR VFTSATTTEE
130 140 150 160 170 180
TSLDPKTHTY LGAMYWDEEV NIGAFCWADV STGLWTGIQV KKKSELWQWI QKILPKELLF
190 200 210 220 230 240
PEKYELPATA KLIEIQFVPL PYKTHFEYPQ AVKRLLQAQG VADLEALGLE KHTILVQACG
250 260 270 280 290 300
ALVAYLEQTQ LQDVNHLMPF KPLDIGKYVI LDEITEKNLE LFKRVNGKKG VGTLIHVLDH
310 320 330 340 350 360
TLTPMGGRLL EERLHHPWRD ITTILENQSV LEWLILYKEN MKKLQDALKA IYDLERLSTR
370 380 390 400 410 420
IVLNRTSPKD LLALKNTLLI LPRVKDALIV EINVKDNRYI TIDESILSTM PTILRQLLTK
430 440 450 460 470 480
WDNISDYAEK LDKALDENPP NSIVEGGLFK LGFNAELDEL MDLLEHGESK LQALLEKEQK
490 500 510 520 530 540
VNNLPRLKIG FNRVFGYYFE LTKSAGTPPS HFVRRQTLAN AERYTTEELK DLEERLLSAT
550 560 570 580 590 600
EKRNTLEYKL FQKLREELVS IRPRILFMAS LIAQLDLWQS LADVAIRHNW NKPTLLTNNN
610 620 630 640 650 660
IFIREGRHPV IESIIGKSVF VPNDLVMDET RRMLLITGPN MAGKSTVLRQ TAIICLLAHM
670 680 690 700 710 720
GSFVPATEAQ IGICDRIFSR VGASDNLARG QSTFMVEMME TARILRQATS RSLVILDEIG
730 740 750 760 770 780
RGTSTFDGLA LAWAVAEDLV CKDHDGVRTL FATHYHELTA LEEKLTGVHT MTIAIRHWND
790 800 810 820 830 840
ELVFLYRLIP GPADRSYGIE VARLAGVPQS VIQRAKIILT QLEQTHQQPR SLLNLLPGVV
850 860 870 880 890
QNANEELSKQ DVKVVEHPVV TLLKEMNPET LTPLDALKSL VEWKLLYGTT HAT