Q1LQ59

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans)
KEGG Pathway
rme:Rmet_0831
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

393-473 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1LQ59

Entry ID Method Resolution Chain Position Source
AF-Q1LQ59-F1 Predicted AlphaFoldDB

No variants for Q1LQ59

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1LQ59

No associated diseases with Q1LQ59

4 regional properties for Q1LQ59

Type Name Position InterPro Accession
domain DHHA1 domain 733 - 870 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 653 - 695 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 554 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 708 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKVSDIRSKF LQFFESKGHT VVRSSSLVPA NDPTLLFTNS GMVQFKDVFL GTDKRPYVRA
70 80 90 100 110 120
TSSQRSVRAG GKHNDLENVG YTARHHTFFE MLGNFSFGDY FKREAIQYAW ELLTKVYQLP
130 140 150 160 170 180
ADKLWVTVYA EDDEAYDIWA KEVGVPADRI VRIGDNKGAR YASDNFWQMA DTGPCGPCSE
190 200 210 220 230 240
IFYDHGPDVW GGPPGSPEED GDRYIEIWNL VFMQFNRDEQ GTMTPLPKPC VDTGMGLERI
250 260 270 280 290 300
AAVLQHVHSN YEIDLFQALI KGAGRETHIA DLNQNSLKVI ADHIRACSFL IVDGVIPGNE
310 320 330 340 350 360
GRGYVLRRIV RRAIRHGYKL GQKTPFFHKL VGDLVAQMGE AYPELAEAQS RVVEVLKAEE
370 380 390 400 410 420
ERFFETIENG MSILDAAVAD LKAKGGKVLD GELAFKLHDT FGFPLDLTQD VAREQEITVD
430 440 450 460 470 480
EAAFDAAMTR QREQARAAGK FKMAAGLEYS GEKTVFHGYD ALSMDGVRVT ALYVDGASVD
490 500 510 520 530 540
TMQPGQSGVV VLDNTPFYAE SGGQVGDQGT LVSGPAVFAV ADTTKIQSDV FGHQGTLANG
550 560 570 580 590 600
ALKVGDTVAA QVDAVRRART VRNHSATHLM HKALREVLGT HVQQKGSLVD PDKTRFDFSH
610 620 630 640 650 660
NAPLTDAQIR QIEEIVNAEI LSNAPTVAQV MPFDDAVKSG AMALFGEKYA DDVRVLSIGT
670 680 690 700 710 720
SKELCGGTHV TRTGDIGLFK IVVEAGVAAG IRRVEAITGD NALHYLQSLD ARLNEAAAAL
730 740 750 760 770 780
RAQPSELVPR IGQVQDQVRA LEKELEKLKS KLASSQGDEL AAQAVDVKGL KVLAAQLDGA
790 800 810 820 830 840
DVKTLRETMD KLKDKLQSAA IVLAAVADGK VSLIAGVTAD ATSKVKAGEL VNFVAQQVGG
850 860 870
KGGGRPDMAQ AGGTDPANLP KALAGVTEWV SAKV