Q1LK00
Gene name |
kynA |
Protein name |
Tryptophan 2,3-dioxygenase |
Names |
TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase |
Species |
Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) (Ralstonia metallidurans) |
KEGG Pathway |
rme:Rmet_2651 |
EC number |
1.13.11.11: With incorporation of two atoms of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q1LK00
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2NOX | X-ray | 240 A | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P | 19-299 | PDB |
| AF-Q1LK00-F1 | Predicted | AlphaFoldDB |
No variants for Q1LK00
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q1LK00 | |||||
No associated diseases with Q1LK00
No regional properties for Q1LK00
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q1LK00 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 1.13.11.11 | With incorporation of two atoms of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| catalytic complex | A protein complex which is capable of catalytic activity. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| identical protein binding | Binding to an identical protein or proteins. |
| metal ion binding | Binding to a metal ion. |
| tryptophan 2,3-dioxygenase activity | Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| NAD biosynthetic process | The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. |
| quinolinate biosynthetic process | The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid. |
| tryptophan catabolic process to kynurenine | The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSEFKGCPMG | HGAAPQNGDG | GDSGDTGNGW | HGAQMDFARD | MSYGDYLGLD | QILSAQHPLS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PDHNEMLFIV | QHQTTELWMK | LMLHELRAAR | DGVKSDQLQP | AFKMLARVSR | IMDQLVQAWN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VLATMTPPEY | SAMRPYLGAS | SGFQSYQYRE | IEFILGNKNA | AMLRPHAHRP | EHLELVETAL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HTPSMYDEAI | RLMARRGFQI | DPEVVERDWT | QPTQYNASVE | AAWLEVYRNP | SAHWELYELG |
| 250 | 260 | 270 | 280 | 290 | |
| EKFVDLEDAF | RQWRFRHVTT | VERVIGFKRG | TGGTEGVSYL | RRMLDVVLFP | ELWKLRTDL |