Q1L8F9

PR
Gene name
kics2 (si:ch211-125a15.1, zgc:136251)
Protein name
KICSTOR subunit 2
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:555715
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

77-204 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1L8F9

Entry ID Method Resolution Chain Position Source
AF-Q1L8F9-F1 Predicted AlphaFoldDB

No variants for Q1L8F9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1L8F9

No associated diseases with Q1L8F9

No regional properties for Q1L8F9

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q1L8F9

Functions

Description
EC Number
Subcellular Localization
  • Lysosome membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
KICSTOR complex A protein complex that regulates the TORC1 signaling pathway in response to nutrients. The KICSTOR complex is composed of KPTN, ITFG2, C12orf66 and SZT2.
lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
cellular response to amino acid starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
cellular response to glucose starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
negative regulation of TORC1 signaling Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.
protein localization to lysosome A process in which a protein is transported to, or maintained in, a location within a lysosome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MCDPQRDEEL RPVPKERAVL ESFFTQLGMF WFDRAKDYVE KEKDASKSAG AIWGSLLAAL
70 80 90 100 110 120
AHLAAAEKAY HNMTFLGQKL GGQSFFSRKD SIRTIYTSLH NELKKVVSMG RHAPGGSTPN
130 140 150 160 170 180
LEELLPHLSE QLCHFTQARM EIADFYEKMH TLGSQKTVNS EELVGALDSI LQKYSSRFHH
190 200 210 220 230 240
PILSRLESSF QVEVDVLTQL LRCQAQISEW HFLPSLLNLH GAHSKLQAWG QVFERQRETR
250 260 270 280 290 300
KHLFGGQSQK AVQPPHLFLW LQRLQATLLA KFSFYFHEAL SRQTSQSEMK TLTARTSLDY
310 320 330 340 350 360
FGKISGFIRK YDASNVSLVF DNRGSESFQG HGYHHPQSYR EAPKGVDQFP AVVSLPGGER
370 380 390 400 410 420
PVTHWPNVIM IMSDRSTELN TLDKVVHFYD DKVQSTYFLA RPEPHFTIVV IFDGRKSERD
430 440
SYIVAFLQEL IGSLRNSKPF TSLKPGSKG