Q1KKS3
Gene name |
pde11a |
Protein name |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
Names |
cAMP and cGMP phosphodiesterase 11A |
Species |
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) |
KEGG Pathway |
|
EC number |
3.1.4.35: Phosphoric diester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q1KKS3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q1KKS3-F1 | Predicted | AlphaFoldDB |
No variants for Q1KKS3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q1KKS3 | |||||
No associated diseases with Q1KKS3
5 regional properties for Q1KKS3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 542 - 866 | IPR002073 |
| domain | GAF domain | 175 - 334 | IPR003018-1 |
| domain | GAF domain | 356 - 522 | IPR003018-2 |
| domain | HD/PDEase domain | 617 - 793 | IPR003607 |
| conserved_site | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | 658 - 669 | IPR023174 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.4.35 | Phosphoric diester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3',5'-cyclic-AMP phosphodiesterase activity | Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+. |
| 3',5'-cyclic-GMP phosphodiesterase activity | Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+. |
| metal ion binding | Binding to a metal ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| metabolic process | The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAVPKMVFSD | VESFLDSHPE | LFEDYLNRKG | SSSMVEKWLK | NHQAGKSEAE | PKEEKSSVCK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DSWASKCDGL | QRRASQKELR | KTFARSKAIN | VNRTYDEHVN | SRAQEPLTSM | RRRALLRKAS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLPPTTAHIL | SALLESRVNI | PQYPSTAVDF | KYYLKEHNER | EFFLELVKDI | SNDLDLTSLS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YKILVFVCIM | VDADRCSLFL | VEGTGNKKTL | VSKFFDVHAG | TTVLPSMNSG | EVQVPWGKGI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IGYVAEHGET | VNIPDAYQDR | RFSDEIDKLT | GYKTKSLLCM | PIQNSDGEII | GVAQAINKSS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SGELFTEDDE | KVLQMYLPFC | GIAISNAQLF | AASRKEYDRS | RALLEVVNDL | FEEQTDLEKI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VRKIMHRAQT | LLKCERCSVQ | LLEDIESPVV | KFTKSFELLS | PKCSADAESS | FKDSMEKSSY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SDWLINNSIA | ELVASTGLPV | NISDAYQDPR | FDAEADQFSD | FHIRSVLCVP | IWNSNHQIIG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VAQVLNRLDG | KPFDDADQRL | FEAFVIFCGL | GINNTIMYDQ | VKKSWAKQSV | ALDVLSYHAT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| CSKTEVDKFK | AANIPLVCEL | GIDKLSFDDF | SLDVDAMITA | ALRMFIELGM | VQKFKIDYET |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LCRWLLTVRK | NYRMVLYHNW | RHAFNVCQCM | FAMLTTAGFQ | ETLTDVEILA | LIVGCVCHDL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DHRGTNNAFQ | AKTGSALSLL | YGTSATLEHH | HFNHAVMILQ | SEGHNIFCNL | SSTEYSDLMQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LLKQSILATD | LTLYFENRNS | FFELVSIGEY | NWNVKTHRDM | CRSMMMTACD | LGAVTKPWDI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SRKVAELVTS | EFFEQGDRER | SELKLTPSAI | FDRNRKDELP | GLQLEWIDGI | CAPLYETLVK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LNPKLQPMVD | MINANRVKWE | ELDKKRQHDH | GASVPASPCS | AAEGSETGGV | PCCSNNTPPT |
| HVS |