Q1K8G0

PR
Gene name
met-2 (NCU07987.1)
Protein name
Cystathionine beta-lyase
Names
Cysteine-S-conjugate beta-lyase
Species
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
KEGG Pathway
ncr:NCU07987
EC number
4.4.1.13: Carbon-sulfur lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-70 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1K8G0

Entry ID Method Resolution Chain Position Source
AF-Q1K8G0-F1 Predicted AlphaFoldDB

No variants for Q1K8G0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1K8G0

No associated diseases with Q1K8G0

No regional properties for Q1K8G0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q1K8G0

Functions

Description
EC Number 4.4.1.13 Carbon-sulfur lyases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
carbon-sulfur lyase activity Catalysis of the elimination of hydrogen sulfide or substituted H2S.
cystathionine beta-lyase activity Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate.
cystathionine gamma-lyase activity Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+.
cysteine-S-conjugate beta-lyase activity Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

3 GO annotations of biological process

Name Definition
'de novo' L-methionine biosynthetic process The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid, from simpler components.
cysteine biosynthetic process via cystathionine The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine.
transsulfuration The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTPNSDSPA AQAAKKVFSR LDLDGHNLPP SPAPSSPHNG RRYALATELV YTETKDQYGA
70 80 90 100 110 120
SSIPIYQSAT FKQSSSNGGS EYDYTRSGNP TRTHLERHLA KIMNANRCLS VSSGMGALDV
130 140 150 160 170 180
ITRLLKPGDE VITGDDLYGG TNRLLTYLKN NQGVIVHHVD TTNVESVRQI ISPKTTMVLL
190 200 210 220 230 240
ETPTNPLIKI CDIPTIARIT HEANEKAVVV VDNTMLSPML FNPLDVGADI VYESGTKYLS
250 260 270 280 290 300
GHHDIMAGVI AVNDTELGDK LYFTINATGC GLSPNDSFLL MRGVKTLAIR MEKQQANAQR
310 320 330 340 350 360
IAEFLESHGF KVRYPGLKSH PQYDLHWSMA RGAGAVLSFE TGDVALSERI VEAARLWGIS
370 380 390 400 410 420
VSFGCVNSLI SMPCRMSHAS IDAKTRAERQ MPEDIIRLCV GIEDADDLID DLSRALVQAG
430 440 450
AVTLTVDGFH ANTAEGAAAA AAGSEAAETT TTAAPSL