Q1JKF1

PR
Gene name
serS
Protein name
Serine--tRNA ligase
Names
Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
Species
Streptococcus pyogenes serotype M12 (strain MGAS9429)
KEGG Pathway
spk:MGAS9429_Spy1485
EC number
6.1.1.11: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

23-99 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1JKF1

Entry ID Method Resolution Chain Position Source
AF-Q1JKF1-F1 Predicted AlphaFoldDB

No variants for Q1JKF1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1JKF1

No associated diseases with Q1JKF1

8 regional properties for Q1JKF1

Type Name Position InterPro Accession
domain Kazal domain 117 - 166 IPR002350-1
domain Kazal domain 190 - 241 IPR002350-2
domain Kazal domain 261 - 318 IPR002350-3
domain Follistatin-like, N-terminal 94 - 117 IPR003645-1
domain Follistatin-like, N-terminal 167 - 190 IPR003645-2
domain Follistatin-like, N-terminal 244 - 268 IPR003645-3
domain Follistatin/Osteonectin EGF domain 95 - 116 IPR015369
domain TB domain 30 - 91 IPR017878

Functions

Description
EC Number 6.1.1.11 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).

3 GO annotations of biological process

Name Definition
selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.
selenocysteinyl-tRNA(Sec) biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA
seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLDLKRIRTD FDTVAAKLKN RGVSEDTLTH LKELDEKRRT LLVQSEELKA ERNIASAAIA
70 80 90 100 110 120
QAKRQKEDAT QQIADMQKVS ADIKTIDNQL VAIDQQVTDI ITVLPNTPHD SVPVGADEED
130 140 150 160 170 180
NVEIRRWGTP RDFNFEVKAH WDLGEDLDIL DWERGAKVTG ARFLFYKNLG ARLERALYNF
190 200 210 220 230 240
MLDEHIKEGY QEIITPYMVN HDSMFGTGQY PKFKEDTFEL ADTNFVLIPT AEVPLTNYYR
250 260 270 280 290 300
GEILDGKELP IYFTAMSPSF RSEAGSAGRD TRGLIRLHQF HKVEMVKFAK PEESYQELEK
310 320 330 340 350 360
MTANAENILQ KLGLPYRVIS LCTGDMGFSA AKTYDLEVWI PAQNTYREIS SCSNTEDFQA
370 380 390 400 410 420
RRAQIRYRDE ADGKVKLLHT LNGSGLAVGR TVAAILENYQ NEDGSVTIPE VLRPYMGGET
VISPK