Q1J0P6
Gene name |
rpoB |
Protein name |
DNA-directed RNA polymerase subunit beta |
Names |
RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta |
Species |
Deinococcus geothermalis (strain DSM 11300 / AG-3a) |
KEGG Pathway |
dge:Dgeo_0636 |
EC number |
2.7.7.6: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q1J0P6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q1J0P6-F1 | Predicted | AlphaFoldDB |
No variants for Q1J0P6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q1J0P6 | |||||
No associated diseases with Q1J0P6
7 regional properties for Q1J0P6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA-directed RNA polymerase, subunit 2, hybrid-binding domain | 620 - 1059 | IPR007120 |
| conserved_site | RNA polymerase, beta subunit, conserved site | 868 - 880 | IPR007121 |
| domain | RNA polymerase Rpb2, domain 7 | 1061 - 1135 | IPR007641 |
| domain | RNA polymerase Rpb2, domain 2 | 150 - 302 | IPR007642 |
| domain | RNA polymerase, beta subunit, protrusion | 24 - 400 | IPR007644 |
| domain | RNA polymerase Rpb2, domain 3 | 415 - 483 | IPR007645 |
| domain | DNA-directed RNA polymerase, beta subunit, external 1 domain | 493 - 558 | IPR019462 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.6 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| DNA-directed RNA polymerase complex | A protein complex that possesses DNA-directed RNA polymerase activity. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-directed 5'-3' RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
| ribonucleoside binding | Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated transcription | The synthesis of an RNA transcript from a DNA template. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLTDQKPRI | ERFGEITEVI | PLPNLTEVQV | NSFKAFLQAD | KAPDERDDTG | LQSAFREVFP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IDETEKGRST | GLVLDFLEYR | LGEPPYTPEE | CREKDLTYQA | PLYAKLQLIH | KDSGLIKEDQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VFLGDLPLMT | DDGSFVINGA | DRVVISQIHR | SPGVYFTSSY | KGIKKMYTAA | IIPMPKRGPW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IELEFNGGVL | EMKVNKRKFP | VSLLLRVLGY | DDAQLKALFT | EFDPAAELPE | DKSAGMNPDE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ALLRLFTVLR | PGDPPKRDKA | IQYLYGLLAD | PKRYDLGEPG | RFKMNTKLGT | RRQDRTLLTF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EDGRFGDAGL | VDTIRYLMAL | QQGLETVTMG | ADEDGVAIEV | PVTEDDIDHL | GNRRVRTVGE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LLADQLRVGM | GRMARGVRER | MLLGNPDAAT | PTKLVNNRPI | VAAMREFFGR | SQLSQFKDQT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NPLSDLRHKR | RISALGPGGL | TRERAGFDVR | DVHRTHYGRI | CPIETPEGAN | IGLISSLSSY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AKVNDLGFIE | APYRRVVDGR | VTDDVVYMTA | DIEDRYVIAQ | ANSPLNPDGT | FAEERVLARK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KGDPMLYAPT | EVDFMDVSPK | QIVSINTSLI | PFLEHDDANR | ALMGSNMQSQ | AVPLVRADSP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AVGTGVEERV | VTDSGTSVIS | DVTGRVTYVD | ARAIQVTLTE | DAPQIGLVKG | NVRTFELVRF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TRSNQGTNLD | QHPIVSVGDE | VVPGQVIADG | PASDQGRLAL | GQNITIAIMP | FDGFNFEDAI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| CISEGLVRKD | FYTSVHIEKD | EIEARDTKLG | PEKITRDIPG | LSEAALRDLD | EDGIVRVGAE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VKPGDILVGK | TSFKGESEPT | PEERLLRSIF | GEKAREVKDT | SLRVQSGQGG | IVVKTVRFRR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GDEGVDLKPG | VREMVRVYVA | QKRQLQVGDK | VANRHGNKGV | VSKILPPEDM | PYLEDGTPVD |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LVFNPLGVPS | RMNLGQILET | HLGEVARLTG | QKFVTPVFDS | ATEEAIKEML | EVAAAERLQR |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| RKDEGFELDK | REQEVLDRAG | KLGVISPPNG | DYAAAQMQLA | RTGKSVLYDG | RTGEPISGPV |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| VVGTMYVMKL | YHMVEDKLHA | RSTGPYSLIT | QQPLGGKAQF | GGQRFGEMEV | WALEAYGAAH |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| TLQEMLTIKS | DDIDGRDAAY | QSIVKGEEVS | GSTIPESFKV | LVKELHSLGL | DVEVLDNNDK |
| 1150 | |||||
| PVDIFEGMMP | KR |