Q1IWM5

PR
Gene name
argH
Protein name
Argininosuccinate lyase
Names
ASAL, Arginosuccinase
Species
Deinococcus geothermalis (strain DSM 11300 / AG-3a)
KEGG Pathway
dge:Dgeo_2065
EC number
4.3.2.1: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

403-465 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1IWM5

Entry ID Method Resolution Chain Position Source
AF-Q1IWM5-F1 Predicted AlphaFoldDB

No variants for Q1IWM5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1IWM5

No associated diseases with Q1IWM5

3 regional properties for Q1IWM5

Type Name Position InterPro Accession
conserved_site Fumarate lyase, conserved site 284 - 293 IPR020557
domain Fumarate lyase, N-terminal 13 - 309 IPR022761
domain Argininosuccinate lyase, C-terminal 372 - 439 IPR029419

Functions

Description
EC Number 4.3.2.1 Lyases acting on amides, amidines, etc
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
argininosuccinate lyase activity Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.

1 GO annotations of biological process

Name Definition
arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTNTTQDKKL WGGRFAEATD GLVELFNASV AFDQRLAEQD IRGSLAHVAM LGQTGILTPD
70 80 90 100 110 120
EVAQIEEGLQ GILADIRAGR FDWRLDREDV HMNVEAALRD RIGPVAGKLH TARSRNDQVA
130 140 150 160 170 180
VDFRLFTKEA ALDLAAKVRA LRAVLVAEAE KHLQDEVILP GYTHLQVAQP ILLSHWLMAY
190 200 210 220 230 240
AAMLERDEGR FRDAAERMDE SPLGSSALAG TPWPIDRFAT AAALGFARPT ANSLDGVGSR
250 260 270 280 290 300
DFALEFLSAC AILAAHLSRL SEELILYSTF EFGFLTLPDS HTTGSSIMPQ KKNPDVAELA
310 320 330 340 350 360
RGKAGRVFGN LMGLLTVVKG TPLAYNKDLQ EDKEGVFDSY DTLSIVLRLY ADMLPKTVWH
370 380 390 400 410 420
ADVTKLAAAR GFSTATDLAD FLARSGVPFR EAHEVVGRLV GLASRTGRQL WDLTDEELRA
430 440 450 460
AHPLLSAEVA RALTVEESVK SRRSYGGTAP ERVREQVAAA KAALS