Q1I4X3

PR
Gene name
metE
Protein name
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Names
Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme
Species
Pseudomonas entomophila (strain L48)
KEGG Pathway
pen:PSEEN4639
EC number
2.1.1.14: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

362-468 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1I4X3

Entry ID Method Resolution Chain Position Source
AF-Q1I4X3-F1 Predicted AlphaFoldDB

No variants for Q1I4X3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1I4X3

No associated diseases with Q1I4X3

2 regional properties for Q1I4X3

Type Name Position InterPro Accession
domain Cobalamin-independent methionine synthase MetE, C-terminal/archaeal 434 - 757 IPR002629
domain Cobalamin-independent methionine synthase MetE, N-terminal 4 - 316 IPR013215

Functions

Description
EC Number 2.1.1.14 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
methylation The process in which a methyl group is covalently attached to a molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALAHNLGFP RIGRDRELKK AQEAYWKGEL DEAGLCAVGR GLRAAHWQAQ KAAGIELLPV
70 80 90 100 110 120
GDFAWYDQVL THSLTFGVIP ERFRAKDGAK PTLQTLFAMA RGVSDSCCGG AHAQEMTKWF
130 140 150 160 170 180
DTNYHYLVPE FTADQQFALS WEQLFEEVEE AKALGHAVKP VVIGPLTYLW LGKTKGADFD
190 200 210 220 230 240
KLELLDRLLP LYDQILNRLA VQGVEWVQID EPILALDLPQ DWKNAYERVY NILQRAPLKK
250 260 270 280 290 300
LIATYFGGLE DNLGLAANLP VDGLHIDLVR APDQYPTILD RLPAYKVLSL GVVNGRNVWR
310 320 330 340 350 360
CDLEKALEVL RHAHERLGDR LWVAPSCSLL HSPVDLARED KLDDELKSWL AFAVQKCQEV
370 380 390 400 410 420
ALLAKAINQP EAADVVTVLA QSRAVQHRRA TSPRIHKPAV QARVAAIKPA DSQRATAFEQ
430 440 450 460 470 480
RIAKQRAGLD LPAFPTTTIG SFPQTSAIRL ARQSFKQGKL TEADYVEAMH SEIRHAVEIQ
490 500 510 520 530 540
ENLGLDVLVH GEAERNDMVE YFAEQLDGYV FTRFGWVQSY GSRCVKPAVI FGDLSRPKAM
550 560 570 580 590 600
TVEWIKYAQG LTRKAMKGML TGPVTMLMWS FPREDVTREV QARQLALAIR DEVVDLEAAG
610 620 630 640 650 660
IKIVQIDEAA FREGLPLRRS AWPHYLEWAT EAFRLCASDV RDETQIHTHM CYSEFNDVIE
670 680 690 700 710 720
SIAAMDADVI TIETSRSDME LLEAFERFDY PNEIGPGVYD IHSPRVPTKE EMVKLLRKAA
730 740 750 760
QRIPAERLWV NPDCGLKTRA WPETEAALVN MVAAARELRA TA