Q1HRV8

PR
Gene name
AAEL008004
Protein name
Elongation of very long chain fatty acids protein AAEL008004
Names
3-keto acyl-CoA synthase AAEL008004, Very-long-chain 3-oxoacyl-CoA synthase AAEL008004
Species
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
KEGG Pathway
EC number
2.3.1.199: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

241-315 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1HRV8

Entry ID Method Resolution Chain Position Source
AF-Q1HRV8-F1 Predicted AlphaFoldDB

No variants for Q1HRV8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1HRV8

No associated diseases with Q1HRV8

No regional properties for Q1HRV8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q1HRV8

Functions

Description
EC Number 2.3.1.199 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
fatty acid elongase activity Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C).
very-long-chain 3-ketoacyl-CoA synthase activity Catalysis of the reaction: malonyl-CoA + a very-long-chain 2,3,4-saturated fatty acyl CoA = carbon dioxide + coenzyme A + a very-long-chain oxoacyl-CoA.

1 GO annotations of biological process

Name Definition
fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALIMKYIDS MHHYMDKYGD PRTKDWPLMS SPFPTLALCL GYVYLVKVLG PRLMENRKPF
70 80 90 100 110 120
QLRNTLILYN FVQVVFSAWL FYEIGISGWL TGHYNFRCQP VDYSNHPKTL RMVHACWWYY
130 140 150 160 170 180
FSKFTEFFDT FFFVMRKKTS QVSTLHVIHH GCMPMSVWFG VKFTPGGHST FFGLLNTFVH
190 200 210 220 230 240
IVMYTYYLFT AMGPQFQKYL WWKKYLTSLQ MVQFVAIMVH AFQLLFIDCN YPKAFVWWIG
250 260 270 280 290 300
MHAVMFLFLF NEFYQSTYKA TKRRRAAAAE ARRLAAEEAK LQNGSAVSSN GSAITANGHH
310 320 330 340 350
GKNGSVHHHS NGSATSNGTS LLSNGVGSNK AADYYVRGDL PAEIEITQRQ PSSRNQVQ