Q1H3L5

PR
Gene name
cysG
Protein name
Siroheme synthase
Names
Species
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
KEGG Pathway
mfa:Mfla_0652
EC number
1.3.1.76: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

169-238 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1H3L5

Entry ID Method Resolution Chain Position Source
AF-Q1H3L5-F1 Predicted AlphaFoldDB

No variants for Q1H3L5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1H3L5

No associated diseases with Q1H3L5

6 regional properties for Q1H3L5

Type Name Position InterPro Accession
domain Tetrapyrrole methylase 218 - 427 IPR000878
conserved_site Uroporphiryn-III C-methyltransferase, conserved site 296 - 329 IPR003043
domain Uroporphyrin-III C-methyltransferase 216 - 451 IPR006366
domain Sirohaem synthase, N-terminal 4 - 206 IPR006367
domain Sirohaem synthase, dimerisation domain 151 - 207 IPR019478
domain Siroheme synthase, central domain 119 - 144 IPR028281

Functions

Description
EC Number 1.3.1.76 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
precorrin-2 dehydrogenase activity Catalysis of the reaction: NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin.
sirohydrochlorin ferrochelatase activity Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin.
uroporphyrin-III C-methyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2.

3 GO annotations of biological process

Name Definition
cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
methylation The process in which a methyl group is covalently attached to a molecule.
siroheme biosynthetic process The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
METLPIFMKL RDRPCLVVGG GEIASRKVSL LEKAGASVTV VSPELHPTLA KSLAEGRIRH
70 80 90 100 110 120
LASVFEPAQL DGAVLVIAAT DDAEVNRAVS REAQARNIPV NVVDAPELCT FIVPSIVDRS
130 140 150 160 170 180
PLLVAVSSGG TAPVLARMLR TRIETLIPAT YGRLAAFAAE FREAVKQRFS TGQQRRIFWE
190 200 210 220 230 240
DVFQGVIGEQ VLSGQEEAAR HAMQQVLSGR GELHHGEVYL VGGGPGDPDL LTFRALRLMQ
250 260 270 280 290 300
QADVCVYDKL VSKEVMALVR RDAELIYVGK SRDQHTLPQE DINQLLVRLA KEGKRVLRLK
310 320 330 340 350 360
GGDPFIFGRG GEEIETLMEN GIPFQVVPGI TAANGVSSYA GIPLTHRDYA QSCLFTTGHL
370 380 390 400 410 420
KDGSVNLDWD ALVRPNQTVV IYMGLVGLPE ICRQMVAHGA PENLPIAIVQ QGTTQRQRVV
430 440 450 460
EGTLATLPGL VERAGLRAPC LIIVGQVVRL REKLAWFAPS PEVVSAG