Q1H361

PR
Gene name
iscS
Protein name
Cysteine desulfurase IscS
Names
Species
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
KEGG Pathway
mfa:Mfla_0808
EC number
2.8.1.7: Sulfurtransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

200-274 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1H361

Entry ID Method Resolution Chain Position Source
AF-Q1H361-F1 Predicted AlphaFoldDB

No variants for Q1H361

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1H361

No associated diseases with Q1H361

2 regional properties for Q1H361

Type Name Position InterPro Accession
domain Aminotransferase class V domain 7 - 369 IPR000192
binding_site Aminotransferase class-V, pyridoxal-phosphate binding site 198 - 217 IPR020578

Functions

Description
EC Number 2.8.1.7 Sulfurtransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
2 iron, 2 sulfur cluster binding Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
cysteine desulfurase activity Catalysis of the reaction: L-cysteine
metal ion binding +Binding to a metal ion.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

1 GO annotations of biological process

Name Definition
[2Fe-2S] cluster assembly The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTVRTPIYLD YSATTPIDPR VAEKMIPYLT EHFGNPASRS HAFGWTAEKA VENAREEVAR
70 80 90 100 110 120
LVNADPREIV WTSGATESNN LAIKGAANFY SPSKGKHIVT VQTEHKAVID TVRELERLGY
130 140 150 160 170 180
EATYLIPEPN GLIDLDKFKA ALRPDTVLAS VMLVNNEIGV IQDIEAIGNI CREQGVIFHV
190 200 210 220 230 240
DAAQATGKVH IDLQKLPVDL MSFSAHKTYG PKGIGALYVR RKPRVRIEAQ MHGGGHERGM
250 260 270 280 290 300
RSGTLATHQI VGMGEAFRIA REEMDSENVR IRQLRDRLLK GLQEIEEVYV NGDLEHRVAH
310 320 330 340 350 360
NLNISFNFVE GESLIMAVKD IAVSSGSACT SASLEPSYVL RALGRSDELA HSSIRFSIGR
370 380 390 400
FTTEEEIDYT IQLMKSKIGK LRELSPLWEM HLEGVDLNAV AWATH