Q1H2P1

PR
Gene name
mutS2
Protein name
DNA mismatch repair protein MutS
Names
Species
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
KEGG Pathway
mfa:Mfla_0978
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

795-879 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1H2P1

Entry ID Method Resolution Chain Position Source
AF-Q1H2P1-F1 Predicted AlphaFoldDB

No variants for Q1H2P1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1H2P1

No associated diseases with Q1H2P1

5 regional properties for Q1H2P1

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 636 - 826 IPR000432
domain DNA mismatch repair protein MutS-like, N-terminal 42 - 153 IPR007695
domain DNA mismatch repair protein MutS, core 302 - 621 IPR007696
domain DNA mismatch repair protein MutS, connector domain 162 - 286 IPR007860
domain DNA mismatch repair protein MutS, clamp 458 - 549 IPR007861

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MHGEHDRGGV IIKVCDDVLA LAGKHERAIN LTKLDNTLEQ HTPMMRQYLG IKAQYPDMLV
70 80 90 100 110 120
FYRMGDFYEL FHDDAEKASR LLGITLTKRG SSNGEPIRMA GVPYHAAEQY LAKLAKLGEA
130 140 150 160 170 180
VAICEQVGDP AKSKGPVERQ VTRILTPGTL TDAALLDDTR DNLLLAIAHG EGVLGLARIN
190 200 210 220 230 240
LASGRFILSE ITPGLLAQEL ERISPAEILY PDDFYHMALE QVKCPKKRLA PWQFDLDSSI
250 260 270 280 290 300
QTLTKQFSTY DLDGFGCAHM LAAIMAAGAL LDYVKHTQRT SLPHIQSLMV EQGSQFIQLD
310 320 330 340 350 360
AATRRNLEID QTLRGESSPT LYSLLNTTVT AMGARLLRSW LHHPLQHQAD IQARLQAVKV
370 380 390 400 410 420
LQAQYDGLRP LLRNVGDIER MAARVALKTA RPRDLSGLRD SLQQLPALQR VLRPEDSALL
430 440 450 460 470 480
HSLQQQLDVP QAALDMLIAA IKDEPAAVLR EGGVIADGFD AELDELRAIQ SNCGEFLLQF
490 500 510 520 530 540
EAQERERSGI SNLKVEYNSV HGFYIEISRA QSENVPAEYR RRQTLKNVER YITPELKTFE
550 560 570 580 590 600
DKVLSANERA LAREKFLFDE LLGNLQPALA AWQRNAEAVA QLDVLATFAE RADVLKYVAP
610 620 630 640 650 660
QFSSEAGLDI VDGRHPVVEQ LAQPFIANSV SLSPYRQLLL ITGPNMGGKS TYMRQTALIV
670 680 690 700 710 720
LLAHCGCFVP AKSARIGPID RIFTRIGASD DLAGGRSTFM VEMTETANIL HNATERSLVL
730 740 750 760 770 780
LDEIGRGTST FDGLSLAWAV ARQLLEKNRS YTLFATHYFE LTRISEEFKH AANVHLDAVE
790 800 810 820 830 840
HGDGIVFLHN VEEGPASQSY GLQVAQLAGI PRTVVNAAKR KLVQLEQSQV MQQSLAGQGD
850 860 870 880
MFVAANVEPE PATHPVVSEL ESIDPDSLTP RQALDVLYKL KKLI