Q1H1W4

PR
Gene name
purT
Protein name
Formate-dependent phosphoribosylglycinamide formyltransferase
Names
5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2
Species
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
KEGG Pathway
mfa:Mfla_1255
EC number
6.3.1.21: Acid--ammonia (or amine) ligases (amide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

350-400 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1H1W4

Entry ID Method Resolution Chain Position Source
AF-Q1H1W4-F1 Predicted AlphaFoldDB

No variants for Q1H1W4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1H1W4

No associated diseases with Q1H1W4

3 regional properties for Q1H1W4

Type Name Position InterPro Accession
domain NAD-dependent epimerase/dehydratase 18 - 79 IPR001509
domain ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type 123 - 300 IPR003135
domain ATP-grasp fold 119 - 314 IPR011761

Functions

Description
EC Number 6.3.1.21 Acid--ammonia (or amine) ligases (amide synthases)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ligase activity Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
magnesium ion binding Binding to a magnesium (Mg) ion.
phosphoribosylglycinamide formyltransferase 2 activity Catalysis of the reaction: formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate.
phosphoribosylglycinamide formyltransferase activity Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide.

1 GO annotations of biological process

Name Definition
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNIGTPLSPV ATRVMLLGSG ELGKEVIIAL QRLGVEVIAV DRYQNAPGHQ VAHRAYAIDM
70 80 90 100 110 120
TDPVALRELI DKENPHLIVP EIEALNTQLL AEVELAGHTR VVPTVKAVQL TMNREGIRRL
130 140 150 160 170 180
AAEELKLPTS PYAFADSEQS LRTAIESGIG YPCFIKPTMS SSGKGQSRIT SPEQIAAAWE
190 200 210 220 230 240
YAATAGRVNQ GKVIVEGQID FDYEITLLTV RALDAEGKVE TSFCEPIGHL QEKGDYVESW
250 260 270 280 290 300
QPQPMTALAL GRAQEIARAV TESLGGLGLF GVELFVKGDQ VWFSEVSPRP HDTGMVTMGS
310 320 330 340 350 360
QRFSEFDLHA RAILGLPVNV ALSRPGASAV IYGGLDSSQL VFEGVEQALA VPESDIRLFG
370 380 390
KPESFARRRM GVALATADDV EKARARARTA AKLVKTRDGK