Q1GVA9

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
KEGG Pathway
sal:Sala_0692
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

214-288 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1GVA9

Entry ID Method Resolution Chain Position Source
AF-Q1GVA9-F1 Predicted AlphaFoldDB

No variants for Q1GVA9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1GVA9

No associated diseases with Q1GVA9

7 regional properties for Q1GVA9

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 348 - 555 IPR002314
domain TGS 3 - 64 IPR004095
domain Anticodon-binding 568 - 657 IPR004154
domain Aminoacyl-tRNA synthetase, class II 252 - 561 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 176 - 228 IPR012947
domain Threonine-tRNA ligase catalytic core domain 252 - 566 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 566 - 656 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDMIRVTLP DGSAREVARG TTPAEIAAAI GPGLAKAALA AKIDGELRDI MRPLEEDTNL
70 80 90 100 110 120
ALVTSRDEAD ALELARHDYA HVLAEAVQTL FPGTQITFGP ATSDGFYYDF APTAEHGPFR
130 140 150 160 170 180
DEELPLIEEE MRRIIAADKP LRREVWDRDA LIARWKKDGE TFKAEWAAEL PAGEEISVYW
190 200 210 220 230 240
SGDDWMDMCR GPHLASTGKL DPAAFKLTRV SGAYWRGDQK NAQLSRIYGT GWLNRKQLAE
250 260 270 280 290 300
HLVRLEEAAK RDHRRLGQEM DLFHLQQEAH GSVFWHPNGF VVWRELEAYM RRAIDAAGYR
310 320 330 340 350 360
EVKTPQVMDA RQWEQSGHWG KYRENMFVIP DEVPNTEDEG PIVSDDAEWM ALKPMNCPAH
370 380 390 400 410 420
VLIFRQGMKS YRDLPLRLYE NGCCHRNEPH GALHGLMRVR QFTQDDAHIF CREDQIVEEV
430 440 450 460 470 480
RNFCALADRI YKDFGFTYAI KLALRPEKRF GSDAMWDKSE DELRNAVIEA GLATEQYGWE
490 500 510 520 530 540
ELPGEGAFYA PKLEWHLTDA IGRTWQVGTI QSDRVLPDRL DASYIGEDGE RHRPVMLHRA
550 560 570 580 590 600
IFGSYERFIG ILIEHFVGRF PTWLAPVQAV VATIVSDADD YAKAATARLV AAGIRTESDL
610 620 630 640 650 660
RNEKINYKVR EHSLAKVPHL LVVGKREAEE GTVAIRTLGQ DGQRIMPLAE AIAMLKTQAT
PPDLKVR