Q1GV98
Gene name |
rlmN |
Protein name |
Dual-specificity RNA methyltransferase RlmN |
Names |
23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase |
Species |
Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis) |
KEGG Pathway |
sal:Sala_0703 |
EC number |
2.1.1.192: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q1GV98
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q1GV98-F1 | Predicted | AlphaFoldDB |
No variants for Q1GV98
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q1GV98 | |||||
No associated diseases with Q1GV98
1 regional properties for Q1GV98
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Radical SAM | 121 - 388 | IPR007197 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.192 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| metal ion binding | Binding to a metal ion. |
| rRNA (adenine-C2-)-methyltransferase activity | Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + rRNA containing C2-methyladenine(2503) in 23S rRNA. |
| rRNA binding | Binding to a ribosomal RNA. |
| tRNA (adenine-C2-)-methyltransferase activity | Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(37) in tRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + C2-methyladenine(37) in a tRNA. |
| tRNA binding | Binding to a transfer RNA. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| rRNA base methylation | The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQIPGHIDPV | TTGTVPLRGG | NRIDLVGLSR | DAIGGVLVEA | GLDAKAAKLR | AKQIWHWIYH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RGVTDFMGMT | DIAKAMRPWL | TDRFIIGRPT | VREAQVSSDG | TRKWLLAAAD | GQEYEMVFIP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DADRGTLCVS | SQVGCTLNCR | FCHTGTMRLV | RNLGAGEIVG | QVLLARDALG | EWPKGNMAGF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GAGSDADPED | DDADDDAVGH | YTADGRMLTN | IVMMGMGEPL | YNFDEVKAAL | KIVMDGDGLA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSKRRITLST | SGVVPMMARA | GEEIGVNLAV | SLHAVSKEIR | DEIVPLNRKY | GIEELLQACA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DYPGANNARR | ITFEYVMLKD | KNDRDEDARE | LVRLIKQYKL | PAKVNLIPFN | PWPGAPYECS |
| 370 | 380 | 390 | 400 | 410 | |
| TPERVRAFSN | LIFKAGISAP | IRTPRGRDIM | AACGQLKSAA | TRPTRAELDR | IAEEKQAALG |