Q1GIY4

PR
Gene name
rimO
Protein name
Ribosomal protein S12 methylthiotransferase RimO
Names
S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO
Species
Ruegeria sp (strain TM1040) (Silicibacter sp)
KEGG Pathway
sit:TM1040_0649
EC number
2.8.4.4: Transferring alkylthio groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-61 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1GIY4

Entry ID Method Resolution Chain Position Source
AF-Q1GIY4-F1 Predicted AlphaFoldDB

No variants for Q1GIY4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1GIY4

No associated diseases with Q1GIY4

5 regional properties for Q1GIY4

Type Name Position InterPro Accession
domain TRAM domain 400 - 467 IPR002792
domain Elp3/MiaA/NifB-like, radical SAM core domain 158 - 389 IPR006638
domain Radical SAM 26 - 466 IPR007197
domain Methylthiotransferase, N-terminal 27 - 137 IPR013848
domain RimO, TRAM domain 403 - 465 IPR041582

Functions

Description
EC Number 2.8.4.4 Transferring alkylthio groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
metal ion binding Binding to a metal ion.
protein methylthiotransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + a

2 GO annotations of biological process

Name Definition
peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid The modification of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid, typical of bacterial ribosomal protein S12.
tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSNPPDLRP DLAPKPTFGT APRPDQPTLG MVSLGCPKAL VDSERILTRL RAEGYGISAD
70 80 90 100 110 120
YAGADAVIVN TCGFLDSAKA ESLEAIGEAL KENGKVIVTG CLGAEPDYIR EHHPRILAVT
130 140 150 160 170 180
GPHQYEQVLD AVHAAVPPSP DPFVDLLPAT GVSLTPRHFS YLKISEGCNH KCKFCIIPDM
190 200 210 220 230 240
RGKLASRPAH AVLREAEKLV TAGVRELLVI SQDTSAYGLD RKYDVNPWKD GEVRSHITDL
250 260 270 280 290 300
SRALGELAPA DQLWVRLHYV YPYPHVRELI PLMADPENAV LPYLDIPFQH AHPDVLRRMA
310 320 330 340 350 360
RPAAAAKTLD EIRAWRAICP DITLRSTFIV GYPGETEAEF QHLLDWMDEA QLDRVGCFKY
370 380 390 400 410 420
ENVDGARSND LPDHVAEEVK QNRWERFMEK AQAISEAKLA SKVGQTLQVI VDEIDEDGIA
430 440 450 460
TCRTKADAPE IDGNLFIDEG TANLSVGDLV TVEVDEAGEY DLWGALR