Q1G9P3

PR
Gene name
proS
Protein name
Proline--tRNA ligase
Names
Prolyl-tRNA synthetase, ProRS
Species
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM 00102 / Lb 14)
KEGG Pathway
ldb:Ldb1338
EC number
6.1.1.15: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

171-288 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1G9P3

Entry ID Method Resolution Chain Position Source
AF-Q1G9P3-F1 Predicted AlphaFoldDB

No variants for Q1G9P3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1G9P3

No associated diseases with Q1G9P3

6 regional properties for Q1G9P3

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 94 - 457 IPR002314
domain Anticodon-binding 476 - 562 IPR004154
domain Aminoacyl-tRNA synthetase, class II 33 - 466 IPR006195
domain YbaK/aminoacyl-tRNA synthetase-associated domain 257 - 375 IPR007214
domain Prokaryote proline-tRNA ligase core domain 17 - 456 IPR033730
domain Proline--tRNA ligase, anticodon binding domain 471 - 561 IPR044140

Functions

Description
EC Number 6.1.1.15 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
proline-tRNA ligase activity Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

1 GO annotations of biological process

Name Definition
prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRQSIFFMPT LKETPADAVA KSHQVMLRGG YIRQVTAGVY SYLPLGYKVL RKTEKIIEEE
70 80 90 100 110 120
MANAGVVEMI MPHMLPASMW EESGRLPKYG PEMFRLKDRH GREMLLGPTH EETFTDVVAK
130 140 150 160 170 180
SLKSYKQMPL QLYQIQTKFR DENRPRFGLL RGREFVMLDG YSFAASQEQL DKQFDDEKAA
190 200 210 220 230 240
YLKIFKRTGV EVRPVIADSG TMGGKNSIEF QAPAAVGEDT IATNASGTYA ANLEMAVSVD
250 260 270 280 290 300
TFKQEPEELK AMEKVATPGC DSIDKLAEFL QVPATRIVKS VLYIVDEKKK VLVLIRADKE
310 320 330 340 350 360
VNEVKLTHLL DCDSLRVAET SDLEELTGAG KGGVGPVNAD WADEIVADKT VKGLYNVVVG
370 380 390 400 410 420
AGESDAQFIN ANLDRDFRAD RFADLRVANE GEPDPVDHEP LKFTTSIEVG HIFKLGTYYT
430 440 450 460 470 480
ETMGAKFLDQ NGKSQPVIMG SYGIGVTRLL SAVVEQHATE NGVAWPKEIA PFGIHIIQMK
490 500 510 520 530 540
MKDEIQSKLA EDLEAKFAKY DVLYDDRNER PGVKFNDADL VGAPIRITVG RDAADGIVEV
550 560
KRPGDDQAQK LAVADLEDFI ANELD