Q1EB31

PR
Gene name
DBP4 (CIMG_00232)
Protein name
ATP-dependent RNA helicase DBP4
Names
Species
Coccidioides immitis (strain RS) (Valley fever fungus)
KEGG Pathway
cim:CIMG_00232
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1EB31

Entry ID Method Resolution Chain Position Source
AF-Q1EB31-F1 Predicted AlphaFoldDB

No variants for Q1EB31

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1EB31

No associated diseases with Q1EB31

6 regional properties for Q1EB31

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 199 - 207 IPR000629
domain Helicase, C-terminal 279 - 438 IPR001650
domain DEAD/DEAH box helicase domain 72 - 241 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 67 - 270 IPR014001
domain RNA helicase, DEAD-box type, Q motif 48 - 76 IPR014014
domain Domain of unknown function DUF4217 429 - 492 IPR025313

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAPAHSRTGK PQKPFRQNNR SLKRKRNEDD LSSLTQRVGE LDPKSLAESF SELPLSDATL
70 80 90 100 110 120
QGLSASHFKT LTDIQSRAVP HAIKGRDILG AAKTGSGKTL AFLVPVLENL YRKQWTEYDG
130 140 150 160 170 180
LGALILSPTR ELAIQIFEVL RKIGRYHTFS AGLVIGGKSL QEEQERLGRM NILVCTPGRM
190 200 210 220 230 240
LQHMDQTAAF DTAHIQMLVL DEADRIMDMG FQSTVDAIVE HLPKERQTML FSATQTKKVS
250 260 270 280 290 300
DLARLSLRDP EYISVHEAAS SATPASLQQH YVVTPLPEKL DTLWSFIRNT LKSKILVFFS
310 320 330 340 350 360
SSKQVRFVYE AFRHMQPGIP LLHLHGRQKQ SARIDITSKF SRAKYSCLFS TDVAARGLDF
370 380 390 400 410 420
PAVDWVIQLD CPEDADTYIH RVGRTARYER DGRAVLFLDP SEEEGMLKRL EQKKIPIERI
430 440 450 460 470 480
NIKAKKQQSI MNQLQNMCFK DPALKYLGQK AFTSYVKSVH IQKDKDVFNV KSLPLEEFAS
490 500 510 520 530 540
SLGLPGAPRI KFIKGEDTKS RKNAPRHLAV VPSSDEDSDE EGLTKKKKEN EVRTKYDRMF
550 560 570 580 590 600
ERRNQDVLTE HYTKLIRDED EIDPDEKDNP AADADEDDGF LSVKRRFDAG DENLGEGLGS
610 620 630 640 650 660
EAEIDGIKKG KAVQIDGKEP LIIDSKRREK LLKSKKKLLK YKGKGTKLVY DDEGNAHEIY
670 680 690 700 710 720
EMEDEQQFKA QGDADAQRAK YLELEAERTR LADIRDKEIA KQKKREKKEK RRARARAERE
730 740 750 760 770 780
AEDGPVAVLA PYEEDEGLRE DDFSAEDRGS EDGRAPPSKK QKKWFQSDSD VDGEDGGKKR
790 800
KRPRAQSPAQ VETLEDLEAL AAELLE