Q1EAW8
Gene name |
SSN8 (CIMG_00295) |
Protein name |
RNA polymerase II holoenzyme cyclin-like subunit |
Names |
|
Species |
Coccidioides immitis (strain RS) (Valley fever fungus) |
KEGG Pathway |
cim:CIMG_00295 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q1EAW8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q1EAW8-F1 | Predicted | AlphaFoldDB |
No variants for Q1EAW8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q1EAW8 | |||||
No associated diseases with Q1EAW8
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mediator complex | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAADYWSSTQ | HQSWLFGREE | LAEARKVLGD | AERPFIQQYP | LPDLRLFNIY | VNQQLIKLAK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RLNVRQQALA | TAQVYVKRFY | TKVEIRRTNP | YLVLTTAFYL | ACKIEECPQH | IRLVLGEARG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LWPEFIAPDS | AKIGECEFWL | ISEMNSQLIV | HHPYRTLSEL | QSYLSLTSDE | IALAWSVIND |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HYLTDLLLLH | PPHVISVMAI | FIAVVFKPNQ | HQVVSISGGS | SATGALRDGS | TNILSAFNDK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TGAGMPAKVQ | RIVDWLANSD | INIEAVIECT | QDIVSLYEVW | EQYSEKVCKE | QIGRYVKSRG |
| LDK |