Q1E5T3

PR
Gene name
CHL1 (CIMG_02080)
Protein name
ATP-dependent DNA helicase CHL1
Names
Chromosome loss protein 1
Species
Coccidioides immitis (strain RS) (Valley fever fungus)
KEGG Pathway
cim:CIMG_02080
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

47-212 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1E5T3

Entry ID Method Resolution Chain Position Source
AF-Q1E5T3-F1 Predicted AlphaFoldDB

No variants for Q1E5T3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1E5T3

No associated diseases with Q1E5T3

4 regional properties for Q1E5T3

Type Name Position InterPro Accession
domain Helicase-like, DEXD box c2 type 6 - 420 IPR006554
domain ATP-dependent helicase, C-terminal 633 - 831 IPR006555
domain RAD3-like helicase, DEAD 199 - 398 IPR010614
domain Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type 4 - 428 IPR014013

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.

2 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
nucleobase-containing compound metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNPSSKTFYH PYSPYDIQVQ FMRSLYTCIE ECKVGIFESP TGTGKSLSLI CGSLTWLRDH
70 80 90 100 110 120
KRSVFLEDIE NSDGDDEPEW ILQYSRKEKR RIIRERRKRV EDRLSRIRKE ELLREKAAIA
130 140 150 160 170 180
NIPFKKQRLE DGKRHLDKMA DDGAFELDEY DSDNQETSTH DAKSNSDLSA TTIALLEKLS
190 200 210 220 230 240
GSAEIQDDFE EENAVKIFYC SRTHSQLAQF ARELRRVVFP PSIPPETEDG EIDTQGEGRR
250 260 270 280 290 300
HPDTELEEPT KHVSLGSRKT MCINPKVRRL GNATAINERC LDLQSSNVLP GHKCPFAPSK
310 320 330 340 350 360
ENELAINDFR DHVLAEVHDI EDIGKIGQRT GICPYYASRS VIGHSEIVTL PYQLLLQKSA
370 380 390 400 410 420
RDALDISLKD HVIIIDEAHN LMDVIANIHS VNVSLTQLRI GLEQLTIYAR KYKARLKGKN
430 440 450 460 470 480
RVYVAQVMRL LGSIAKYLES VLAARELREG AVDPSYLMSG KGIDQINLHK LSRYLQESKL
490 500 510 520 530 540
ARKVDGYIES STSLEEKNPE TSTTVPVLFQ VQSFLLSLMN PSAEGRLFFE KNGNDVLLKY
550 560 570 580 590 600
TLLDPTAHFR EAVEEARAVI LAGGTMSPMS DYRDHLFSYL APGQLRTFSY GHVIPTSNLS
610 620 630 640 650 660
ARPVSRGILD TEFDFTFEKR NSRAMIIDLG KTISEICKAT PDGVVAFFPS YDFLNQVVEI
670 680 690 700 710 720
WKQPCSNSGN PSILDSLGLV KPLLYESKEK AMNTEALLQK YANFIDEGKG ALLLSVMGGK
730 740 750 760 770 780
LSEGINFSDR LGRGVIVIGL PFANIRSAEW QAKIQYVERK TYERSSGGEE TRRSKAKLAG
790 800 810 820 830 840
RDFYENACMR VVNQCIGRAI RHQHDYAAIL MFDRRYGTAR IQSKLPEWIR RSLISAPIGA
850 860
TISNLYTFFE EKSSIEVTKE K