Q1D9V4

PR
Gene name
purL
Protein name
Phosphoribosylformylglycinamidine synthase
Names
FGAM synthase, FGAMS, Formylglycinamide ribonucleotide amidotransferase, FGAR amidotransferase, FGAR-AT
Species
Myxococcus xanthus (strain DK1622)
KEGG Pathway
mxa:MXAN_2349
EC number
6.3.5.3: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

429-499 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1D9V4

Entry ID Method Resolution Chain Position Source
AF-Q1D9V4-F1 Predicted AlphaFoldDB

No variants for Q1D9V4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1D9V4

No associated diseases with Q1D9V4

2 regional properties for Q1D9V4

Type Name Position InterPro Accession
domain ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type 121 - 292 IPR003135
domain ATP-grasp fold 117 - 306 IPR011761

Functions

Description
EC Number 6.3.5.3 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
phosphoribosylformylglycinamidine synthase activity Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate.

2 GO annotations of biological process

Name Definition
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MHTLRGAPAL SDFRLAKLLA QCRERVPSVS SIYAEFVHLI DAPAPLSEAD LATLGRLLDY
70 80 90 100 110 120
GPRVATGARI GSLLLVLPRP GTISPWSSKA TDIVHNCGLG ERVRRMERGT AFFIAGPDGQ
130 140 150 160 170 180
ALQDAELERL KPVLHDRMTQ AVVGRLEDAA ILFAGHTPRP FTTVDVLGGG RAALVTANRE
190 200 210 220 230 240
LGLALADDEM DYLVARFTEL KRNPTDVELM MFAQANSEHC RHKIFNASWT IDGKPQERSL
250 260 270 280 290 300
FQAIKNTYVQ HKEGVLGAYK DNAAVIEGFE VDRFFPSPES GEWGSVREPA HIMIKVETHN
310 320 330 340 350 360
HPTAISPYPG AATGAGGEIR DEGATGRGAR PKAGLTGFSV SHLRIPGFEQ PWEQPYGKPD
370 380 390 400 410 420
RIVSALDIMV DGPLGGAAFN NEFGRPNLTG YFRSYEVQVP TPGGVEVRGY HKPIMIAGGL
430 440 450 460 470 480
GNIRASHVQK GRLQPGDKLI VLGGPAMLIG LGGGAASSMA QGASAADLDF ASVQRDNAEM
490 500 510 520 530 540
ERRCQEVIDS CWALGDKNPI RSIHDVGAGG LSNAVPELAH DNDLGGRLEL RAVPNAEPGM
550 560 570 580 590 600
SPVEIWCNEA QERYVLGVAP EDLARFAALC ERERAPFSVL GDATAEQTLK LGDTQFGNAP
610 620 630 640 650 660
IDLPMDVLFG KPPRMHRDVT SRPVSFAPLT LDGSLALLAE RVLSHPTVAD KSFLITIGDR
670 680 690 700 710 720
TVSGLSSRDQ MVGPWQVPVA DCAVTLSTVT STTGEAMAMG ERTPLALIDA AASARMAVGE
730 740 750 760 770 780
ALTNIAAARI GKLSDVKLSA NWMAAAGSPG EDASLYAAVH AVGMELCPAL GLTIPVGKDS
790 800 810 820 830 840
MSMRTVWEEG GARKAVTSPV SLIISAFAPV LDVRKSLTPQ LVDVADDTRL LFIDLARGKQ
850 860 870 880 890 900
RLGGSVVAHV HGQVGPESPD VEDPALLRGF FAAVQALSES GSLLAYHDRS DGGLWATLCE
910 920 930 940 950 960
MAFAGRCGLD VDLAPLGGDV TAALFNEELG AVVQVRASDV ARVREVLAQH GLSRDVHELG
970 980 990 1000 1010 1020
RPVTALQVRV RHGGDTLMAE DTLALRRTWS RVSYEMQKLR DNPICADQES AARSDASDPG
1030 1040 1050 1060 1070 1080
LSPKLTFDPA QDVAAPFIAK GARPRVAVLR EQGVNSQQEM AAAFTRAGFA AVDVHMSDIL
1090 1100 1110 1120 1130 1140
SGRVSLEGFK GVLACGGFSY GDVLGAGGGW AKSILFNPRA RDAFAAFFAR PDSFGLGVCN
1150 1160 1170 1180 1190 1200
GCQMMSQLKD IIPGAEHFPR FVRNASEQYE ARLSLVEVSK TPSLFYQGME GSRMLIVTSH
1210 1220 1230 1240 1250 1260
GEGRAEFPSV EDAARVNGLG LVTTRWVDNH GRVAESYPAN PNGSPHGIAG LTTRDGRFTI
1270 1280 1290
TMPHPERVHR SVQHSWRPRE WGDDGPWMRM FRNARVWLG