Q1D084

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Myxococcus xanthus (strain DK1622)
KEGG Pathway
mxa:MXAN_5802
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

831-898 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1D084

Entry ID Method Resolution Chain Position Source
AF-Q1D084-F1 Predicted AlphaFoldDB

No variants for Q1D084

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1D084

No associated diseases with Q1D084

4 regional properties for Q1D084

Type Name Position InterPro Accession
domain DHHA1 domain 735 - 873 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 654 - 697 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 555 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 710 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPSALTASEI REAFLKFFEE RGHRRVASSS LVPANDPTLM FTNAGMVQFK DVFTGRETRD
70 80 90 100 110 120
YRRATTSQKC VRAGGKHNDL DNVGFTARHH TFFEMLGNFS FGDYFKADAI AYGWEFVTRT
130 140 150 160 170 180
LGLSTDRLAV TVFNGEGGTP WDEEAYELWK KQGVPAERLY KLGLKDNFWA MGDTGPCGPC
190 200 210 220 230 240
SEIHYHQGDD IPCVEEAEGK KCQGVACDCD RWLEIWNLVF MQFERKEKDG PLIPLPKPSI
250 260 270 280 290 300
DTGAGLERIA SVVQGKRSNY ETDLFQNILA TVSELCGKPY SQESGASQRV VADHSRAAAF
310 320 330 340 350 360
LISDGVQPSN EGRGYVLRRI MRRAIRHGTQ QLGLEDVFFF KVVDRVIELM GDAYPELRES
370 380 390 400 410 420
RTFVLEVCRH EETSFRQTLS RGLKLIEEEL SELQKAGGKQ LSGDVVFLLH GTYGFPWDLT
430 440 450 460 470 480
QIIARERGLD VDLVRFEERL KEEADKNKFA GSGDKATGEV YLKLAERLGT TEFLGYEGEG
490 500 510 520 530 540
HEGEGSIRAI VKDGAEVTQA TQGDTVELVL DRTPFYGESG GQMGDTGRIV GHGGKAVAKV
550 560 570 580 590 600
TDAQRPVPGL VVHSVEVSEG TFKVGDMVQA GVDSERRKSI RANHSATHLL HKALKLVLGE
610 620 630 640 650 660
HVKQAGSVVA PDYLRFDFAH FSPATSAQLE QVEDLVNGWI RDNAGAETRV MSLEDAKKSG
670 680 690 700 710 720
AVAMFGEKYG ETVRVVTVHP ESTELCGGTH VRRSGDIGLF KIASESGVAS GVRRIVALTG
730 740 750 760 770 780
IGALQHVREQ EHELRKVAEL LKSNPKEVSK RVEATQKRVK ELERKVEEVA VKAQTASSKD
790 800 810 820 830 840
LLEQARDVNG MKVLATQVDA ADDNVLRGMA DQLRDRIRSG VVAIGGEKDG RAIILVAATK
850 860 870 880 890
DVVAKGINAG ALVREMAKEV GGKGGGKAEM AQAGGPDASK LPAALEKLYE LVKGVGTA