Q1C373

PR
Gene name
glnE
Protein name
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
Names
ATP:glutamine synthetase adenylyltransferase, ATase
Species
Yersinia pestis bv Antiqua (strain Antiqua)
KEGG Pathway
ypa:YPA_3137
EC number
2.7.7.42: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1C373

Entry ID Method Resolution Chain Position Source
AF-Q1C373-F1 Predicted AlphaFoldDB

No variants for Q1C373

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1C373

No associated diseases with Q1C373

6 regional properties for Q1C373

Type Name Position InterPro Accession
domain ACT domain 693 - 777 IPR002912-1
domain ACT domain 800 - 876 IPR002912-2
domain Polymerase, nucleotidyl transferase domain 57 - 108 IPR002934
domain HD/PDEase domain 447 - 600 IPR003607
domain HD domain 451 - 584 IPR006674
domain PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase 176 - 314 IPR013546

Functions

Description
EC Number 2.7.7.42 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
[glutamate-ammonia-ligase] adenylyltransferase activity Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)].
[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase Catalysis of the reaction: adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] + H2O = AMP + [L-glutamate:ammonia ligase (ADP-forming)].
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.

2 GO annotations of biological process

Name Definition
metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
regulation of glutamine family amino acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLPLPSELQI QAQSIKQRFS ELPAPPDLRD EDIAVLALSD FVSDMLLIHP QWLEELHQQP
70 80 90 100 110 120
PQPQEWQYYS QWLSQALAGV QDEAALLTAL RLFRRRVMVR IAWSQVLQTS GTAETLQQLS
130 140 150 160 170 180
TLAESMIIAA RDWLYQVCCR ELGTPCNRQG VPQPLLILGM GKLGGGELNF SSDIDLIFAY
190 200 210 220 230 240
PENGQTQGGR RELDNAQFFT RLGQRLIKAL DQHTIDGFVY RVDMRLRPFG DSGPLVLSFA
250 260 270 280 290 300
ALEDYYQEQG RDWERYAMVK ARLMGGADDP YSQELRQMLR PFVFRRYIDF SVIQSLRNMK
310 320 330 340 350 360
GMIAREVRRR GLKDNIKLGA GGIREIEFIT QVFQLIRGGR EPRLQERALL PTLQAVAELG
370 380 390 400 410 420
LLPEQQVADL SGSYLFLRRL ENLLQAIADE QTQTLPNDPL NQARLAWGMG YADWAAMSTA
430 440 450 460 470 480
LENHMQAVRV VFDDLIGDET PDIGEDPSHG LYKSLWQDVL EESDLAPLTP HLEEAARRQL
490 500 510 520 530 540
LATISGFRHD VDKRTIGPRG REVLDQLMPR LFAEVCPRPD ANVALSRLIL LLLSIVTRTT
550 560 570 580 590 600
YLELLVEYHA ALKHVIRLCS ASPMVASQLA RYPLLLDELL DPQSLYQPLA PSAYRDELRQ
610 620 630 640 650 660
YLLRVPEDDE EQQLEALRQF KQAQQLRIAA GDITEALPVM KVSDHLTYLA EAIIDAVIQQ
670 680 690 700 710 720
AWNQMVARYG QPSHLQQSEG RGFAVIGYGK LGGWELGYSS DLDLVFLLDC PLDVMTDGDR
730 740 750 760 770 780
SIDGRQFYLR LAQRIMHLFS TRTSSGILYE VDARLRPSGE AGMLVSTIEA FADYQRNEAW
790 800 810 820 830 840
TWEHQALVRA RIVYGSPKLH QQFDAIRQQI LCRHREDPQL QQEVREMREK MRNHLGSKQR
850 860 870 880 890 900
DIFDIKADAG GITDIEFIAQ YLVLRYAASE PRLTRWSDNV RIFESMAHYD IMSPEEAAAL
910 920 930 940 950
TRAYVTMRDE IHHLALQEQS SKVAADSFIA EREQVAASWH KWLAANDANV S