Q1AWA6

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129 / PRD-1)
KEGG Pathway
rxy:Rxyl_1359
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

34-103 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1AWA6

Entry ID Method Resolution Chain Position Source
AF-Q1AWA6-F1 Predicted AlphaFoldDB

No variants for Q1AWA6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1AWA6

No associated diseases with Q1AWA6

4 regional properties for Q1AWA6

Type Name Position InterPro Accession
domain DHHA1 domain 736 - 872 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 653 - 696 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 554 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 709 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEHMKSAEIR RRFLDFFAER DHRIYPSSSL IPHDDPTVLL TTAGVQQFIP YFLGQEKPPH
70 80 90 100 110 120
PRAASVQKCF RTQDLEEVGD PSHLTFFEML GNFSFGDYFK KEAIGWAWEF LTEGLGIPPE
130 140 150 160 170 180
RLWVTIFEGD ENAPEDLEAK RFWMEVGVPE HKIFGLPKSE NWWGPAGETG PCGPCSEIYY
190 200 210 220 230 240
DYGEEFGPGD PLEDARYGPG GEEGDARFLE VWNLVFNQYE QLRDGSLRPL EQTGIDTGMG
250 260 270 280 290 300
LERIAAVMQG ARSVYETDLY APVIERAREY TGVALGDGEE TDRALRILAD HARGMAFLIA
310 320 330 340 350 360
DGVRPGNQRR EYVLRRIIRR ATREAYGRFG LDAGRIASLA ETVADYMGGF WGELREARDE
370 380 390 400 410 420
IRRVVESEAA RFIDIYHSGM RLLEAEISRL EGGRFPGEVA FTLHDTYGFP VEVTREVLAE
430 440 450 460 470 480
RGISLDEAGF RRAMERQRER AREALEGHER AVAAFRDREI RSRFVGYERE QAETRILAIE
490 500 510 520 530 540
PVPDAEGELY LVLEENPFYA TGGGQVADTG WISSEKGQLE VVDAIPAGDY QVLRARVERG
550 560 570 580 590 600
RFEAGDEVVA SINRVRRQQI EANHTATHIL HWALRAVLGK EVVQAGSYVG PDRLRFDYRY
610 620 630 640 650 660
SGRVTEEELA RVQELCLLKI TENQPVRYYT TTLEEARKLG AIMLFGEKYG ELVRVVEVDG
670 680 690 700 710 720
FSRELCGGTH VRGTAEIGAF KITSNRRHGA DLYRIEVITG REALYYLTRA AETAERLAAE
730 740 750 760 770 780
LRLPGVEELP EAVSRLREEL QQAREELRQQ ALKRGLEEVG SLVENAESID GTKVVTGRVA
790 800 810 820 830 840
AADVRDLRQI SDDVRNRVGG PVAVVLAADL DGKAVLVANF HPEVSKRVKA GDVVREAAGI
850 860 870 880
LGGGGGGSPT MAQAGGGNLE AIPAALERVR QILSRELSGR EA