Q19329
Gene name |
tag-151 (F10G7.1) |
Protein name |
Pre-rRNA-processing protein TSR1 homolog |
Names |
|
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F10G7.1 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q19329
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q19329-F1 | Predicted | AlphaFoldDB |
No variants for Q19329
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q19329 | |||||
1 associated diseases with Q19329
[MIM: 616346]: Developmental and epileptic encephalopathy 31 (DEE31)
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. {ECO:0000269|PubMed:25262651, ECO:0000269|PubMed:25533962, ECO:0000269|PubMed:27476654}. Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. {ECO:0000269|PubMed:25262651, ECO:0000269|PubMed:25533962, ECO:0000269|PubMed:27476654}. Note=The disease is caused by variants affecting the gene represented in this entry.
No regional properties for Q19329
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q19329 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| preribosome, small subunit precursor | A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| U3 snoRNA binding | Binding to a U3 small nucleolar RNA. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae. |
| maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTTGHRAGV | FKKPSKPHKS | WKGKRTKGEI | TSENRGREGV | KQLTRSAHST | HRTISKDARR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NQLKMARDQK | MADAMERRRT | SNAPCLVTVV | SLGVGARPTE | FIKKLATCDE | TIIQTTSPST |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IDFAIPRFKS | RVSFLTPDKD | NVDGVLDAIR | ASDVLCFLWP | MSAELSEWDE | QLLTIIKANG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LPTIVSVVPG | LGSIANHKKK | EDVRKGIEFI | ISKWSMSNAG | VMPADSVTDN | LQLLRILNET |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KKKPLTLQAR | HSYMLVENLE | CSDKTGETCT | LVAQGYLRGP | EWNANNLVHL | PGFGDFQISK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IESTVDPHPL | KAHNKTPEAQ | IIAKSDDKRQ | NTETEITPDS | MDGEQTWPTR | EELEEADKEL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RRVPKGTSSY | QAAWILDDED | DEDEEDSDED | MDDSDNEEVE | DDSEEEEPMD | DLKSEAGETT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ASEMMFDDGI | DEDINMAEVE | KYRKERENAQ | WPDEVDTPMD | MPARIAFQKY | RGLKSFRTST |
| 490 | 500 | 510 | 520 | 530 | 540 |
| WDPKENLPLD | YARIFQFANY | RNTKKNVMSK | IGGNDVDADS | VADKKFNGAF | ASVFIENVPV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AVLEAYKDAK | NLVLFQLLPH | EHKMSVLNMV | LKKHPSCTIP | ITSDQNQKFI | FYVGFRQFEA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NAVFSSNTPG | DKFKLERFMP | TEKTFVATVY | APITFNPATV | LCFRQDDKGR | QELVATGSIL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DSNPDRIVLK | RTVLAGHPYK | INRRAVVVRY | MFFNREDIEW | FKPVELYTPS | GRRGHIKEAV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GTHGNMKCRF | DQQLNAQDSV | MLNLYKRVFP | VWNYSIFNRS | LNPSRFVERS | RVESISLVNE |
| DAMEE |