Q18CS6
Gene name |
pyrD (CD630_01860) |
Protein name |
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit |
Names |
DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH) |
Species |
Clostridioides difficile (strain 630) (Peptoclostridium difficile) |
KEGG Pathway |
pdc:CDIF630_00307 |
EC number |
1.3.1.14: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q18CS6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q18CS6-F1 | Predicted | AlphaFoldDB |
No variants for Q18CS6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q18CS6 | |||||
No associated diseases with Q18CS6
1 regional properties for Q18CS6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Dihydroorotate dehydrogenase domain | 4 - 299 | IPR005720 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.3.1.14 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| dihydroorotate dehydrogenase activity | Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate. |
| orotate reductase (NADH) activity | Catalysis of the reaction: (S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| 'de novo' UMP biosynthetic process | The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGNLSVKFGS | VEFKNPVIMA | SGTFGFGKEY | NEIYDIQKLG | GISSKGLTLN | KKPGNNGMRV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HETSSGMMNS | VGLENPGVQG | FIDYELPFFS | KLDLVRIANV | GGGTLEDYLL | GVQMLNDKPI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DIIELNISCP | NVKAGGMAFG | IKNEVAREVV | REVRNITKLP | LVIKLSPNAE | DIVGMAKVCE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EEGADGVSLV | NTFKAMAIDI | KNRRPVFENV | YAGLSGPAIK | PIALRMVHEV | CKNVNIPVMG |
| 250 | 260 | 270 | 280 | 290 | |
| MGGITKATDA | IEFIMAGATC | IQVGTANFIN | PRIGIEIIDG | INEFMDREGI | KSLDEIRGII |