Q17QU3
Gene name |
ARPIN |
Protein name |
Arpin |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:613997 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q17QU3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q17QU3-F1 | Predicted | AlphaFoldDB |
59 variants for Q17QU3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs717449849 | 4 | I>V | No | EVA | |
| rs478932070 | 6 | Q>H | No | EVA | |
| rs469477643 | 38 | E>A | No | EVA | |
| rs450975800 | 49 | I>V | No | EVA | |
| rs435666334 | 50 | L>V | No | EVA | |
| rs468613696 | 52 | A>G | No | EVA | |
| rs479774658 | 54 | G>S | No | EVA | |
| rs482038391 | 55 | R>T | No | EVA | |
| rs445828459 | 55 | R>W | No | EVA | |
| rs463376484 | 56 | K>E | No | EVA | |
| rs432044268 | 61 | V>L | No | EVA | |
| rs464989098 | 62 | L>R | No | EVA | |
| rs449669350 | 63 | Y>S | No | EVA | |
| rs525974828 | 71 | R>C | No | EVA | |
| rs482538415 | 71 | R>P | No | EVA | |
| rs454316486 | 102 | V>G | No | EVA | |
| rs450178722 | 107 | D>A | No | EVA | |
| rs438103367 | 109 | D>G | No | EVA | |
| rs467796545 | 110 | R>I | No | EVA | |
| rs479092418 | 113 | P>R | No | EVA | |
| rs479080434 | 113 | P>S | No | EVA | |
| rs445185233 | 115 | A>G | No | EVA | |
| rs445185233 | 115 | A>V | No | EVA | |
| rs478084460 | 117 | K>R | No | EVA | |
| rs444166289 | 120 | V>E | No | EVA | |
| rs444166289 | 120 | V>G | No | EVA | |
| rs461775135 | 121 | N>K | No | EVA | |
| rs473929216 | 121 | N>Y | No | EVA | |
| rs440077256 | 124 | E>A | No | EVA | |
| rs440077256 | 124 | E>G | No | EVA | |
| rs472852828 | 126 | L>V | No | EVA | |
| rs451174782 | 127 | A>G | No | EVA | |
| rs471871994 | 129 | T>K | No | EVA | |
| rs432679404 | 129 | T>P | No | EVA | |
| rs456740006 | 130 | E>G | No | EVA | |
| rs438146897 | 133 | T>P | No | EVA | |
| rs208670623 | 137 | T>A | No | EVA | |
| rs434050574 | 142 | M>I | No | EVA | |
| rs449341291 | 142 | M>L | No | EVA | |
| rs211666055 | 147 | M>V | No | EVA | |
| rs445224021 | 152 | L>H | No | EVA | |
| rs462799278 | 158 | V>E | No | EVA | |
| rs450674074 | 162 | T>P | No | EVA | |
| rs458948299 | 166 | G>S | No | EVA | |
| rs481097034 | 181 | T>N | No | EVA | |
| rs459335271 | 183 | C>G | No | EVA | |
| rs447200444 | 183 | C>W | No | EVA | |
| rs480093220 | 186 | A>P | No | EVA | |
| rs458344444 | 188 | D>N | No | EVA | |
| rs439802962 | 189 | G>V | No | EVA | |
| rs475909530 | 197 | D>A | No | EVA | |
| rs463827285 | 198 | N>K | No | EVA | |
| rs442088701 | 200 | M>I | No | EVA | |
| rs475059557 | 203 | K>Q | No | EVA | |
| rs453171667 | 206 | E>K | No | EVA | |
| rs434663356 | 208 | A>P | No | EVA | |
| rs470678824 | 212 | T>P | No | EVA | |
| rs452197404 | 217 | D>G | No | EVA | |
| rs448211875 | 224 | W>R | No | EVA |
No associated diseases with Q17QU3
No regional properties for Q17QU3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q17QU3 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| lamellipodium | A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| directional locomotion | Self-propelled movement of a cell or organism from one location to another along an axis. |
| negative regulation of actin nucleation | Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. |
| negative regulation of cell migration | Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. |
| negative regulation of lamellipodium morphogenesis | Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium morphogenesis. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRIYQDSAL | RNKAVRSARL | PGAWDPAAHQ | RGDGVLLEGE | LLDVSRHSIL | DAHGRKERYY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VLYIRPSRIH | RRKFDPKGNE | IEPNFSATRK | VNTGFLMSSY | KVEAKGDSDR | LTPEALKGLV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NKPELLALTE | SLTPAETVAF | WMPESEMEAM | ELELGAGVRL | KTRGDGPFLD | SLAKLEAGTV |
| 190 | 200 | 210 | 220 | ||
| TKCNFAGDGK | TGASWTDNIM | AQKSSEGAAS | ETREQGDGAA | DEEWDD |