Q17QK6

PR
Gene name
FBXO2
Protein name
F-box only protein 2
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:512589
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q17QK6

Entry ID Method Resolution Chain Position Source
AF-Q17QK6-F1 Predicted AlphaFoldDB

188 variants for Q17QK6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs450539527 9 S>I No EVA
rs469072777 10 V>G No EVA
rs436154271 14 E>A No EVA
rs466654170 15 E>G No EVA
rs454582536 15 E>Q No EVA
rs433846983 16 A>G No EVA
rs452326443 17 S>T No EVA
rs470986769 21 Q>P No EVA
rs456584392 22 Q>* No EVA
rs475117344 22 Q>P No EVA
rs475117344 22 Q>R No EVA
rs442193731 24 E>K No EVA
rs460734981 25 A>V No EVA
rs439914963 28 E>A No EVA
rs479246423 28 E>K No EVA
rs458454639 29 E>G No EVA
rs477009061 30 A>G No EVA
rs450413536 34 E>A No EVA
rs469059317 34 E>D No EVA
rs450413536 34 E>G No EVA
rs720778501 34 E>Q No EVA
rs466591041 35 E>D No EVA
rs448134750 35 E>G No EVA
rs481176454 35 E>K No EVA
rs433781723 36 R>G No EVA
rs464441947 37 P>A No EVA
rs456470818 38 E>A No EVA
rs456470818 38 E>G No EVA
rs437952033 38 E>Q No EVA
rs435668436 39 D>E No EVA
rs475076308 39 D>G No EVA
rs454254892 40 D>A No EVA
rs472762521 40 D>E No EVA
rs454254892 40 D>G No EVA
rs439851734 42 E>G No EVA
rs458410472 43 G>A No EVA
rs476948491 44 E>A No EVA
rs476948491 44 E>G No EVA
rs462515722 45 A>E No EVA
rs462515722 45 A>G No EVA
rs443964957 45 A>P No EVA
rs460098684 46 A>E No EVA
rs460098684 46 A>G No EVA
rs448074611 46 A>P No EVA
rs437882949 47 Y>* No EVA
rs445817261 47 Y>D No EVA
rs464415294 47 Y>S No EVA
rs450007637 48 L>P No EVA
rs450007637 48 L>R No EVA
rs454191673 49 D>A No EVA
rs472700609 49 D>E No EVA
rs454191673 49 D>G No EVA
rs435606230 49 D>H No EVA
rs451807228 50 E>A No EVA
rs451807228 50 E>G No EVA
rs433314129 50 E>Q No EVA
rs451807228 50 E>V No EVA
rs443880160 51 L>P No EVA
rs443880160 51 L>Q No EVA
rs443880160 51 L>R No EVA
rs476882235 51 L>V No EVA
rs474382254 52 P>A No EVA
rs478516946 53 E>A No EVA
rs478516946 53 E>G No EVA
rs460037185 53 E>Q No EVA
rs445769001 54 P>A No EVA
rs482902884 55 L>P No EVA
rs457855416 55 L>V No EVA
rs435543112 56 L>P No EVA
rs468517207 56 L>V No EVA
rs447690127 57 L>P No EVA
rs466216609 58 R>P No EVA
rs451815963 59 V>G No EVA
rs455931265 60 L>P No EVA
rs455931265 60 L>Q No EVA
rs455931265 60 L>R No EVA
rs437416100 60 L>V No EVA
rs474318988 62 E>G No EVA
rs441521207 63 L>V No EVA
rs453580639 63 L>W No EVA
rs472042514 64 P>R No EVA
rs482858369 65 A>D No EVA
rs457870243 65 A>S No EVA
rs461997907 66 A>G No EVA
rs443426446 66 A>S No EVA
rs464619780 67 Q>H No EVA
rs480514371 68 L>Q No EVA
rs447626451 69 V>E No EVA
rs447626451 69 V>G No EVA
rs466151173 70 Q>* No EVA
rs470314383 72 C>F No EVA
rs445267244 72 C>R No EVA
rs437341014 75 V>G No EVA
rs455920483 76 C>R No EVA
rs467854693 76 C>W No EVA
rs435042435 77 L>P No EVA
rs471982498 78 R>P No EVA
rs439209048 79 W>C No EVA
rs451257352 80 K>E No EVA
rs476355045 80 K>R No EVA
rs443349412 81 E>G No EVA
rs441122337 85 G>D No EVA
rs478221406 86 A>G No EVA
rs799520309 86 A>T No EVA
rs478221406 86 A>V No EVA
rs445237721 91 L>P No EVA
rs470225172 92 K>E No EVA
rs482368978 93 C>* No EVA
rs467789201 99 V>L No EVA
rs447074511 100 P>T No EVA
rs465690436 102 D>A No EVA
rs432734322 103 G>C No EVA
rs476250501 107 E>Q No EVA
rs436874375 107 E>V No EVA
rs455458219 108 R>G No EVA
rs455458219 108 R>S No EVA
rs473966166 114 F>L No EVA
rs441061923 115 Y>F No EVA
rs459598617 116 F>C No EVA
rs471712657 117 L>P No EVA
rs463759781 120 R>W No EVA
rs449273695 123 N>D No EVA
rs449273695 123 N>H No EVA
rs461301666 123 N>K No EVA
rs479782563 124 L>P No EVA
rs465576680 125 L>P No EVA
rs451132785 126 R>G No EVA
rs469779100 126 R>L No EVA
rs436811518 127 N>K No EVA
rs455394737 128 P>A No EVA
rs453127208 129 C>* No EVA
rs434522000 129 C>R No EVA
rs453127208 129 C>W No EVA
rs471616882 130 G>W No EVA
rs463645222 131 E>* No EVA
rs468990632 142 H>D No EVA
rs436178387 142 H>R No EVA
rs466715691 146 G>V No EVA
rs433923366 149 V>G No EVA
rs452418785 150 E>G No EVA
rs466968967 151 E>D No EVA
rs471051684 169 Y>S No EVA
rs438073548 172 S>P No EVA
rs456658932 173 S>P No EVA
rs468553980 209 S>Y No EVA
rs480642721 210 G>S No EVA
rs466299446 213 D>A No EVA
rs433327025 219 E>G No EVA
rs451878990 231 V>L No EVA
rs470414130 234 E>* No EVA
rs437442098 235 F>V No EVA
rs455905539 241 A>E No EVA
rs474384440 242 V>G No EVA
rs717368772 252 T>I No EVA
rs449461344 254 I>S No EVA
rs467918170 255 S>F No EVA
rs453680489 256 H>N No EVA
rs472212860 256 H>P No EVA
rs432851477 256 H>Q No EVA
rs451319921 257 T>I No EVA
rs451319921 257 T>N No EVA
rs476376544 259 T>P No EVA
rs443458990 263 P>A No EVA
rs723689343 268 I>V No EVA
rs437584153 269 R>S No EVA
rs461998238 271 E>A No EVA
rs441132126 275 Q>R No EVA
rs459731364 277 C>* No EVA
rs478280801 278 V>G No EVA
rs445302942 279 Y>* No EVA
rs463706061 281 K>Q No EVA
rs482186046 282 G>D No EVA
rs449400087 283 W>S No EVA
rs467852379 284 F>L No EVA
rs465753943 288 V>E No EVA
rs465753943 288 V>G No EVA
rs432799638 289 T>A No EVA
rs451386231 290 N>S No EVA
rs476313073 291 S>C No EVA
rs436938024 292 S>R No EVA
rs455519740 293 V>G No EVA
rs474027258 294 W>G No EVA
rs441071080 295 V>A No EVA
rs441071080 295 V>G No EVA
rs438794826 296 E>D No EVA
rs471778250 296 E>G No EVA
rs453154868 296 E>K No EVA
rs463642313 298 P>R No EVA

No associated diseases with Q17QK6

2 regional properties for Q17QK6

Type Name Position InterPro Accession
domain F-box domain 45 - 92 IPR001810
domain F-box associated (FBA) domain 111 - 297 IPR007397

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Microsome membrane ; Peripheral membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
SCF ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

2 GO annotations of molecular function

Name Definition
amyloid-beta binding Binding to an amyloid-beta peptide/protein.
carbohydrate binding Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.

5 GO annotations of biological process

Name Definition
glycoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
regulation of protein ubiquitination Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein.
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
ubiquitin-dependent ERAD pathway The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UK22 FBXO2 F-box only protein 2 Homo sapiens (Human) PR
Q80UW2 Fbxo2 F-box only protein 2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MDGDGDPESV GQPEEASPEE QQEEACAEEA NGGEERPEDD GEGEAAYLDE LPEPLLLRVL
70 80 90 100 110 120
AELPAAQLVQ ACRLVCLRWK ELVDGAPLWL LKCQQEGLVP QDGPEDERDH WQQFYFLSKR
130 140 150 160 170 180
RRNLLRNPCG EEDLEGWCDV EHGGDGWRVE ELPGDCGVEF IHDESVKKYF ASSFEWCRKA
190 200 210 220 230 240
QIIDLQAEGY WEELLDTTQP AIVVKDWYSG RRDAGCLYEL TVKLLSEHED VLAEFNSGQV
250 260 270 280 290
AVPADSDDGG WTEISHTFTD YGPGVRFIRF EHGGQDCVYW KGWFGARVTN SSVWVEP