Q17QA0

PR
Gene name
GEMIN7
Protein name
Gem-associated protein 7
Names
Gemin-7
Species
Bos taurus (Bovine)
KEGG Pathway
bta:618024
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-78 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q17QA0

Entry ID Method Resolution Chain Position Source
AF-Q17QA0-F1 Predicted AlphaFoldDB

109 variants for Q17QA0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs473072000 2 Q>H No EVA
rs452978080 2 Q>K No EVA
rs441645697 3 T>P No EVA
rs475778346 4 P>R No EVA
rs444270763 7 T>P No EVA
rs457788867 10 P>L No EVA
rs477760842 11 V>L No EVA
rs440160561 13 R>L No EVA
rs479950884 16 R>G No EVA
rs448499834 16 R>L No EVA
rs479950884 16 R>W No EVA
rs468519830 17 G>D No EVA
rs468519830 17 G>V No EVA
rs482534190 18 P>A No EVA
rs464761880 19 D>E No EVA
rs451174171 19 D>V No EVA
rs433403342 20 G>R No EVA
rs466718635 22 N>I No EVA
rs455346382 24 G>V No EVA
rs475372916 25 F>I No EVA
rs444301666 25 F>L No EVA
rs451543240 26 A>P No EVA
rs451543240 26 A>S No EVA
rs479977187 28 D>A No EVA
rs442062011 28 D>E No EVA
rs460282652 28 D>N No EVA
rs479977187 28 D>V No EVA
rs482166453 30 R>G No EVA
rs447066942 31 R>S No EVA
rs478486070 31 R>T No EVA
rs467109455 32 A>P No EVA
rs455299943 35 K>Q No EVA
rs437598766 38 V>G No EVA
rs471539063 40 E>G No EVA
rs451184587 40 E>Q No EVA
rs453912129 45 R>P No EVA
rs473971717 46 E>* No EVA
rs442107797 46 E>G No EVA
rs473971717 46 E>Q No EVA
rs442107797 46 E>V No EVA
rs462270216 47 S>A No EVA
rs462270216 47 S>P No EVA
rs475888096 50 Q>P No EVA
rs444478470 51 Q>P No EVA
rs458108510 52 A>D No EVA
rs447066839 53 R>G No EVA
rs460763326 53 R>P No EVA
rs468939562 54 A>D No EVA
rs468939562 54 A>G No EVA
rs449456751 54 A>P No EVA
rs449456751 54 A>S No EVA
rs437632127 55 S>A No EVA
rs437632127 55 S>P No EVA
rs437632127 55 S>T No EVA
rs444818961 55 S>Y No EVA
rs431927907 56 L>P No EVA
rs453897385 57 R>L No EVA
rs453897385 57 R>P No EVA
rs474126123 58 E>A No EVA
rs436229341 58 E>D No EVA
rs474126123 58 E>G No EVA
rs474126123 58 E>V No EVA
rs456300805 59 R>G No EVA
rs475930774 59 R>P No EVA
rs440385951 60 Y>* No EVA
rs137074984 60 Y>C No EVA
rs458147391 60 Y>D No EVA
rs137074984 60 Y>F No EVA
rs458147391 60 Y>H No EVA
rs137074984 60 Y>S No EVA
rs460842800 61 L>I No EVA
rs480935836 61 L>P No EVA
rs449424765 62 R>L No EVA
rs449424765 62 R>P No EVA
rs462957222 63 S>G No EVA
rs462957222 63 S>R No EVA
rs482539238 63 S>R No EVA
rs444854746 64 L>P No EVA
rs433621566 65 L>P No EVA
rs447230514 66 A>G No EVA
rs436272629 67 M>K No EVA
rs467679908 67 M>L No EVA
rs467679908 67 M>V No EVA
rs456353581 68 V>E No EVA
rs456353581 68 V>G No EVA
rs469943019 69 G>R No EVA
rs438116007 70 R>G No EVA
rs451776159 70 R>H No EVA
rs471905087 71 P>A No EVA
rs454079421 72 V>G No EVA
rs474531399 73 C>G No EVA
rs443076518 77 H>Q No EVA
rs438961960 83 I>M No EVA
rs482977520 83 I>S No EVA
rs1118039125 85 H>R No EVA
rs458518732 91 L>R No EVA
rs467364475 95 N>K No EVA
rs447228240 95 N>T No EVA
rs481394750 111 A>P No EVA
rs469979815 112 L>P No EVA
rs432186408 114 R>G No EVA
rs452308861 115 C>G No EVA
rs465449896 119 I>F No EVA
rs434040386 120 S>P No EVA
rs454057597 121 Y>S No EVA
rs474183076 122 T>P No EVA
rs445696061 123 F>L No EVA
rs456717710 123 F>S No EVA
rs438998943 126 P>K No EVA

No associated diseases with Q17QA0

2 regional properties for Q17QA0

Type Name Position InterPro Accession
domain SUZ-C domain 1 - 29 IPR024642
domain Sm domain 59 - 125 IPR047575

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleoplasm
  • Nucleus, gem
  • Cytoplasm
  • Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies
  • Also found in the cytoplasm (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Gemini of coiled bodies Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA).
Sm-like protein family complex A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles.
SMN complex A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus.
SMN-Sm protein complex A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
spliceosomal snRNP assembly The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQTPLATPVP VLRLPRGPDG SNRGFAPDGR RAPPKPEVPE PPESRESWEQ QARASLRERY
70 80 90 100 110 120
LRSLLAMVGR PVCFTLHEGV QVIAHFGATD LDVANFYVSQ LQTPIGIQAE ALLRCSDIIS
YTFKP