Q17IE8

PR
Gene name
Cdk8 (AAEL002395)
Protein name
Cyclin-dependent kinase 8
Names
Cell division protein kinase 8, Mediator complex subunit Cdk8, Mediator of RNA polymerase II transcription subunit Cdk8
Species
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
KEGG Pathway
aag:5574480
EC number
2.7.11.23: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

343-501 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q17IE8

Entry ID Method Resolution Chain Position Source
AF-Q17IE8-F1 Predicted AlphaFoldDB

No variants for Q17IE8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q17IE8

No associated diseases with Q17IE8

3 regional properties for Q17IE8

Type Name Position InterPro Accession
domain Protein kinase domain 21 - 335 IPR000719
active_site Serine/threonine-protein kinase, active site 147 - 159 IPR008271
binding_site Protein kinase, ATP binding site 27 - 52 IPR017441

Functions

Description
EC Number 2.7.11.23 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

2 GO annotations of biological process

Name Definition
G1/S transition of mitotic cell cycle The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDYEFKMKTQ QERAKVEDLF EYEGCKVGRG TYGHVYKAHR KESNDTKDYA LKQIEGTGLS
70 80 90 100 110 120
MSACREIALL RELKHPNVIN LIRVFLSHTD RKVWLLFDYA EHDLWHIIKF HRAAKATKKP
130 140 150 160 170 180
VMVPKGMVKS LLYQILDGIH YLHSNWVLHR DLKPANILVM GEGNERGRVK IADMGFARLF
190 200 210 220 230 240
NAPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED
250 260 270 280 290 300
IKTSNPYHHD QLDRIFNVMG FPQDKDWEDI RKMPEHHTLT KDFKRSNYAN CSLVKYMERH
310 320 330 340 350 360
KIKPDSKAFH LLQKLLLMDP NKRITSEQAM QDPYFSEDPM PTADVFAGCP IPYPKREFLT
370 380 390 400 410 420
DEDQDDKGES KRQQQQQQQQ QANQQAQQNQ QQQANHQNQQ QNQQQQANQQ NQQSQQQQQQ
430 440 450 460 470 480
QQMQQQQQAQ AGGMDHSAAK RVRMSGPNGQ PGNGMNQQDY QVQQAQQAAA AAAAAQQQQQ
490 500
QQQQQQMMFN NQQQGGFQQR Y