Q17EN4
Gene name |
AAEL003729 |
Protein name |
Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial |
Names |
HOT |
Species |
Aedes aegypti (Yellowfever mosquito) (Culex aegypti) |
KEGG Pathway |
aag:5578877 |
EC number |
1.1.99.24: With other acceptors |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q17EN4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q17EN4-F1 | Predicted | AlphaFoldDB |
No variants for Q17EN4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q17EN4 | |||||
No associated diseases with Q17EN4
No regional properties for Q17EN4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q17EN4 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 1.1.99.24 | With other acceptors |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| alcohol dehydrogenase (NAD+) activity | Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. |
| hydroxyacid-oxoacid transhydrogenase activity | Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate. |
| metal ion binding | Binding to a metal ion. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| glutamate catabolic process via 2-oxoglutarate | The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxoglutarate. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMSKARISSL | MKVISSGSCS | CPAHSRSSTG | GLNVSSENEY | AFEMSSSTIR | YGPGVSKELG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HDLQNLNAKN | VCIVTDRNVA | KLNSVKVAFD | SLTRCGIQYQ | VYDETRVEPT | DQSLLHAAEY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ARQNKFDSFV | AIGGGSVIDT | CKVANLFSAD | REAEFLDYVN | APIGKAKEVN | VKLKPLIAVP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TTAGTGSETT | GVVIFDYKPL | HAKTGISSKY | LRPQLGLIDP | LHTLSQPEKV | AAYCGFDVFC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HALESFTAIP | YTERGSAPMN | PNLRPPYQGS | NPISDVWARF | ALKIIRENFI | SAVFNQDDLK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ARSNMHLAST | MAGVGFGNAG | VHLCHGLSYP | ISGHVKKFVP | DGYSGDHPII | PHGLSVVMTA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PAVFKFTAAS | CPERHLEAAE | LLGANVSKAN | RNDAGSILSD | VVRQYMYKLK | IENGLDSLGF |
| 430 | 440 | 450 | 460 | ||
| TRDDIQSLVK | GTLPQERITK | LAPRAQTEED | LASLFENSMT | VY |