Q17D30

PR
Gene name
AAEL004347
Protein name
Eukaryotic translation initiation factor 3 subunit M
Names
eIF3m
Species
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
KEGG Pathway
aag:5564581
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-71 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q17D30

Entry ID Method Resolution Chain Position Source
AF-Q17D30-F1 Predicted AlphaFoldDB

No variants for Q17D30

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q17D30

No associated diseases with Q17D30

2 regional properties for Q17D30

Type Name Position InterPro Accession
domain Proteasome component (PCI) domain 181 - 361 IPR000717
domain eIF3 subunit M, C-terminal helix domain 344 - 370 IPR040750

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
eukaryotic 43S preinitiation complex A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
eukaryotic 48S preinitiation complex A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.
eukaryotic translation initiation factor 3 complex, eIF3m An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m.

1 GO annotations of molecular function

Name Definition
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

1 GO annotations of biological process

Name Definition
formation of cytoplasmic translation initiation complex Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQGPAVFIDA EIDDQAQELR KFFKSLGAEI SEEKSSKGIE DDLHKIIGVC DVCFKDGTQH
70 80 90 100 110 120
TLEEIDAVLN SVVSIIVSIP LERGENLILA FCEKMTRAPD SNLARVCLQS LWRLFSNLEP
130 140 150 160 170 180
TSPLRYHVYY HLVQVAKRAD QVKEVFSGVD QLKSQFSQCP PSNEQMQKLY RLLHDVLKDT
190 200 210 220 230 240
NSELASKVMI ELLGTYTAEN ASYAREDAMK CIVTALADPN TFLLDPLLSL KPVRFLEGEL
250 260 270 280 290 300
IHDLLSVFVS EKLPSYLQFY KNHKEFVNSQ GLNHEQNIKK MRLLSFMQLA ESNPEMTFQQ
310 320 330 340 350 360
LQDELQIGEN EVEPFIIEVL KTKLVRARMD QKARKVHISS TMHRTFGRPQ WQQLRDLLHA
370 380
WKANLTLVQE NMKSVSEAQI ELAHKQ