Q17848
Gene name |
ipp-5 (C09B8.1) |
Protein name |
Probable type I inositol 1,4,5-trisphosphate 5-phosphatase |
Names |
5PTase |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_C09B8.1 |
EC number |
3.1.3.56: Phosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q17848
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q17848-F1 | Predicted | AlphaFoldDB |
No variants for Q17848
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q17848 | |||||
No associated diseases with Q17848
1 regional properties for Q17848
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Inositol polyphosphate-related phosphatase | 1 - 409 | IPR000300 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.3.56 | Phosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| inositol phosphate phosphatase activity | Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate. |
| inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity | Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. |
| inositol-1,4,5-trisphosphate 5-phosphatase activity | Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate. |
| inositol-polyphosphate 5-phosphatase activity | Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| epidermal growth factor receptor signaling pathway | The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| hermaphrodite genitalia morphogenesis | The process in which the anatomical structures of hermaphrodite genitalia are generated and organized. |
| inositol phosphate dephosphorylation | The process of removing a phosphate group from any mono- or polyphosphorylated inositol. |
| inositol phosphate-mediated signaling | A intracellular signal transduction in which the signal is transmitted within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6). |
| ovulation | The release of a mature ovum/oocyte from an ovary. |
| phosphatidylinositol dephosphorylation | The process of removing one or more phosphate groups from a phosphatidylinositol. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q14642 | INPP5A | Inositol polyphosphate-5-phosphatase A | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVQYLLITAN | VGSLFEPDAR | LHTSWIKTVA | DQVESVDPSF | FVIHLQETGG | KKFTECSQQV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PIIINRLSTA | LPKFDLLRAY | VDIDYEAIEY | TALGALCFIK | RSLWSNVSQF | NFHTKKYEQL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TSPKEVVTHG | LENYPYVVKH | KFPKDFWPSI | KWGRKGYMQT | RWKIENKVFD | FVNAHLFHDE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SNLALIHENP | QLYSQNRKRA | LDFVLAELSS | KENGCTPLLF | VFGDLNFRLD | SRSFLNRLTE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RTAQHPVADQ | EQMGSLADGL | QASAANLQVI | THPSENLRRT | VSAIEFRRES | DSDDSQNSCV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LRIEKKKFDY | FNHKKLLDDW | RSYRDDDKET | ENFQSMFEMH | INFPPTYPWS | EDPENSETLM |
| 370 | 380 | 390 | 400 | ||
| KTRAPAWCDR | VLMNKNAYSL | VEEGEPQYRS | FGMETCTGDH | KPVMLTFNI |