Q17635

PR
Gene name
ndc-80 (W01B6.9)
Protein name
Kinetochore protein ndc-80
Names
CeNDC-80, Hec1 homolog
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_W01B6.9
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-92 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q17635

Entry ID Method Resolution Chain Position Source
AF-Q17635-F1 Predicted AlphaFoldDB

No variants for Q17635

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q17635

No associated diseases with Q17635

1 regional properties for Q17635

Type Name Position InterPro Accession
domain Forkhead-associated (FHA) domain 22 - 93 IPR000253

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome, centromere, kinetochore
  • Cytoplasm, cytoskeleton
  • Localizes to kinetochores (PubMed:14522947)
  • The NDC80 complex localizes to microtubules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
Ndc80 complex An outer kinetochore protein complex that is part of the KMN kinetochore network (also known as the NMS complex) providing the platform with which the plus ends of spindle microtubules directly interact to form stable kinetochore-microtubule attachments. A common subunit nomenclature is used from yeast to human: Ndc80, Nuf2, Spc24, and Spc25.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
protein domain specific binding Binding to a specific domain of a protein.
protein-containing complex binding Binding to a macromolecular complex.

12 GO annotations of biological process

Name Definition
attachment of mitotic spindle microtubules to kinetochore The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex as part of mitotic metaphase plate congression.
attachment of spindle microtubules to kinetochore The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
gonad morphogenesis The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
mitotic chromosome movement towards spindle pole The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis.
positive regulation of kinetochore assembly Any process that activates or increases the frequency, rate or extent of kinetochore assembly.
positive regulation of mitotic sister chromatid separation Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation.
positive regulation of protein localization to kinetochore Any process that activates or increases the frequency, rate or extent of protein localization to kinetochore.
protein localization to kinetochore Any process in which a protein is transported to, or maintained at, the kinetochore.
protein localization to kinetochore involved in kinetochore assembly Any protein localization to kinetochore that is involved in kinetochore assembly.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFGDRRKTGG LNLNGRASIA ITPTKRFTDY TGSTSVRKTD ARPSLSQPRV SLFNTKNSSV
70 80 90 100 110 120
APRDVKSLVS LNGSKIYNFL VEYESSDAPS EQLIMKPRGK NDFIACFELI YQHLSKDYEF
130 140 150 160 170 180
PRHERIEEEV SQIFKGLGYP YPLKNSYYQP MGSSHGYPHL LDALSWLIDI IRINSAVSED
190 200 210 220 230 240
TQNILFGDFM EQGKAQEKTL NYAWMTSTFR DYTNDRKAAE NPSSSYWDDT KHRLRKYFEQ
250 260 270 280 290 300
SNEFEDMTKT AASALEMLNY ECDEIEADKG NEASLKEEIS RIRDDIRKAK DYLEQNLHVK
310 320 330 340 350 360
QHMEKELAMV KSEQEEKISE NEKVQKMVDD LKNKIELQKQ IHGLTGKEVR QMNLDNNKDK
370 380 390 400 410 420
EVVLEIQSEL DRLSKETWKL KDEDFFKEQK SKFIHLAEQI MKILSGLNIQ MNLEPLRAPT
430 440 450 460 470 480
NERDLKDYWE TLNKIWVPEI SRQLHQRKLE LETEQSRFSN KAVTAEERIQ IQSETLCEAK
490 500 510 520 530 540
KNEAREERIR RNERDSWKDA RKHIEQRYEQ LLNEKEVLLK QMKLDGSLEK EIEDETARMS
550 560 570 580
ATGEEHIQKR SQLEAGIRQI LDLMVVEIAE IENKKIGFHV QCAGIEKAVL