Q17361

PR
Gene name
usp-14 (tgt-1, C13B4.2)
Protein name
Ubiquitin carboxyl-terminal hydrolase 14
Names
Deubiquitinating enzyme 14, Ubiquitin thioesterase 14, Ubiquitin-specific-processing protease 14
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C13B4.2
EC number
3.4.19.12: Omega peptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

39-126 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q17361

Entry ID Method Resolution Chain Position Source
AF-Q17361-F1 Predicted AlphaFoldDB

No variants for Q17361

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q17361

No associated diseases with Q17361

5 regional properties for Q17361

Type Name Position InterPro Accession
domain Ubiquitin-like domain 2 - 71 IPR000626
domain Peptidase C19, ubiquitin carboxyl-terminal hydrolase 102 - 455 IPR001394
conserved_site Ubiquitin specific protease, conserved site 103 - 118 IPR018200-1
conserved_site Ubiquitin specific protease, conserved site 392 - 410 IPR018200-2
domain Ubiquitin specific protease domain 102 - 458 IPR028889

Functions

Description
EC Number 3.4.19.12 Omega peptidases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
proteasome complex A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.

2 GO annotations of molecular function

Name Definition
cysteine-type deubiquitinase activity An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
proteasome binding Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation.

3 GO annotations of biological process

Name Definition
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
protein deubiquitination The removal of one or more ubiquitin groups from a protein.
regulation of proteasomal protein catabolic process Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O14562 UBFD1 Ubiquitin domain-containing protein UBFD1 Homo sapiens (Human) PR
10 20 30 40 50 60
MPIVNVKWQK EKYVVEVDTS APPMVFKAQL FALTQVVPER QKVVIMGRTL GDDDWEGITI
70 80 90 100 110 120
KENMTIMMMG SVGEIPKPPT VLEKKQANRD KQAEEISALY PCGLANLGNT CYFNSCVQML
130 140 150 160 170 180
KEVNELVLKP AEEMRIREHN DRLCHNLATL FNSLRDKDRA LRSKGEPIKP FAAILTLSDS
190 200 210 220 230 240
FPQFEKFKQQ DANECLVSIM SNVTRIYGLS GWNIESLFRI QTETTMKCLE SDEVSEKKVE
250 260 270 280 290 300
RNNQLTCYVN QDVRFLQTGI KAGFEEEMTR NSEELNRDAK WQKNTQISRL PKYLTVNINR
310 320 330 340 350 360
FFYKESTKTN AKILKSVQFP MQLDTYDLCS QELKDKLVAR RADIKLEEDA KLERELRKKV
370 380 390 400 410 420
LDKEQGDKIF DDGVALPTAF EDDAGSNNSG FYDLKGIITH KGRSSQDGHY VAWMRSSEDG
430 440 450 460 470 480
KWRLFDDEHV TVVDEEAILK TSGGGDWHSA YVLLYEARVI KQFPELPPAP VPTEVAADTA
EPMEVSEKQ