Q16974

PR
Gene name
PRKC1
Protein name
Calcium-dependent protein kinase C
Names
APL I
Species
Aplysia californica (California sea hare)
KEGG Pathway
EC number
2.7.11.13: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

165-346 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

461-484 (Activation loop from InterPro)

Target domain

320-578 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q16974

Entry ID Method Resolution Chain Position Source
AF-Q16974-F1 Predicted AlphaFoldDB

No variants for Q16974

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q16974

No associated diseases with Q16974

12 regional properties for Q16974

Type Name Position InterPro Accession
domain C2 domain 138 - 261 IPR000008
domain Protein kinase domain 320 - 578 IPR000719
domain AGC-kinase, C-terminal 579 - 649 IPR000961
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 21 - 72 IPR002219-1
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 85 - 137 IPR002219-2
active_site Serine/threonine-protein kinase, active site 440 - 452 IPR008271
binding_site Protein kinase, ATP binding site 326 - 349 IPR017441
domain Protein kinase, C-terminal 599 - 640 IPR017892
domain Diacylglycerol/phorbol-ester binding 19 - 33 IPR020454-1
domain Diacylglycerol/phorbol-ester binding 35 - 44 IPR020454-2
domain Diacylglycerol/phorbol-ester binding 48 - 59 IPR020454-3
domain Diacylglycerol/phorbol-ester binding 124 - 136 IPR020454-4

Functions

Description
EC Number 2.7.11.13 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Translocated to neuronal membranes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium-dependent protein kinase C activity Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKRVARRGA LRQKNVHEVK NHKFLARFFK QPTFCSHCKD FIWGFGKQGF QCQVCSLVVH
70 80 90 100 110 120
KRCHEFVCFI CPGADKGPDS DATNLHKFKL HSYGSPTFCD HCGSLLYGLL HQGLKCDSCD
130 140 150 160 170 180
MNVHKRCEKN VPLLCGTDHT ERRGRILIKG AVKGSKVLVE ILEAKNLCPM DPNGLADPYV
190 200 210 220 230 240
KVKLIPYDAH KLKLKTKTIK ASLNPVWNES FTVDIGPEDN SKRLSLEVWD WDRTSRNDFM
250 260 270 280 290 300
GSLSFGISEL IKSPVEGWFK LLNQEEGEFY GVPVTDDITE SIQEIKSKMH RSSISSEKRY
310 320 330 340 350 360
PEPDKVQNMS KQDIVRASDF NFLTVLGKGS FGKVVLAERK GTDELYAIKI LKKDVIIQDD
370 380 390 400 410 420
DVECTMIEKR VLALPDKPPF LVQLHSCFQT MDRLYFVMEY VNGGDLMYRI QQEGKFKEPV
430 440 450 460 470 480
AAFYAAEIAI GLFYLHTQGI VYRDLKLDNV MLDAEGHIKI ADFGMCKENI MGDKTTRTFC
490 500 510 520 530 540
GTPDYIAPEI VLYQPYGRSV DWWAYGVLLY EMLAGQPPFD GEDEEELFTS ITDHNVSYPK
550 560 570 580 590 600
ALSREAVSLC KGLLTKTPAK RLGCGPNGER DIKDRAFFRP IQWERIELRE VQPPYKPRIK
610 620 630 640
SRKDVSNFDR EFTSEAPNVT PTDKLFIMNL DQCEFSGFSY VNPEFVVTV