AiPD: Autoinhibited Protein Database

Q16626

Gene name	MEA1 (MEA)
Protein name	Male-enhanced antigen 1
Names	MEA-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:4201
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

31-104 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

31-104 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q16626

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q16626-F1	Predicted				AlphaFoldDB

174 variants for Q16626

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA364149894 rs1314551818	2	G>E	Variant assessed as Somatic; 5.003e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA364149900 rs1268248193	2	G>R		No	ClinGen TOPMed
TCGA novel	3	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3812359 rs761068548	4	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1278971852 CA364149849	5	R>G		No	ClinGen TOPMed
CA364149832 rs199548045	5	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773447380 CA3812358	5	R>T		No	ClinGen ExAC gnomAD
rs1001039061 CA138215362	6	H>L		No	ClinGen Ensembl
rs890919796 CA138215358	7	L>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA364149771 rs1326838388	9	G>D		No	ClinGen gnomAD
rs968176354 CA138215352	10	A>T		No	ClinGen Ensembl
CA3812334 rs745407471	11	P>A		No	ClinGen ExAC TOPMed gnomAD
rs780843141 CA138215009	13	R>G		No	ClinGen ExAC TOPMed gnomAD
CA3812332 rs780843141	13	R>W		No	ClinGen ExAC TOPMed gnomAD
rs770761896 CA3812331	15	A>T		No	ClinGen ExAC gnomAD
rs1347445193 CA364148231	15	A>V		No	ClinGen TOPMed
rs777444697 CA3812329	17	V>A		No	ClinGen ExAC TOPMed gnomAD
CA364148201 rs1581869661	17	V>L		No	ClinGen Ensembl
rs1342886597 CA364148151	19	L>P		No	ClinGen gnomAD
rs758155183 CA3812328	20	G>E		No	ClinGen ExAC gnomAD
rs749948541	21	G>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1561856345 CA364148104	21	G>E		No	ClinGen Ensembl
CA364148041 rs1443586313	23	T>A		No	ClinGen TOPMed
rs752518644 CA3812326	23	T>N		No	ClinGen ExAC gnomAD
rs752518644 CA364148028	23	T>S		No	ClinGen ExAC gnomAD
CA3812325 rs778863183	24	M>V		No	ClinGen ExAC gnomAD
CA138214973 rs147653653	25	G>D		No	ClinGen ESP TOPMed
CA138214968 rs147653653	25	G>V		No	ClinGen ESP TOPMed
CA364147931 rs1262881695	27	E>K		No	ClinGen gnomAD
CA3812324 rs754905942	28	R>G		No	ClinGen ExAC gnomAD
rs766461819 CA3812322	28	R>H		No	ClinGen ExAC gnomAD
CA3812323 rs766461819	28	R>P		No	ClinGen ExAC gnomAD
CA364147856 rs1232152092	29	I>M		No	ClinGen TOPMed
rs201147988 CA138214957	29	I>N		No	ClinGen Ensembl
CA3812319 rs756150560	31	P>R		No	ClinGen ExAC gnomAD
CA364147796 rs1262361997	32	N>H		No	ClinGen gnomAD
CA3812318 rs750642194	32	N>S		No	ClinGen ExAC gnomAD
rs767728608 CA3812317	33	Q>*		No	ClinGen ExAC gnomAD
rs1309292808 CA364147747	33	Q>H		No	ClinGen TOPMed
CA3812316 rs762130343	33	Q>L		No	ClinGen ExAC gnomAD
rs35628750 CA3812314	35	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA567150188 rs1561856214	36	E>*		No	ClinGen Ensembl
rs764761304 CA364147693	36	E>*		No	ClinGen ExAC
CA3812313 rs764761304	36	E>K		No	ClinGen ExAC
rs763536971 CA3812312	40	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs2273916 CA3812310	42	P>S		No	ClinGen ExAC gnomAD
rs1335245340 CA364147462	43	S>*		No	ClinGen gnomAD
CA3812309 rs746483506	46	T>A		No	ClinGen ExAC gnomAD
rs139044997 CA3812308	46	T>N		No	ClinGen ESP ExAC gnomAD
rs747960499 CA3812306	49	W>*		No	ClinGen ExAC TOPMed
CA364147279 rs1463324025	49	W>S		No	ClinGen TOPMed
CA138214905 rs966948631	50	S>G		No	ClinGen TOPMed
CA364147174 rs1044202298	53	E>K		No	ClinGen TOPMed gnomAD
CA138214904 rs1044202298	53	E>Q		No	ClinGen TOPMed gnomAD
CA364147072 rs1241387910	56	E>V		No	ClinGen TOPMed gnomAD
rs950048903 CA138214893	57	E>D		No	ClinGen Ensembl
rs201793021 CA138214896	57	E>K		No	ClinGen 1000Genomes TOPMed gnomAD
TCGA novel	57	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364147019 rs778667067	58	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA3812305 rs778667067	58	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs754711875 CA3812304	60	E>K		No	ClinGen ExAC TOPMed gnomAD
CA364146922 rs1305615158	61	T>M		No	ClinGen gnomAD
rs1314349767 CA364146889	62	G>V		No	ClinGen gnomAD
CA364146854 rs1401799819	64	G>D		No	ClinGen TOPMed gnomAD
CA364146828 rs1312314614	65	P>L		No	ClinGen TOPMed gnomAD
CA364146785 rs1448416264	67	G>D		No	ClinGen TOPMed gnomAD
CA364146766 rs1581869172	68	Y>S		No	ClinGen Ensembl
CA364146717 rs1460727059	70	Y>*		No	ClinGen gnomAD
rs756169703 CA3812301	70	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs200945532 CA138214866	70	Y>H		No	ClinGen TOPMed gnomAD
CA364146726 rs756169703	70	Y>S		No	ClinGen ExAC TOPMed gnomAD
rs1223294528 CA364146687	72	P>T		No	ClinGen TOPMed
CA138214856 rs267601040	75	Q>*		No	ClinGen Ensembl
CA138214844 rs1028017104	77	P>L		No	ClinGen TOPMed
rs375848126 CA3812300	77	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs772384392 CA3812298	79	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA3812299 rs772384392	79	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs752025006 CA3812297	79	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA3812296 rs764564761	80	E>G		No	ClinGen ExAC gnomAD
CA364146490 rs1383656676	80	E>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs371497549 CA3812295	81	E>V		No	ClinGen ESP ExAC gnomAD
CA138214822 rs964442610	82	V>E		No	ClinGen Ensembl
rs776166108 CA3812294	85	A>T		No	ClinGen ExAC TOPMed gnomAD
CA3812293 rs765756373	85	A>V		No	ClinGen ExAC TOPMed gnomAD
CA138214798 rs985641164	86	P>A		No	ClinGen TOPMed
CA3812292 rs200343725	87	V>A		No	ClinGen ExAC TOPMed gnomAD
CA364146319 rs1293697601	88	G>R		No	ClinGen gnomAD
CA364146313 rs1293697601	88	G>W		No	ClinGen gnomAD
CA3812288 rs367986906	95	D>H		No	ClinGen ESP ExAC gnomAD
CA3812289 rs367986906	95	D>N		No	ClinGen ESP ExAC gnomAD
CA364146178 rs367986906	95	D>Y		No	ClinGen ESP ExAC gnomAD
CA138214775 rs1045936701	97	Q>*		No	ClinGen TOPMed
TCGA novel	97	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA138214770 rs878965517	99	R>G		No	ClinGen gnomAD
TCGA novel	99	R>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs374988758 CA138214764	99	R>Q		No	ClinGen ESP TOPMed gnomAD
CA3812287 rs768469726	100	I>T		No	ClinGen ExAC gnomAD
CA364146097 rs1355364964	101	Q>*		No	ClinGen TOPMed
CA364146099 rs1355364964	101	Q>E		No	ClinGen TOPMed
CA3812270 rs774014127	102	A>S		No	ClinGen ExAC TOPMed gnomAD
CA3812269 rs774014127	102	A>T		No	ClinGen ExAC TOPMed gnomAD
CA138214697 rs905955086	103	L>P		No	ClinGen TOPMed
rs368829003 CA3812268	104	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs762776779 CA3812266	106	H>N		No	ClinGen ExAC gnomAD
CA364145922 rs1266540406	109	D>A		No	ClinGen gnomAD
CA364145920 rs1266540406	109	D>G		No	ClinGen gnomAD
rs374235425 CA364145928	109	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs374235425 CA3812265	109	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs769673860 CA3812264	110	P>T		No	ClinGen ExAC TOPMed gnomAD
rs745827700 CA3812263	111	P>T		No	ClinGen ExAC gnomAD
CA364145869 rs1377418802	112	L>S		No	ClinGen TOPMed
CA364145859 rs1435435878	113	E>K		No	ClinGen TOPMed
CA3812260 rs1435435878	113	E>Q		No	ClinGen TOPMed
CA3812259 rs771067805	114	S>C		No	ClinGen ExAC gnomAD
rs1053062618 CA138214662	115	E>G		No	ClinGen Ensembl
rs747065879 CA3812258	116	D>N		No	ClinGen ExAC TOPMed gnomAD
CA364145798 rs747065879	116	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs1223450620 CA364145719	120	E>D		No	ClinGen TOPMed gnomAD
CA3812255 rs1554132459	120	E>G		No	ClinGen Ensembl
rs758693860 CA3812253	122	A>T		No	ClinGen ExAC gnomAD
rs1272058360 CA364145683	123	T>I		No	ClinGen TOPMed
CA3812252 rs148647027	124	A>V		No	ClinGen 1000Genomes ESP ExAC gnomAD
TCGA novel	125	L>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3812250 rs377500983	126	N>D		No	ClinGen ESP ExAC gnomAD
CA364145645 rs1406939980	127	N>H		No	ClinGen gnomAD
CA3812249 rs754402915	127	N>T		No	ClinGen ExAC TOPMed gnomAD
CA364145616 rs1169411277	129	S>G		No	ClinGen gnomAD
rs1372138346 CA364145588	131	I>F		No	ClinGen TOPMed gnomAD
CA3812245 CA364145560 rs751038228	133	M>I		No	ClinGen ExAC TOPMed gnomAD
rs761360850 CA3812247	133	M>L		No	ClinGen ExAC gnomAD
rs763799267 CA3812244	134	D>N		No	ClinGen ExAC TOPMed gnomAD
rs943136542 CA138214622	134	D>V		No	ClinGen Ensembl
rs1267023605 CA364145538	136	E>K		No	ClinGen gnomAD
rs377322516 CA3812225	137	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA364145462 rs1291394718	137	H>R		No	ClinGen gnomAD
rs764777839 CA3812223	138	V>G		No	ClinGen ExAC gnomAD
CA138214476 rs373282030	140	L>V		No	ClinGen ESP
CA364145419 rs1281152226	141	V>L		No	ClinGen TOPMed gnomAD
CA364145420 rs1281152226	141	V>M		No	ClinGen TOPMed gnomAD
CA138214471 rs943021939	145	M>I		No	ClinGen Ensembl
rs1274093489 CA364145336	147	G>E		No	ClinGen TOPMed
rs975747144 CA138214468	148	V>L		No	ClinGen TOPMed gnomAD
rs962380755 TCGA novel CA138214465	149	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen TOPMed
rs142191404 CA3812221	152	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs951168197 CA138214464	153	P>T		No	ClinGen TOPMed
CA3812219 rs760702310	154	G>R		No	ClinGen ExAC
CA364145259 rs1178240639	155	V>I		No	ClinGen gnomAD
TCGA novel	155	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1470049244 CA364145237	157	A>T		No	ClinGen gnomAD
rs1231726222 CA364145198	159	A>V		No	ClinGen TOPMed gnomAD
rs183141686 CA3812218	160	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs748130085 CA3812216	160	R>Q		No	ClinGen ExAC gnomAD
rs183141686 CA3812217	160	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs774682451 CA3812215 COSM168033	163	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA364145129 rs1318756719	165	A>G		No	ClinGen gnomAD
rs1223329962 CA364145107	167	W>*		No	ClinGen gnomAD
CA3812212 rs780378952	168	E>G		No	ClinGen ExAC gnomAD
CA3812213 rs749727967	168	E>K		No	ClinGen ExAC gnomAD
CA364145083 rs1406536882	169	D>N		No	ClinGen gnomAD
CA3812211 rs756409268	170	V>M		No	ClinGen ExAC gnomAD
CA364145043 rs1433889034	172	Q>*		No	ClinGen gnomAD
CA3812210 rs746375731	172	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs757954289 CA3812208	175	L>V		No	ClinGen ExAC gnomAD
rs1356684293 CA364144994	176	Q>*		No	ClinGen TOPMed
rs754577473 CA3812205	178	R>L		No	ClinGen ExAC TOPMed gnomAD
rs754577473 CA364144968	178	R>P		No	ClinGen ExAC TOPMed gnomAD
rs754577473 CA364144970	178	R>Q	Variant assessed as Somatic; 4.668e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs765010140 CA3812207	178	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1328418409 CA364144957	179	Q>R		No	ClinGen TOPMed
rs1429050529 CA364144947	180	A>T		No	ClinGen TOPMed gnomAD
rs753473018 CA3812204	181	S>A		No	ClinGen ExAC gnomAD
rs766285051 CA3812203	181	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs11751058 VAR_058297 CA3812201	183	A>D		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA138214407 rs377566821	185	K>N		No	ClinGen Ensembl

No associated diseases with Q16626

No regional properties for Q16626

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q16626

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
male gonad development	The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q95313	MEA1	Male-enhanced antigen 1	Sus scrofa (Pig)	PR

10	20	30	40	50	60
MGPERHLSGA	PARMATVVLG	GDTMGPERIF	PNQTEELGHQ	GPSEGTGDWS	SEEPEEEQEE
70	80	90	100	110	120
TGSGPAGYSY	QPLNQDPEQE	EVELAPVGDG	DVVADIQDRI	QALGLHLPDP	PLESEDEDEE
130	140	150	160	170	180
GATALNNHSS	IPMDPEHVEL	VKRTMAGVSL	PAPGVPAWAR	EISDAQWEDV	VQKALQARQA

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