AiPD: Autoinhibited Protein Database

Q16342

Gene name	PDCD2 (RP8, ZMYND7)
Protein name	Programmed cell death protein 2
Names	Zinc finger MYND domain-containing protein 7, Zinc finger protein Rp-8
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5134
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

81-265 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

81-265 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q16342

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q16342-F1	Predicted				AlphaFoldDB

321 variants for Q16342

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1307165418 CA366525004	3	A>S		No	ClinGen TOPMed
CA366525001 rs1320743862	3	A>V		No	ClinGen TOPMed
rs896978485 CA152244560	4	A>T		No	ClinGen TOPMed gnomAD
CA366524992 rs1485423285	5	G>A		No	ClinGen TOPMed gnomAD
CA366524995 CA152244556 rs1041184596	5	G>R		No	ClinGen TOPMed
rs1485423285 CA366524991	5	G>V		No	ClinGen TOPMed gnomAD
CA366524994 rs1041184596	5	G>W		No	ClinGen TOPMed
rs1050200789 CA366524988	6	A>D		No	ClinGen gnomAD
CA152244531 rs567261750	6	A>T		No	ClinGen 1000Genomes TOPMed gnomAD
CA152244519 rs1050200789	6	A>V		No	ClinGen gnomAD
CA366524986 rs1226551155	7	R>G		No	ClinGen gnomAD
rs1338569072 CA366524982	7	R>K		No	ClinGen gnomAD
rs1280145723 CA366524980	7	R>S		No	ClinGen TOPMed gnomAD
CA152244513 rs1030294600	9	V>G		No	ClinGen TOPMed
CA366524973 rs1345115305	9	V>M		No	ClinGen TOPMed gnomAD
rs1407451272 CA366524959	11	L>V		No	ClinGen gnomAD
rs548662103 CA4108871	13	F>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA152244503 rs548662103	13	F>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs559964311 CA152244498	16	S>P		No	ClinGen 1000Genomes TOPMed gnomAD
CA152244494 rs966876881	18	P>L		No	ClinGen TOPMed gnomAD
CA366524894 rs1329800914	21	R>L		No	ClinGen TOPMed gnomAD
rs1329800914 CA366524896	21	R>Q		No	ClinGen TOPMed gnomAD
rs1172183055 CA366524888	23	R>S		No	ClinGen gnomAD
rs1298385056 CA366524881	24	S>G		No	ClinGen gnomAD
CA366524879 rs1383090409	24	S>T		No	ClinGen TOPMed gnomAD
rs1477821867 CA366524872	25	E>*		No	ClinGen gnomAD
CA152244485 rs886642134	25	E>G		No	ClinGen TOPMed
CA366524873 rs1477821867	25	E>Q		No	ClinGen gnomAD
rs1245781109 CA366524865	26	Q>*		No	ClinGen gnomAD
CA366524858 rs1384725059	27	F>L		No	ClinGen gnomAD
rs1583146611 CA366524847	28	P>L		No	ClinGen Ensembl
rs773036976 CA152244479	28	P>S		No	ClinGen TOPMed gnomAD
rs545103128 CA152244472	29	S>R		No	ClinGen 1000Genomes TOPMed gnomAD
rs1485404994 CA366524833	30	K>N		No	ClinGen TOPMed
rs1315976333 CA366524817	33	G>W		No	ClinGen gnomAD
rs1001626835 CA366524810	34	R>L		No	ClinGen TOPMed
rs1001626835 CA152244471	34	R>P		No	ClinGen TOPMed
CA366524812 rs1260153564	34	R>W		No	ClinGen TOPMed gnomAD
CA366524792 rs1412114104	37	W>*		No	ClinGen TOPMed
CA152244465 rs907429950	38	L>Q		No	ClinGen TOPMed
rs769150716 CA4108869	40	A>V		No	ClinGen ExAC gnomAD
CA4108868 rs749670057	42	G>R		No	ClinGen ExAC TOPMed gnomAD
rs947729536 CA152244438	43	L>P		No	ClinGen TOPMed
rs916232780 CA152244432	44	P>A		No	ClinGen TOPMed
CA4108866 rs755759947	45	G>R		No	ClinGen ExAC
CA366524743 rs1583146478	46	P>L		No	ClinGen Ensembl
CA366524740 rs1445298245	47	Q>*		No	ClinGen TOPMed gnomAD
rs1403087872 CA366524729	48	A>V		No	ClinGen TOPMed gnomAD
CA366524727 rs1260727509	49	L>V		No	ClinGen TOPMed gnomAD
CA4108860 rs763817884	51	C>*		No	ClinGen ExAC gnomAD
rs757144594 CA4108863	51	C>S		No	ClinGen ExAC gnomAD
rs763817884 CA4108861	51	C>W		No	ClinGen ExAC gnomAD
CA4108862 rs757144594	51	C>Y		No	ClinGen ExAC gnomAD
rs762795976 CA366524691	55	G>C		No	ClinGen ExAC TOPMed gnomAD
rs762795976 CA4108859	55	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs61756020 CA4108857	57	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	59	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366524643 rs562369624	62	L>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1221204520 CA366524623	63	Q>P		No	ClinGen TOPMed gnomAD
rs1221204520 CA366524622	63	Q>R		No	ClinGen TOPMed gnomAD
CA366524609 rs1279113436	64	V>G		No	ClinGen gnomAD
CA152244337 rs1040903779	64	V>L		No	ClinGen gnomAD
CA152244330 rs954647065	66	A>T		No	ClinGen TOPMed
CA366524568 rs1238443523	66	A>V		No	ClinGen gnomAD
CA4108852 rs774982075	67	P>L		No	ClinGen ExAC TOPMed gnomAD
rs774982075 CA366524554	67	P>R		No	ClinGen ExAC TOPMed gnomAD
CA366524530 rs74482927	69	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV000965744 CA4108850 rs74482927	69	P>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs889888884 CA152244286	69	P>S		No	ClinGen TOPMed
CA4108848 rs769437764	70	G>S		No	ClinGen ExAC gnomAD
CA4108847 rs745536645	71	R>L		No	ClinGen ExAC TOPMed gnomAD
CA366524482 rs1179227419	72	P>L		No	ClinGen gnomAD
rs1235865501 CA366524471	73	D>N		No	ClinGen gnomAD
CA366524449 rs1285600261	74	A>G		No	ClinGen gnomAD
rs756772582 CA4108845	74	A>S		No	ClinGen ExAC TOPMed gnomAD
rs756772582 CA366524456	74	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1216934637 CA366524439	75	F>S		No	ClinGen TOPMed
rs1252833014 CA366524427	76	H>Y		No	ClinGen TOPMed
rs751128316 CA4108844	78	C>S		No	ClinGen ExAC gnomAD
CA4108843 rs777682956	78	C>Y		No	ClinGen ExAC gnomAD
rs1245961743 CA366524368	79	I>S		No	ClinGen TOPMed gnomAD
CA4108842 rs555642254	79	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1286403781 CA366524304	82	F>S		No	ClinGen gnomAD
CA366524235 rs1417451255	85	R>H		No	ClinGen gnomAD
rs750683402 CA4108838	87	Q>E		No	ClinGen ExAC gnomAD
rs11557807 CA152244188	87	Q>H		No	ClinGen Ensembl
rs117413937 CA4108836	88	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs117413937 CA366524144	88	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200184000 CA4108837	88	P>S		No	ClinGen ExAC TOPMed gnomAD
CA366524158 rs200184000	88	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1311899321 CA366524096	90	C>Y		No	ClinGen gnomAD
CA4108834 rs764637050	92	G>S		No	ClinGen ExAC TOPMed gnomAD
rs763390393 CA4108833	94	R>Q		No	ClinGen ExAC gnomAD
rs148653243 CA4108800	95	V>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA366523634 rs749064967	96	F>L		No	ClinGen ExAC gnomAD
rs749064967 CA4108799	96	F>V		No	ClinGen ExAC gnomAD
rs146332925 CA4108798	97	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs751833442 CA4108796	99	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA366523524 rs1397364784	101	P>R		No	ClinGen gnomAD
CA366523542 rs1448863958	101	P>S		No	ClinGen gnomAD
rs1302325047 CA366523522	102	R>G		No	ClinGen gnomAD
CA4108794 rs758393282	103	K>R		No	ClinGen ExAC TOPMed gnomAD
CA152243349 rs921145029	104	N>K		No	ClinGen TOPMed gnomAD
CA152243327 rs901575261	105	D>A		No	ClinGen TOPMed
CA4108792 rs367868951	105	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs367868951 CA4108793	105	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA152243321 rs1038856281	108	S>*		No	ClinGen TOPMed gnomAD
rs1305779691 CA366523378	109	Y>H		No	ClinGen TOPMed
TCGA novel	111	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA152243310 rs867256439	111	P>T		No	ClinGen Ensembl
CA4108790 rs535353957	112	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs535353957 CA4108789	112	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1239540021 CA366523319	113	S>P		No	ClinGen TOPMed
CA366523271 rs1440831997	115	N>S		No	ClinGen gnomAD
CA4108787 rs772756754	116	P>L		No	ClinGen ExAC gnomAD
rs76108444 CA152243275	116	P>T		No	ClinGen 1000Genomes gnomAD
rs1481955116 CA366523243	117	P>S		No	ClinGen TOPMed gnomAD
CA152243271 rs551395095	118	P>A		No	ClinGen 1000Genomes
CA366523223 rs1562370505	118	P>Q		No	ClinGen Ensembl
CA366523158 rs1352769463	122	E>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1049488537 CA152243224	123	S>P		No	ClinGen TOPMed
rs768662184 CA4108783	124	V>A		No	ClinGen ExAC gnomAD
rs929231855 CA366523122	124	V>L		No	ClinGen TOPMed gnomAD
rs929231855 CA152243208	124	V>M		No	ClinGen TOPMed gnomAD
CA4108782 rs749267353	125	C>F		No	ClinGen ExAC gnomAD
rs1583144836 CA366523072	126	L>F		No	ClinGen Ensembl
CA366523015 rs1432424578	130	S>A		No	ClinGen TOPMed
TCGA novel	130	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779926843 CA4108781	131	G>V		No	ClinGen ExAC gnomAD
TCGA novel	132	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1313755379 CA366522966	133	H>R		No	ClinGen TOPMed gnomAD
CA4108780 rs769722657	135	C>Y		No	ClinGen ExAC gnomAD
rs568563523 CA4108779	136	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1268256320 CA366522914	136	R>S		No	ClinGen TOPMed
CA366522887 rs1420620795	138	C>S		No	ClinGen gnomAD
TCGA novel	139	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1445425021 CA366522855	140	C>R		No	ClinGen gnomAD
CA4108775 rs752697924	140	C>W		No	ClinGen ExAC gnomAD
CA4108774 rs779072921 CA366522829	141	L>*		No	ClinGen ExAC TOPMed gnomAD
CA4108772 rs754349565	141	L>F		No	ClinGen ExAC
CA366522827 rs779072921	141	L>S		No	ClinGen ExAC TOPMed gnomAD
rs766675033 CA4108771	142	G>S		No	ClinGen ExAC TOPMed gnomAD
CA366522790 rs1188277838	142	G>V		No	ClinGen TOPMed gnomAD
rs767050564 CA4108769	143	P>L		No	ClinGen ExAC TOPMed gnomAD
rs767050564 CA4108768	143	P>R		No	ClinGen ExAC TOPMed gnomAD
rs761545534 CA4108767	144	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA366522769 COSM1219910 rs1562370339	144	K>R	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1215519732 CA366522743	145	T>M		No	ClinGen TOPMed
CA4108766 rs372293466	146	C>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA366522695 rs372293466	146	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA4108763 rs149555889	147	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs762924182 CA4108764	147	S>P		No	ClinGen ExAC gnomAD
TCGA novel	148	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366522663 rs1393911522	148	R>K		No	ClinGen TOPMed
rs1399700138 CA366522583	151	K>E		No	ClinGen gnomAD
rs1338717671 CA366522581	151	K>T		No	ClinGen gnomAD
rs1416865111 CA366522553	152	A>G		No	ClinGen TOPMed gnomAD
rs368569104 CA4108761	152	A>P		No	ClinGen ESP ExAC gnomAD
CA4108760 rs368569104	152	A>T		No	ClinGen ESP ExAC gnomAD
rs1416865111 CA366522550	152	A>V		No	ClinGen TOPMed gnomAD
rs748435640 CA4108758	153	Y>C		No	ClinGen ExAC gnomAD
rs1459879826 CA366522461	156	S>G		No	ClinGen gnomAD
rs1419466134 CA366522445	157	K>E		No	ClinGen TOPMed gnomAD
rs1315925712 CA366522394	158	E>D		No	ClinGen TOPMed
rs1390590960 CA366522370	159	H>N		No	ClinGen TOPMed
CA366522366 rs1435676056	159	H>R		No	ClinGen TOPMed
rs778899901 CA4108757	160	Q>H		No	ClinGen ExAC gnomAD
rs375620318 CA366522319	161	T>I		No	ClinGen ESP gnomAD
rs375620318 CA152243067	161	T>N		No	ClinGen ESP gnomAD
rs1447401472 CA366522274	163	D>E		No	ClinGen gnomAD
CA4108755 rs753980808	164	W>*		No	ClinGen ExAC
rs1583144521 CA366522249	164	W>*		No	ClinGen Ensembl
CA152243058 rs780538358	165	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4108754 rs780538358	165	R>T		No	ClinGen ExAC TOPMed gnomAD
rs756658704 CA4108753	168	H>R		No	ClinGen ExAC gnomAD
rs750701272 CA4108752	169	K>E		No	ClinGen ExAC TOPMed gnomAD
CA4108750 rs756790601	171	A>P		No	ClinGen ExAC TOPMed gnomAD
CA366522176 rs1280368921	172	C>S		No	ClinGen gnomAD
CA366522171 rs1228389140	173	A>T		No	ClinGen gnomAD
CA4108749 rs772263336	173	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1395423021 CA366521982	177	H>Y		No	ClinGen gnomAD
CA366521963 rs1437734028	179	D>E		No	ClinGen gnomAD
TCGA novel	179	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366521960 rs1234744113	180	H>Y		No	ClinGen TOPMed gnomAD
TCGA novel	184	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366521932 rs1276804074	184	D>N		No	ClinGen gnomAD
rs776651392 CA4108722	186	N>D		No	ClinGen ExAC gnomAD
CA4108721 rs766274052	186	N>S		No	ClinGen ExAC gnomAD
rs778255010 CA152242624	187	F>S		No	ClinGen Ensembl
CA366521904 rs773053732	188	L>F		No	ClinGen ExAC TOPMed gnomAD
rs773053732 CA4108719	188	L>I		No	ClinGen ExAC TOPMed gnomAD
CA4108718 rs375838507	189	F>L		No	ClinGen ESP ExAC gnomAD
rs932358258 CA152242577	190	P>L		No	ClinGen Ensembl
CA4108716 rs577424007	190	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	191	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs558824933 CA4108714	194	I>M		No	ClinGen 1000Genomes ExAC gnomAD
rs373202680 CA4108713	195	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	197	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA152242543 rs781338071	198	T>A		No	ClinGen Ensembl
rs757772974 CA4108712	200	D>N		No	ClinGen ExAC gnomAD
CA4108710 rs778296317 CA4108709	201	E>D		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	203	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4108707 rs758056878	204	P>S		No	ClinGen ExAC gnomAD
CA366521786 rs1471933080	205	E>D		No	ClinGen Ensembl
rs752427699 CA4108706	206	V>A		No	ClinGen ExAC TOPMed gnomAD
rs754486906 CA4108704	207	V>M		No	ClinGen ExAC gnomAD
CA366521740 rs1214921989	212	Y>D		No	ClinGen gnomAD
rs899489150 CA152242508	214	E>G		No	ClinGen Ensembl
CA4108702 rs753325570	214	E>K		No	ClinGen ExAC gnomAD
rs760583517 CA4108700	218	S>G		No	ClinGen ExAC TOPMed gnomAD
CA4108699 CA152242484 rs192662962	218	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4108698 rs767335031	219	M>V		No	ClinGen ExAC gnomAD
rs1312340714 CA366521368	220	G>A		No	ClinGen TOPMed
CA152242478 rs946628632	220	G>S		No	ClinGen gnomAD
CA152240150 rs949889673	221	E>*		No	ClinGen Ensembl
rs917342588 CA152240148	221	E>A		No	ClinGen Ensembl
rs1413154881 CA366521355	222	A>V		No	ClinGen gnomAD
CA4108668 rs779199451	223	L>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	224	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1439612570 CA366521331	226	E>*		No	ClinGen TOPMed gnomAD
rs138337157 CA4108665	226	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1479429105 CA366521324	227	L>P		No	ClinGen TOPMed
CA4108664 rs150472476	227	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA4108662 rs745426165	230	M>T		No	ClinGen ExAC gnomAD
rs376751655 CA4108663	230	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs141160861 CA4108661	232	K>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA366521284 rs1345526917	233	H>R		No	ClinGen TOPMed gnomAD
CA4108660 rs757244867	234	E>A		No	ClinGen ExAC gnomAD
rs56926064 CA4108659	235	S>F		No	ClinGen ExAC gnomAD
rs56926064 CA152240116	235	S>Y		No	ClinGen ExAC gnomAD
CA366521269 rs1376069332	236	R>G		No	ClinGen gnomAD
CA366521266 rs1304710615	236	R>T		No	ClinGen gnomAD
CA366521259 rs1358945679	237	E>G		No	ClinGen TOPMed
CA152240113 rs951618288	237	E>K		No	ClinGen Ensembl
CA366521232 rs1562367423	241	F>I		No	ClinGen Ensembl
CA4108658 rs763802273	242	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs202247759 CA366521222	242	Q>P		No	ClinGen gnomAD
CA152240107 rs202247759	242	Q>R		No	ClinGen gnomAD
CA4108657 rs755188301	243	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1302531250 CA366521215	243	K>R		No	ClinGen gnomAD
CA366521206 rs1377713500	244	F>C		No	ClinGen gnomAD
rs1174656150 CA366521194	246	T>A		No	ClinGen gnomAD
CA4108655 rs766755961	247	Q>H		No	ClinGen ExAC gnomAD
rs754029431 CA4108656	247	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA366521168 rs1420394608	250	L>F		No	ClinGen gnomAD
rs1250587686 CA366521164	251	E>K		No	ClinGen gnomAD
CA4108653 rs760804113	252	P>S		No	ClinGen ExAC gnomAD
CA366521142 rs1562367356	254	Q>E		No	ClinGen Ensembl
CA366521139 rs1484407566	254	Q>R		No	ClinGen TOPMed gnomAD
rs1293945573 CA366520865	256	L>F		No	ClinGen gnomAD
TCGA novel	260	R>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366520829 rs1562366728	261	G>A		No	ClinGen Ensembl
rs774703417 CA4108632	261	G>S		No	ClinGen ExAC TOPMed gnomAD
rs764705175 CA4108628	263	A>V		No	ClinGen ExAC TOPMed gnomAD
CA366520812 rs1390450965	264	P>L		No	ClinGen gnomAD
rs763226032 CA4108627	265	I>L		No	ClinGen ExAC gnomAD
CA152239304 rs912946476	265	I>T		No	ClinGen Ensembl
CA4108625 rs769380262	266	W>C		No	ClinGen ExAC TOPMed gnomAD
CA152239303 rs775892587	266	W>G		No	ClinGen ExAC TOPMed gnomAD
rs775892587 CA4108626	266	W>R		No	ClinGen ExAC TOPMed gnomAD
rs1421953451 CA366520782	269	G>D		No	ClinGen TOPMed
CA4108623 rs776080602	270	E>K		No	ClinGen ExAC TOPMed gnomAD
CA4108622 rs140553523	271	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs140573137 CA4108621	275	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA366520740 rs140573137	275	E>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4108620 rs777538268	277	D>G		No	ClinGen ExAC gnomAD
CA366520725 rs777538268	277	D>V		No	ClinGen ExAC gnomAD
rs1469953913 CA366520718	278	I>N		No	ClinGen gnomAD
rs1252067185 CA366520711	279	P>L		No	ClinGen gnomAD
rs747878373 CA4108618	280	D>G		No	ClinGen ExAC gnomAD
rs772112538 CA4108619	280	D>H		No	ClinGen ExAC TOPMed gnomAD
rs772112538 CA366520708	280	D>N		No	ClinGen ExAC TOPMed gnomAD
rs772112538 CA366520707	280	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs1331074417 CA366520662	286	K>N		No	ClinGen TOPMed gnomAD
CA4108578 rs774403635	294	M>L		No	ClinGen ExAC TOPMed gnomAD
CA366520533 rs1459366462	294	M>T		No	ClinGen TOPMed
CA366520515 rs1301151559	296	Q>H		No	ClinGen gnomAD
CA366520513 rs1444475662	297	L>V		No	ClinGen TOPMed gnomAD
rs1185276783 CA366520505	298	L>P		No	ClinGen gnomAD
CA4108576 rs749084257	303	A>T		No	ClinGen ExAC TOPMed gnomAD
rs140493653 CA366520459	305	R>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA152238433 rs140493653	305	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs140493653 COSM595314 CA4108574	305	R>T	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs977638677 CA152238428	306	L>V		No	ClinGen TOPMed
CA366520449 rs1214939626	307	G>D		No	ClinGen gnomAD
rs1231454593 CA366520435	309	S>N		No	ClinGen TOPMed
CA366520430 rs1401572089	310	I>V		No	ClinGen TOPMed gnomAD
rs747287336 CA4108573	312	W>*		No	ClinGen ExAC gnomAD
rs1364033868 CA366520409	312	W>C		No	ClinGen gnomAD
CA366520404 rs1270508409	313	G>D		No	ClinGen gnomAD
rs913520846 CA152238421	315	L>Q		No	ClinGen TOPMed
CA366520393 rs1562365999	315	L>V		No	ClinGen Ensembl
TCGA novel	316	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	316	A>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1439910012 CA366520384	317	V>I		No	ClinGen TOPMed
rs146748595 CA152238420	319	T>I		No	ClinGen ESP TOPMed gnomAD
rs1583138420 CA366520360	320	C>*		No	ClinGen Ensembl
rs377003096 CA4108570	320	C>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA4108571 rs377003096	320	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA152238404 rs975865539	321	A>G		No	ClinGen TOPMed
CA4108569 rs373713795	322	E>G		No	ClinGen ExAC TOPMed gnomAD
CA366520329 rs1477231650	325	S>C		No	ClinGen TOPMed
TCGA novel	327	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366520295 rs1583138403	327	G>D		No	ClinGen Ensembl
rs755535884 CA4108568	330	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs754140920 CA4108567	331	T>R		No	ClinGen ExAC gnomAD
CA366520247 rs1168476894	332	E>*		No	ClinGen gnomAD
CA366520203 rs766767936	334	F>C		No	ClinGen ExAC TOPMed gnomAD
rs766767936 CA366520199	334	F>S		No	ClinGen ExAC TOPMed gnomAD
CA4108566 rs766767936	334	F>Y		No	ClinGen ExAC TOPMed gnomAD
rs755678073 CA4108565	337	K>R		No	ClinGen ExAC gnomAD
CA366520145 rs1452965779	338	Q>*		No	ClinGen gnomAD
rs1255357725 CA366520117	340	V>I		No	ClinGen gnomAD
rs1237445612 CA366520081	342	D>E		No	ClinGen TOPMed gnomAD
rs188661022 CA4108563	342	D>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs372458890 CA4108561	343	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs372458890 CA152238361	343	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs142102398 CA4108558	344	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA4108559 rs768179250	344	P>R*		No	ClinGen ExAC
rs774065733 CA4108560	344	P>S		No	ClinGen ExAC gnomAD
CA4108554 rs769654228	345	P>Q		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q16342

2 regional properties for Q16342

Type	Name	Position	InterPro Accession
domain	Zinc finger, MYND-type	135 - 172	IPR002893
domain	Programmed cell death protein 2, C-terminal	238 - 339	IPR007320

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
enzyme binding	Binding to an enzyme, a protein with catalytic activity.
metal ion binding	Binding to a metal ion.

5 GO annotations of biological process

Name	Definition
activation of cysteine-type endopeptidase activity involved in apoptotic process	Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of hematopoietic stem cell proliferation	Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation.
regulation of hematopoietic progenitor cell differentiation	Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2YDC9	PDCD2	Programmed cell death protein 2	Bos taurus (Bovine)	PR

10	20	30	40	50	60
MAAAGARPVE	LGFAESAPAW	RLRSEQFPSK	VGGRPAWLGA	AGLPGPQALA	CELCGRPLSF
70	80	90	100	110	120
LLQVYAPLPG	RPDAFHRCIF	LFCCREQPCC	AGLRVFRNQL	PRKNDFYSYE	PPSENPPPET
130	140	150	160	170	180
GESVCLQLKS	GAHLCRVCGC	LGPKTCSRCH	KAYYCSKEHQ	TLDWRLGHKQ	ACAQPDHLDH
190	200	210	220	230	240
IIPDHNFLFP	EFEIVIETED	EIMPEVVEKE	DYSEIIGSMG	EALEEELDSM	AKHESREDKI
250	260	270	280	290	300
FQKFKTQIAL	EPEQILRYGR	GIAPIWISGE	NIPQEKDIPD	CPCGAKRILE	FQVMPQLLNY
310	320	330	340
LKADRLGKSI	DWGILAVFTC	AESCSLGTGY	TEEFVWKQDV	TDTP