AiPD: Autoinhibited Protein Database

Q15434

Gene name	RBMS2 (SCR3)
Protein name	RNA-binding motif, single-stranded-interacting protein 2
Names	Suppressor of CDC2 with RNA-binding motif 3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5939
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-74 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-74 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q15434

Entry ID	Method	Resolution	Chain	Position	Source
1X4E	NMR	-	A	58-129	PDB
AF-Q15434-F1	Predicted				AlphaFoldDB

315 variants for Q15434

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA385286425 rs1331064940	2	L>P		No	ClinGen gnomAD
rs1004433171 CA237658074	5	V>M		No	ClinGen TOPMed
CA6633421 rs771779362	6	T>I		No	ClinGen ExAC gnomAD
TCGA novel	8	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1354186973 CA385286633	9	P>R		No	ClinGen TOPMed
CA385286625 rs1216100826	9	P>S		No	ClinGen TOPMed
CA385286668 rs1232054517	10	G>E		No	ClinGen TOPMed
TCGA novel	13	T>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770512270 CA6633424	16	Y>H		No	ClinGen ExAC gnomAD
CA237658082 rs1011482042	17	N>D		No	ClinGen TOPMed
CA385286925 rs1456148151	17	N>S		No	ClinGen gnomAD
rs1287958482 CA385286982	19	N>D		No	ClinGen TOPMed
rs781172723	20	N>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA6633427 rs763520213	20	N>H		No	ClinGen ExAC gnomAD
rs764597829 CA6633428	20	N>K		No	ClinGen ExAC gnomAD
rs1290906580 CA385287085	22	K>T		No	ClinGen gnomAD
CA385299908 rs1291965453	24	Y>C		No	ClinGen TOPMed gnomAD
rs369110719 CA6633449	25	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA385299956 rs3759091	27	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs3759091 CA385299957	27	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6633451 rs772310200	30	Q>R		No	ClinGen ExAC gnomAD
CA385300018 rs1180877630	31	M>I		No	ClinGen gnomAD
rs773548497 CA6633452	31	M>L		No	ClinGen ExAC gnomAD
CA385300028 rs1378900514	32	A>S		No	ClinGen TOPMed gnomAD
rs1378900514 CA385300024	32	A>T		No	ClinGen TOPMed gnomAD
CA6633454 rs766494943	33	P>L		No	ClinGen ExAC TOPMed gnomAD
CA6633453 rs760856152	33	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1416612418 CA385300092	36	P>T		No	ClinGen gnomAD
rs1403088682 CA385300162	38	N>K		No	ClinGen gnomAD
rs753939467 CA6633455	39	S>G		No	ClinGen ExAC gnomAD
CA385300208 rs1448580487	41	P>S		No	ClinGen gnomAD
rs1304860504 CA385300267	43	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs200678301 CA237672116	44	S>G		No	ClinGen 1000Genomes
CA385300354 rs1328909570	46	G>R		No	ClinGen gnomAD
CA385300383 rs1432266521	47	S>N		No	ClinGen TOPMed
rs1245261936 CA385300424	48	N>K		No	ClinGen gnomAD
CA6633456 rs759574318	48	N>S		No	ClinGen ExAC TOPMed gnomAD
CA385300439 rs1285813413	49	G>A		No	ClinGen gnomAD
CA385300561 rs1404126233	52	Q>R		No	ClinGen gnomAD
rs1231515253 CA385300611	54	S>N		No	ClinGen gnomAD
rs563161140 CA6633457	54	S>R		No	ClinGen 1000Genomes ExAC gnomAD
CA6633458 rs752522063	55	K>Q		No	ClinGen ExAC gnomAD
rs1034294284 CA237672126	56	T>I		No	ClinGen gnomAD
CA385300649 rs1592429537	56	T>P		No	ClinGen Ensembl
CA6633459 rs758276334	57	N>K		No	ClinGen ExAC gnomAD
rs1236609177 CA385300727	59	Y>C		No	ClinGen TOPMed gnomAD
rs751301625 CA6633461	60	I>S		No	ClinGen ExAC gnomAD
rs138231675 CA6633462	61	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA6633463 rs780949661	61	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed
rs769127441 CA6633465	64	Q>P		No	ClinGen ExAC gnomAD
CA385300892 rs1423672327	66	G>A		No	ClinGen TOPMed gnomAD
rs1423672327 CA385300888	66	G>D		No	ClinGen TOPMed gnomAD
CA6633466 rs779530500	67	T>I		No	ClinGen ExAC TOPMed gnomAD
CA385300927 rs1301987999	68	T>I		No	ClinGen TOPMed
rs1020536701 CA237672143	69	D>V		No	ClinGen gnomAD
CA385301045 rs1338606041	73	V>D		No	ClinGen TOPMed gnomAD
CA237672146 rs966354874	73	V>I		No	ClinGen TOPMed gnomAD
rs966354874 CA385301032	73	V>L		No	ClinGen TOPMed gnomAD
rs979121670 CA385301089	74	K>N		No	ClinGen gnomAD
CA385301110 rs1318642757	76	C>R		No	ClinGen TOPMed gnomAD
rs1400347791 CA385301128	77	Q>*		No	ClinGen TOPMed
CA6633470 rs201891574	78	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1565764844 CA385302589	80	G>S		No	ClinGen Ensembl
CA385302645 rs1260484308	82	I>T		No	ClinGen gnomAD
rs775450277 CA385302653	83	V>F		No	ClinGen ExAC TOPMed gnomAD
rs775450277 CA6633496	83	V>I		No	ClinGen ExAC TOPMed gnomAD
CA6633497 rs777863145	88	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6633498 rs764129358	90	D>H		No	ClinGen ExAC gnomAD
rs368873647 CA6633500	91	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs767415046 CA6633501	92	T>A		No	ClinGen ExAC gnomAD
rs1288245355 CA385302836	93	T>I		No	ClinGen gnomAD
CA6633502 rs750139812	94	N>D		No	ClinGen ExAC gnomAD
CA6633503 rs755700399	96	C>S		No	ClinGen ExAC gnomAD
CA385302883 rs755700399	96	C>Y		No	ClinGen ExAC gnomAD
rs1254282139 CA385302924	98	G>C		No	ClinGen TOPMed
CA6633520 rs772904949	99	Y>N		No	ClinGen ExAC gnomAD
COSM941711 CA237673887 rs959792491	100	G>D	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA6633521 rs760480312	101	F>C		No	ClinGen ExAC gnomAD
TCGA novel	101	F>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6633522 rs765954581	102	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1246341719 CA385303176	102	V>I		No	ClinGen TOPMed gnomAD
CA385303200 rs1387166604	103	D>V		No	ClinGen gnomAD
CA385303237 rs1565766000	105	D>H		No	ClinGen Ensembl
rs1565766000 CA385303238	105	D>Y		No	ClinGen Ensembl
rs1565766040 COSM163962 CA385303342	108	S>L	breast [Cosmic]	No	ClinGen cosmic curated Ensembl
CA6633525 rs764725341	111	Q>*		No	ClinGen ExAC gnomAD
CA6633526 rs752104323	112	K>E		No	ClinGen ExAC gnomAD
CA385303474 rs1256757977	113	A>S		No	ClinGen gnomAD
rs757743610 CA6633527	114	V>E		No	ClinGen ExAC gnomAD
CA385303506 rs1320985711	115	T>A		No	ClinGen gnomAD
CA6633528 rs149875820	116	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA237673901 rs201031970	118	K>R		No	ClinGen 1000Genomes
rs1415717700 CA385303642	119	A>T		No	ClinGen gnomAD
CA385303689 rs1171582771	121	G>S		No	ClinGen TOPMed gnomAD
rs780196032 CA6633531	125	Q>*		No	ClinGen ExAC gnomAD
rs1240387400 CA385303888	125	Q>L		No	ClinGen TOPMed
rs1212156282 CA385303956	126	M>T		No	ClinGen TOPMed
CA237673908 rs113684472	126	M>V		No	ClinGen Ensembl
rs749520337 CA6633532	127	A>E		No	ClinGen ExAC gnomAD
CA6633533 rs768895279	128	K>Q		No	ClinGen ExAC gnomAD
CA385305242 rs1274469775	129	Q>K		No	ClinGen TOPMed
CA237674385 rs1023661888	131	E>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs969437887 CA237674387	137	L>V		No	ClinGen TOPMed
TCGA novel	141	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1592461699 CA385305626	141	N>T		No	ClinGen Ensembl
TCGA novel	143	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772223079 CA6633555	144	L>P		No	ClinGen ExAC gnomAD
CA237674392 rs149053812 COSM941713	146	M>I	endometrium [Cosmic]	No	ClinGen cosmic curated ESP TOPMed gnomAD
CA6633556 rs777631967	146	M>V		No	ClinGen ExAC gnomAD
rs1160401104 CA385305783	149	Q>*		No	ClinGen TOPMed
CA6633557 rs746964419	152	E>A		No	ClinGen ExAC gnomAD
rs993121089 CA237674395	152	E>K		No	ClinGen Ensembl
CA6633559 rs370696784	153	G>A		No	ClinGen ESP ExAC gnomAD
rs759282201 CA6633560	154	M>I		No	ClinGen ExAC gnomAD
rs775062304 CA6633562	160	Q>H		No	ClinGen ExAC gnomAD
CA6633563 rs762504244	162	I>M		No	ClinGen ExAC gnomAD
rs763653693 CA6633564	163	S>A		No	ClinGen ExAC gnomAD
TCGA novel	164	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs144330252 CA6633567	165	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs754285706 CA6633568	165	R>H		No	ClinGen ExAC TOPMed gnomAD
CA237674414 rs375595230	166	I>V		No	ClinGen ESP TOPMed
rs755327244 CA6633569	168	R>*		No	ClinGen ExAC TOPMed gnomAD
CA385306293 rs1445284168	168	R>Q		No	ClinGen gnomAD
CA385306421 rs1219504869	176	G>D		No	ClinGen TOPMed
CA6633571 rs752956765	176	G>R		No	ClinGen ExAC gnomAD
rs754909777 CA6633572	177	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1192108656 CA385306430	177	V>I		No	ClinGen gnomAD
rs778779594 CA237674429	178	G>S		No	ClinGen Ensembl
rs1160738799 CA385306511	180	A>V		No	ClinGen gnomAD
CA385331546 rs1212124104	182	M>T		No	ClinGen gnomAD
rs201186596 CA6633605	183	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs748980172 CA6633606	185	T>A		No	ClinGen ExAC gnomAD
rs1455873995 CA385331582	187	K>M		No	ClinGen TOPMed
rs1057388884 CA237665584	187	K>N		No	ClinGen Ensembl
rs747715678 CA6633609	196	N>S		No	ClinGen ExAC gnomAD
rs771459857 CA6633610	198	K>E		No	ClinGen ExAC gnomAD
TCGA novel	198	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777316431 CA6633611	202	T>A		No	ClinGen ExAC gnomAD
CA385331746 rs765752056	204	P>A		No	ClinGen ExAC gnomAD
CA385331752 rs1445818077	204	P>R		No	ClinGen TOPMed
rs765752056 CA385331748	204	P>S		No	ClinGen ExAC gnomAD
rs765752056 CA6633613	204	P>T		No	ClinGen ExAC gnomAD
rs371720843 CA6633614	205	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs945144527 CA237665623	205	G>R		No	ClinGen TOPMed
CA385331783 rs1434076333	207	P>S		No	ClinGen gnomAD
rs1384501933 CA385331849	209	P>S		No	ClinGen TOPMed gnomAD
rs746458217 CA6633630	210	S>P		No	ClinGen ExAC TOPMed gnomAD
CA237665679 rs746458217	210	S>T		No	ClinGen ExAC TOPMed gnomAD
rs776096624 CA6633632	211	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA237665699 rs1015725989	213	L>F		No	ClinGen TOPMed
rs575794871 CA385331960	216	K>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6633634 rs575794871	216	K>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs575794871 CA237665703	216	K>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA385332000 rs1236212471	219	D>V		No	ClinGen gnomAD
CA385332005 rs1259680651	220	G>C		No	ClinGen gnomAD
TCGA novel	221	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761930252 CA6633636 COSM549168	221	G>R	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs750508627 CA6633638	224	K>E		No	ClinGen ExAC gnomAD
CA6633639 rs750508627	224	K>Q		No	ClinGen ExAC gnomAD
rs146998541 CA6633640	225	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs146998541 CA6633641	225	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs754841950 CA6633642	225	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1252546133 CA385332042	226	Q>*		No	ClinGen gnomAD
rs1283710555 CA385332047	226	Q>R		No	ClinGen TOPMed
rs1223178186 CA385332058	227	N>D		No	ClinGen TOPMed
CA385332093 rs1181031412	229	G>R		No	ClinGen gnomAD
rs752450975 CA385332131	231	F>S		No	ClinGen ExAC gnomAD
rs752450975 CA6633644	231	F>Y		No	ClinGen ExAC gnomAD
rs371906296 CA6633645	233	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs371906296 CA385332153	233	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1344540964 CA385332185	234	N>K		No	ClinGen TOPMed
rs746546309 CA6633648	236	R>L		No	ClinGen ExAC gnomAD
CA6633649 rs746546309	236	R>Q		No	ClinGen ExAC gnomAD
rs376730098 CA237665752	236	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
CA237665757 rs983829248	237	A>T		No	ClinGen Ensembl
rs1390117559 CA385332217	237	A>V		No	ClinGen TOPMed gnomAD
rs1316797163 CA385332295	242	A>E		No	ClinGen TOPMed
CA385332289 rs1358111690	242	A>T		No	ClinGen TOPMed
rs780654306 CA6633650	244	M>R		No	ClinGen ExAC TOPMed gnomAD
rs148057149	245	G>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA6633671 rs779436719	245	G>D		No	ClinGen ExAC gnomAD
CA385332377 rs1592498288	245	G>S		No	ClinGen Ensembl
CA6633673 rs140900217	246	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	248	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs909802034 CA237665929	248	A>V		No	ClinGen TOPMed gnomAD
rs747227545 CA6633675	251	Y>C		No	ClinGen ExAC gnomAD
CA6633677 rs374424918	253	P>A		No	ClinGen ESP ExAC gnomAD
rs1204812384 CA385332580	255	T>I		No	ClinGen TOPMed
rs750923101 CA237665950	256	A>G		No	ClinGen Ensembl
CA385332585 rs1427091434	256	A>P		No	ClinGen TOPMed gnomAD
rs749702342 CA385332610	257	L>F		No	ClinGen ExAC TOPMed gnomAD
rs749702342 CA6633680	257	L>I		No	ClinGen ExAC TOPMed gnomAD
rs749702342 CA385332607	257	L>V		No	ClinGen ExAC TOPMed gnomAD
CA385332670 rs1437075052	260	G>R		No	ClinGen gnomAD
rs1343050040 CA385332809	261	F>C		No	ClinGen gnomAD
rs768659830 CA6633699	262	Y>F		No	ClinGen ExAC gnomAD
CA6633698 rs150186901	262	Y>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6633700 rs774295449	263	P>S		No	ClinGen ExAC gnomAD
rs186378788 CA237666024	264	A>D		No	ClinGen 1000Genomes
TCGA novel	266	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767099663 CA6633703	269	T>I		No	ClinGen ExAC TOPMed gnomAD
CA385333001 rs767099663	269	T>N		No	ClinGen ExAC TOPMed gnomAD
CA6633705 rs760144097	270	P>H		No	ClinGen ExAC TOPMed gnomAD
rs765907785 CA6633706	271	N>D		No	ClinGen ExAC TOPMed gnomAD
CA385333077 rs1470097734	272	R>K		No	ClinGen gnomAD
CA6633707 rs376412635	273	M>V		No	ClinGen ESP ExAC gnomAD
CA385333210 rs1179485357	279	L>F		No	ClinGen gnomAD
CA237666040 rs1029843608	280	S>F		No	ClinGen Ensembl
CA237666044 rs886915854	281	P>S		No	ClinGen TOPMed gnomAD
CA6633711 rs757589853	283	L>F		No	ClinGen ExAC TOPMed gnomAD
CA6633715 rs780297509	285	S>C		No	ClinGen ExAC gnomAD
rs558330150 CA6633714	285	S>T		No	ClinGen 1000Genomes ExAC gnomAD
rs749316781 CA385333319	286	P>A		No	ClinGen ExAC TOPMed gnomAD
rs749316781 CA6633716 COSM1705821	286	P>S	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6633717 rs768746099	288	S>C		No	ClinGen ExAC TOPMed gnomAD
CA385333391 rs1444248926	289	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs371212744 CA6633719	290	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA385335495 rs1216744688	292	R>T		No	ClinGen gnomAD
rs749403082 CA6633734	293	V>M		No	ClinGen ExAC TOPMed gnomAD
CA6633735 rs755088135	294	T>I		No	ClinGen ExAC gnomAD
rs779034318 CA6633736	298	P>S		No	ClinGen ExAC gnomAD
TCGA novel	298	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748112921 CA6633738	302	P>L		No	ClinGen ExAC gnomAD
CA6633739 rs771819658	304	P>S		No	ClinGen ExAC gnomAD
rs867745346 CA237668204	305	S>F		No	ClinGen Ensembl
CA6633740 rs773073425	306	W>R		No	ClinGen ExAC
CA237668207 rs953613172	308	H>L		No	ClinGen TOPMed
CA6633741 rs746713569	308	H>Q		No	ClinGen ExAC gnomAD
CA385335654 rs1592513831	309	H>P		No	ClinGen Ensembl
CA385335664 rs1476268518	309	H>Q		No	ClinGen gnomAD
CA6633743 rs770600714	310	H>P		No	ClinGen ExAC gnomAD
CA6633742 rs770600714	310	H>R		No	ClinGen ExAC gnomAD
rs759093964 CA6633745	312	Y>S		No	ClinGen ExAC gnomAD
CA385335775 rs1001477956	316	P>A		No	ClinGen TOPMed
CA237668256 rs1001477956	316	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA385335798 rs1325231314	317	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1159728872 CA385335850	318	G>C		No	ClinGen gnomAD
CA385335872 rs1364851702	322	T>S		No	ClinGen gnomAD
CA385335886 rs1315066069	324	G>E		No	ClinGen TOPMed
CA385335902 rs1442179980	326	D>G		No	ClinGen gnomAD
TCGA novel	326	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1329900644 CA385335910	327	H>R		No	ClinGen gnomAD
rs768094845 CA6633767	329	I>L		No	ClinGen ExAC gnomAD
CA6633768 rs773572162	331	L>F		No	ClinGen ExAC TOPMed gnomAD
rs748814186 CA237668541	333	P>H		No	ClinGen Ensembl
CA385335996 rs1195340347	336	M>I		No	ClinGen gnomAD
rs754171343 CA6633771	336	M>L		No	ClinGen ExAC TOPMed gnomAD
rs754171343 CA385335982	336	M>V		No	ClinGen ExAC TOPMed gnomAD
CA237668556 rs758292824	337	M>I		No	ClinGen Ensembl
rs755263749 CA6633772	338	G>E		No	ClinGen ExAC gnomAD
CA385336040 rs1304280681	339	P>L		No	ClinGen gnomAD
CA237668564 rs1054058727	339	P>S		No	ClinGen TOPMed
rs1432569629 CA385336044	340	L>F		No	ClinGen gnomAD
rs778605724 CA6633775	342	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA6633776 rs146335313	346	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA237668569 rs988642224	347	L>V		No	ClinGen Ensembl
CA385336119 rs1462265768	348	S>F		No	ClinGen gnomAD
rs913141941 CA237668573	352	T>I		No	ClinGen TOPMed
rs374841391	354	T>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs200554259 CA237668577	354	T>M		No	ClinGen TOPMed gnomAD
CA385336230 rs1310158451	355	Y>C		No	ClinGen gnomAD
CA6633797 rs750245524	356	M>T		No	ClinGen ExAC gnomAD
rs147777758 CA6633798	357	P>L	Variant assessed as Somatic; 4.623e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA385336245 COSM941716 rs1432054112	357	P>S	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA6633801 rs375943823	358	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6633800 rs375943823	358	T>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs747593096 CA6633803	362	M>K		No	ClinGen ExAC gnomAD
rs747593096 CA385336277	362	M>R		No	ClinGen ExAC gnomAD
rs747593096 CA6633804	362	M>T		No	ClinGen ExAC gnomAD
rs777228521 CA6633805	365	A>V		No	ClinGen ExAC gnomAD
CA385336328 rs1183756984	366	Y>C		No	ClinGen gnomAD
CA385336324 rs1440857303	366	Y>H		No	ClinGen TOPMed
CA6633807 rs148793349	367	I>V		No	ClinGen ESP ExAC TOPMed
rs775844205 CA6633808	369	Q>E		No	ClinGen ExAC gnomAD
rs954749575 CA237669023	371	T>A		No	ClinGen TOPMed gnomAD
CA6633810 rs764316068	371	T>I		No	ClinGen ExAC gnomAD
CA237669029 rs954749575	371	T>S		No	ClinGen TOPMed gnomAD
CA237669037 rs368884447	373	V>L		No	ClinGen ESP TOPMed
rs989211939 CA237669042	375	S>P		No	ClinGen TOPMed
CA237669046 rs913624656	377	S>G		No	ClinGen TOPMed
CA385336429 rs1415668922	377	S>N		No	ClinGen TOPMed
rs1565786107 CA385336434	378	V>I		No	ClinGen Ensembl
rs750333517 CA6633814	380	V>D		No	ClinGen ExAC gnomAD
rs753613023 CA6633817	381	E>G		No	ClinGen ExAC gnomAD
rs201299402 CA6633816	381	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA6633839 rs752366248	382	E>G		No	ClinGen ExAC
rs1565786738 CA385336964	383	S>G		No	ClinGen Ensembl
rs377246241 CA6633840	383	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA6633841 rs777404766	384	S>N		No	ClinGen ExAC gnomAD
CA6633843 rs756580562	385	G>S		No	ClinGen ExAC TOPMed gnomAD
rs921060158 CA237669387	387	Q>E		No	ClinGen Ensembl
CA6633844 rs780564406	392	V>G		No	ClinGen ExAC gnomAD
rs1190012442 CA385337025	392	V>M		No	ClinGen gnomAD
rs749666279 CA6633845	393	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1050943172 CA237669407 COSM694448	394	A>T	lung large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs761746341 CA237669411	395	P>L		No	ClinGen gnomAD
rs761746341 CA385337046	395	P>R		No	ClinGen gnomAD
rs1434155038 CA385337056	397	E>G		No	ClinGen gnomAD
CA6633848 rs150502597	397	E>Q		No	ClinGen ESP ExAC gnomAD
rs532061418 CA6633850	398	H>D		No	ClinGen 1000Genomes ExAC gnomAD
rs532061418 CA237669422	398	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs760767462 CA6633851	399	G>R		No	ClinGen ExAC gnomAD
rs766247638 CA6633852	400	V>A		No	ClinGen ExAC gnomAD
rs766247638 CA385337084	400	V>G		No	ClinGen ExAC gnomAD
CA237669449 rs767797932	401	Y>C		No	ClinGen gnomAD
rs1387631392 CA385337089	401	Y>H		No	ClinGen gnomAD
rs776608607 CA6633854	402	S>C		No	ClinGen ExAC gnomAD
rs776608607 CA6633853	402	S>F		No	ClinGen ExAC gnomAD
CA237669463 rs939894250	403	F>L		No	ClinGen TOPMed gnomAD
CA237669464 rs140314358	403	F>S		No	ClinGen ESP
rs1307798409 CA385337160	405	F>L		No	ClinGen TOPMed
rs1393003742 CA385337174	405	F>L		No	ClinGen TOPMed
CA385337167 rs1246700391	405	F>S		No	ClinGen gnomAD
CA385337187 rs1388518491	406	N>S		No	ClinGen TOPMed
CA6633857 rs762705065	407	K>N		No	ClinGen ExAC gnomAD

No associated diseases with Q15434

2 regional properties for Q15434

Type	Name	Position	InterPro Accession
domain	RNA recognition motif domain	56 - 129	IPR000504-1
domain	RNA recognition motif domain	135 - 220	IPR000504-2

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex	A macromolecular complex that contains both RNA and protein molecules.

4 GO annotations of molecular function

Name	Definition
mRNA 3'-UTR binding	Binding to a 3' untranslated region of an mRNA molecule.
poly(A) binding	Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
poly(U) RNA binding	Binding to a sequence of uracil residues in an RNA molecule.
RNA binding	Binding to an RNA molecule or a portion thereof.

1 GO annotations of biological process

Name	Definition
RNA processing	Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MLLSVTSRPG	ISTFGYNRNN	KKPYVSLAQQ	MAPPSPSNST	PNSSSGSNGN	DQLSKTNLYI
70	80	90	100	110	120
RGLQPGTTDQ	DLVKLCQPYG	KIVSTKAILD	KTTNKCKGYG	FVDFDSPSAA	QKAVTALKAS
130	140	150	160	170	180
GVQAQMAKQQ	EQDPTNLYIS	NLPLSMDEQE	LEGMLKPFGQ	VISTRILRDT	SGTSRGVGFA
190	200	210	220	230	240
RMESTEKCEA	IITHFNGKYI	KTPPGVPAPS	DPLLCKFADG	GPKKRQNQGK	FVQNGRAWPR
250	260	270	280	290	300
NADMGVMALT	YDPTTALQNG	FYPAPYNITP	NRMLAQSALS	PYLSSPVSSY	QRVTQTSPLQ
310	320	330	340	350	360
VPNPSWMHHH	SYLMQPSGSV	LTPGMDHPIS	LQPASMMGPL	TQQLGHLSLS	STGTYMPTAA
370	380	390	400
AMQGAYISQY	TPVPSSSVSV	EESSGQQNQV	AVDAPSEHGV	YSFQFNK