Q14DL0

PR
Gene name
Ubqlnl
Protein name
Ubiquilin-like protein
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:244179
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q14DL0

Entry ID Method Resolution Chain Position Source
2DNA NMR - A 557-610 PDB
AF-Q14DL0-F1 Predicted AlphaFoldDB

54 variants for Q14DL0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs31908074 17 T>P No EVA
rs3388934328 51 L>F No EVA
rs31907341 58 I>M No EVA
rs3388891858 65 C>S No EVA
rs254570464 82 H>Y No EVA
rs3388905135 95 I>F No EVA
rs31907338 106 P>A No EVA
rs3388921264 112 S>Y No EVA
rs3388931943 113 F>L No EVA
rs3388891787 120 N>D No EVA
rs241778216 132 S>C No EVA
rs255491989 142 N>S No EVA
rs248416324 145 K>I No EVA
rs31906406 163 S>G No EVA
rs3388925947 174 Q>* No EVA
rs3413022378 179 L>R No EVA
rs31906404 196 P>Q No EVA
rs3388935641 201 M>L No EVA
rs3388926011 247 P>H No EVA
rs31905601 256 F>Y No EVA
rs3388934567 267 N>Y No EVA
rs3388935645 271 Q>H No EVA
rs31905598 284 V>A No EVA
rs3388921200 309 S>T No EVA
rs3388925986 316 Q>L No EVA
rs3388931946 319 W>* No EVA
rs3388931944 326 Q>H No EVA
rs232932041 345 P>S No EVA
rs3388931769 353 R>D No EVA
rs3388912334 353 R>G No EVA
rs3388915372 355 N>S No EVA
rs3388932171 356 P>S No EVA
rs3388905118 362 Q>R No EVA
rs3388934770 376 I>V No EVA
rs3388934568 378 V>L No EVA
rs3388915363 380 P>L No EVA
rs31904640 383 S>P No EVA
rs235941672 387 K>E No EVA
rs31904637 390 V>F No EVA
rs31904637 390 V>I No EVA
rs256444705 395 T>A No EVA
rs3388934619 399 G>D No EVA
rs3388905066 402 D>A No EVA
rs13479441 423 G>R No EVA
rs3388927855 433 Q>K No EVA
rs3388934636 441 L>I No EVA
rs3388934773 445 S>F No EVA
rs31107580 445 S>P No EVA
rs3388891869 457 T>S No EVA
rs31912117 460 Q>H No EVA
rs3398212643 504 Y>C No EVA
rs31912114 517 S>G No EVA
rs3388927910 548 Q>E No EVA
rs254600167 553 P>L No EVA

No associated diseases with Q14DL0

1 regional properties for Q14DL0

Type Name Position InterPro Accession
domain Ubiquitin-like domain 31 - 105 IPR000626

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

1 GO annotations of molecular function

Name Definition
polyubiquitin modification-dependent protein binding Binding to a protein upon poly-ubiquitination of the target protein.

1 GO annotations of biological process

Name Definition
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9NRR5 UBQLN4 Ubiquilin-4 Homo sapiens (Human) PR
Q5XIP4 Ubqlnl Ubiquilin-like protein Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MPRIISRSPK MPQSRYTAGV PADGKISPGV IRVIVKTPGN QIIFTVADDT LVRQFKEILS
70 80 90 100 110 120
AHFKCQMEQL VLVFMGRLLK DHDTLSQRGI TDGHIIHVVI KSKHGPRSLA HSFRNLVTNN
130 140 150 160 170 180
PCHQDRNPKG NSSMVCQSAG MNETKVESSL LMEPEAPKVG TESPEVGSLE HIAQVLENLC
190 200 210 220 230 240
VQSLLSNMDF VHQMPPEQPY MEELIQQNPE VSHLLDNSEI LCQTLELVRH LAIIQEIMQI
250 260 270 280 290 300
QQPAQNPEYP PNSQPFLGLE TVPNGNNHLG QSYVNNNDHM LNGVPDLLEG NCFTALLDEQ
310 320 330 340 350 360
VLEQVQTPSL SQPLPQEQWD QLSSSQVIYA NSCGLSSITP TNATPNHTNN VSRENPAIVA
370 380 390 400 410 420
TQGQSNVCAV QQPAEIPVLP TISINQKPQV DKDTTITLGI SDQWLEEDLQ QSDDQTSSQI
430 440 450 460 470 480
TGGMIQLLRN HPQMAAQMLL LMNTSQLNEQ WRQETPTPLQ SSQLHDLLLA LANPKTSQAL
490 500 510 520 530 540
LQIEHGLQLL ATEAPALLPY IEPYLWGLGW LIPSICSYPD IVPWTWNVQD MAEPQCPESC
550 560 570 580 590 600
HKSETVLQKV QPPSGDPSHS LQAPEVRFSK EMECLQAMGF VNYNANLQAL IATDGDTNAA
IYKLKSSQGF