Q14C51
Gene name |
Ptcd3 (Mrps39) |
Protein name |
Pentatricopeptide repeat domain-containing protein 3, mitochondrial |
Names |
28S ribosomal protein S39, mitochondrial, MRP-S39 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:69956 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for Q14C51
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7PNT | EM | 319 A | 4 | 1-685 | PDB |
| 7PNU | EM | 306 A | 4 | 1-685 | PDB |
| 7PNV | EM | 306 A | 4 | 1-685 | PDB |
| 7PNW | EM | 309 A | 4 | 1-685 | PDB |
| AF-Q14C51-F1 | Predicted | AlphaFoldDB |
53 variants for Q14C51
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs231317056 | 7 | A>V | No | EVA | |
| rs3396957549 | 70 | A>P | No | EVA | |
| rs30697183 | 74 | A>G | No | EVA | |
| rs3388825381 | 84 | T>I | No | EVA | |
| rs3388834416 | 94 | P>H | No | EVA | |
| rs225484579 | 97 | I>M | No | EVA | |
| rs30267257 | 102 | L>V | No | EVA | |
| rs3388828462 | 123 | N>K | No | EVA | |
| rs3396820583 | 148 | P>L | No | EVA | |
| rs3388813802 | 192 | L>F | No | EVA | |
| rs3388834375 | 201 | D>G | No | EVA | |
| rs3388831122 | 203 | E>D | No | EVA | |
| rs3388834361 | 203 | E>G | No | EVA | |
| rs3388828517 | 203 | E>K | No | EVA | |
| rs3388834573 | 218 | N>H | No | EVA | |
| rs3388839126 | 224 | E>K | No | EVA | |
| rs259673686 | 236 | P>L | No | EVA | |
| rs3388835644 | 263 | R>* | No | EVA | |
| rs46947437 | 277 | V>L | No | EVA | |
| rs13463078 | 279 | T>A | No | EVA | |
| rs229088333 | 302 | F>L | No | EVA | |
| rs260512068 | 303 | I>T | No | EVA | |
| rs3388822797 | 306 | E>A | No | EVA | |
| rs237971441 | 313 | N>T | No | EVA | |
| rs30693543 | 332 | Q>H | No | EVA | |
| rs249287340 | 336 | T>I | No | EVA | |
| rs3388831095 | 337 | I>M | No | EVA | |
| rs3388832315 | 355 | I>K | No | EVA | |
| rs3388801983 | 362 | I>F | No | EVA | |
| rs3388818572 | 363 | G>E | No | EVA | |
| rs3397064336 | 380 | P>Q | No | EVA | |
| rs3396911119 | 380 | P>T | No | EVA | |
| rs3388835159 | 383 | L>* | No | EVA | |
| rs216104963 | 385 | A>T | No | EVA | |
| rs245413692 | 386 | I>V | No | EVA | |
| rs3388839819 | 391 | L>P | No | EVA | |
| rs229270989 | 406 | S>C | No | EVA | |
| rs30066928 | 413 | G>D | No | EVA | |
| rs3396911097 | 424 | S>* | No | EVA | |
| rs245546903 | 443 | D>N | No | EVA | |
| rs30664375 | 454 | R>C | No | EVA | |
| rs30610713 | 456 | V>I | No | EVA | |
| rs3396957563 | 468 | L>V | No | EVA | |
| rs30690874 | 504 | N>S | No | EVA | |
| rs3388835210 | 510 | P>L | No | EVA | |
| rs3388839850 | 541 | P>L | No | EVA | |
| rs30688074 | 563 | S>G | No | EVA | |
| rs30687220 | 589 | S>T | No | EVA | |
| rs4225989 | 603 | K>N | No | EVA | |
| rs3388835696 | 618 | A>T | No | EVA | |
| rs3388835186 | 635 | S>R | No | EVA | |
| rs3388839832 | 643 | E>D | No | EVA | |
| rs30690719 | 668 | E>V | No | EVA |
No associated diseases with Q14C51
1 regional properties for Q14C51
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Pentatricopeptide repeat | 330 - 378 | IPR002885 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrial small ribosomal subunit | The smaller of the two subunits of a mitochondrial ribosome. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ribosomal small subunit binding | Binding to a small ribosomal subunit. |
| rRNA binding | Binding to a ribosomal RNA. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial translation | The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. |
| regulation of translation | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96EY7 | PTCD3 | Pentatricopeptide repeat domain-containing protein 3, mitochondrial | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAAAVAARR | LSFRSGLVLL | QTTRGTGVCE | PKVCCRFYAG | TESLPKVEGS | DITGIEEIVI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PKKKTWDKVA | VLQALASTVN | RDPTAAPYVF | HDDPYLIPTS | ALESRSFLLA | KKSGETAAKF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IINSYPKYFQ | KDIAEPHIPC | LMPEYFEPQI | EDVSEAALEE | RIRLRKVRAS | VDMFDQLLQA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GTTVSLETTN | SLLDLLCYYG | DQEPPADYPF | QQTEHLENLE | EAAEENNQTS | KMESGPWKAQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NNAERIFALM | PEKNARSYCT | MIRGMVKHRA | YAQALNVYTE | LLNNRLSADV | YTFNALIEAK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TFILNEKFEE | KWNDILDLLK | HMVAQKVKPN | LQTFNTILKG | LRKCYSLGRI | PALQILREMK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HIGIEPSLAT | YHHIIHLFYP | RDLSAIKMPS | LIIYDIMNEL | EGRTFSPQDL | DDGRFFQLAM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SVCSSLRDLE | LAYQVHRLLN | TGDNRKLVGH | DPLRKVYYSK | FFSLICSLEQ | IDVTLKWYKD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LIPSVFLPHY | QIFIGLLQAL | DVANRLELVP | QIWKDSKEYS | HTFRDALREE | VLMLMARDKH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PPELQVAFAD | CAADIKSTYE | DQSARQPAFD | WPANPLQYIA | VLFLRGGRSQ | EAWKMLELFK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KHKKIPRNEL | LEEFMDTAKA | SGSTALAIEV | VKLASAFSLP | IGESLAQRVV | MDFTVDPEQK |
| 670 | 680 | ||||
| EALGNLTELN | SSDGESSSDS | DSDDK |