Q12SG0

PR
Gene name
folE
Protein name
GTP cyclohydrolase 1
Names
GTP cyclohydrolase I, GTP-CH-I
Species
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
KEGG Pathway
sdn:Sden_0321
EC number
3.5.4.16: In cyclic amidines
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q12SG0

Entry ID Method Resolution Chain Position Source
AF-Q12SG0-F1 Predicted AlphaFoldDB

No variants for Q12SG0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q12SG0

No associated diseases with Q12SG0

4 regional properties for Q12SG0

Type Name Position InterPro Accession
domain ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain 144 - 353 IPR000194
domain AAA+ ATPase domain 156 - 337 IPR003593
active_site ATPase, alpha/beta subunit, nucleotide-binding domain, active site 344 - 353 IPR020003
domain T3SS EscN ATPase, C-terminal 361 - 431 IPR040627

Functions

Description
EC Number 3.5.4.16 In cyclic amidines
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTP cyclohydrolase I activity Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate.
zinc ion binding Binding to a zinc ion (Zn).

3 GO annotations of biological process

Name Definition
7,8-dihydroneopterin 3'-triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate.
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
tetrahydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALSDAAIKV QAALNERGLE TPMLPKTSTP EERKIKIEHH MREILTLMSL DLTDDSLMDT
70 80 90 100 110 120
PRRIAKMYVD EIFSGLDYDN FPKITVIDNK MGFDEMVRVQ DISLTSTCEH HLVTIDGLAT
130 140 150 160 170 180
VAYLPRAKII GLSKINRIVR FFAQRPQVQE RLTQQILVAL QTLLETKDVA VKIDAVHFCV
190 200 210
KSRGVMDSTS STTTTSLGGI FKSNPATRAE FLQQAKF