Q12PX7

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
KEGG Pathway
sdn:Sden_1213
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

394-471 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q12PX7

Entry ID Method Resolution Chain Position Source
AF-Q12PX7-F1 Predicted AlphaFoldDB

No variants for Q12PX7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q12PX7

No associated diseases with Q12PX7

4 regional properties for Q12PX7

Type Name Position InterPro Accession
domain DHHA1 domain 732 - 869 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 651 - 694 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 553 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 3 - 707 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFETTAKLRS AFLAYFETQG HQVVDSSSLV PHNDPTLLFT NAGMNQFKDV FLGMDKRSYS
70 80 90 100 110 120
RAVSSQRCVR AGGKHNDLDN VGYTARHHTF FEMLGNFSFG DYFKEEAIRF AWTFLTETLK
130 140 150 160 170 180
LPTERLCVTI YETDDEAFEL WNKKIGVAAE NIIRIGDNKG APYASDNFWQ MGDTGPCGPC
190 200 210 220 230 240
SEIFYDHGDH IWGGRPGTPE EDGDRFIEIW NIVFMQYNRQ ADGAMLPLPK PSVDTGMGIE
250 260 270 280 290 300
RIAAIMQGVH SNYEIDIFKQ LIAKTAEIIG VSDLENKSLR VIADHIRSCA FLIADGVMPS
310 320 330 340 350 360
NEGRGYVLRR IIRRAVRHGN KLGATDTFFY KLVPTLISVM GDAAKGLVET QVIVEKALKA
370 380 390 400 410 420
EEEQFARTLE RGLGLLDNAL NELSGKVLDG DTAFKLYDTY GFPVDLTADV CRERDITVDE
430 440 450 460 470 480
AGFEAAMAEQ RSRAQAAGNF GADYNKQLII DEETQFCGYK GLSGEANVVA LYLDGQAVNE
490 500 510 520 530 540
VTQGQDAVVV LNNTPFYAES GGQVGDKGVL SAQGINFSVT DTQKFGQATG HQGKVLEGSI
550 560 570 580 590 600
KVGTKLAAEV NKDLRQRTEL NHSVTHLLHA ALRQVIGTHV TQKGSLVNPE RLRFDFAHFE
610 620 630 640 650 660
GVKAAELKQV EELVNAQIRC NHELNTAEMA IDEAKEKGAM ALFGEKYDEK VRVVTMGDFS
670 680 690 700 710 720
IELCGGTHVG RTGDIGLFKI TSEAGIAAGV RRIEAVTGAA AMAYVAEQQA MLDEAAGLLK
730 740 750 760 770 780
SDSASVVAKL KAQLDKTKQL EKELSQLKDK LAAAASADMA GDAQDINGVK VLVKKLEGVD
790 800 810 820 830 840
PGSLRGLQDE LKQKLKSAII LLGTAKDGKV NLIAGVSNDL TAKVKAGELV AMVAQQVGGK
850 860 870
GGGRPDMAQA GGTQVENLDA ALASASTWIA ERLA