Q12C33

PR
Gene name
msbA
Protein name
ATP-dependent lipid A-core flippase
Names
Lipid A export ATP-binding/permease protein MsbA
Species
Polaromonas sp (strain JS666 / ATCC BAA-500)
KEGG Pathway
pol:Bpro_1979
EC number
7.5.2.6: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q12C33

Entry ID Method Resolution Chain Position Source
AF-Q12C33-F1 Predicted AlphaFoldDB

No variants for Q12C33

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q12C33

No associated diseases with Q12C33

4 regional properties for Q12C33

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 350 - 584 IPR003439
domain AAA+ ATPase domain 376 - 561 IPR003593
domain ABC transporter type 1, transmembrane domain 37 - 318 IPR011527
conserved_site ABC transporter-like, conserved site 487 - 501 IPR017871

Functions

Description
EC Number 7.5.2.6 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled lipid transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTQLSEPVPV SLAARRSLWQ RVARVWPYFS GSRAGWALAI GATIVASATE PFVPALLKPL
70 80 90 100 110 120
LDRGFQRDSF NLWLVPLALM LLFTVRGLSG FLAQFALAKV TNDGLLKLRG AMFDKLLSAR
130 140 150 160 170 180
LTLFADQSSS AIANTVVYEV FNGSSMLINA IMKLARDVLT LLALIGYLVY LNWKLMLVVA
190 200 210 220 230 240
LLFPAVAFVI QVLSKRLYRL TKESQTATDD LAYVVEENVM AHRDVRLHGA QAGQASRFNH
250 260 270 280 290 300
LSNSLRRLSM KSTAAYAGMS AITQVLAAMA LSAVISIALL QSAENTTTVG GFVAFVTAML
310 320 330 340 350 360
LLIAPVKSLS DAATPVTRGL AALERGLDLM NLTPDESGGS FVKARAHGDI EFADVSVIYK
370 380 390 400 410 420
ADAAAALDQF SLSIKAGETL AIVGASGSGK TTLVNLLPRF VEMSSGNIYL DGQDLRAWNL
430 440 450 460 470 480
ASLRAQFAFV SQHVVMLNNS IAVNVALGQP VDRARVTECL AAANLSGLLA ELPGGIDTIL
490 500 510 520 530 540
GHNAMQLSGG QRQRLAIARA LYKNAPILVL DEATSALDTE SELAVQEAIK RLTASRTSLV
550 560 570 580
IAHRLSTVQH ADRIIMMEAG RMIESGTHAE LLARNGAYAH LYRLGFRNT