AiPD: Autoinhibited Protein Database

Gene name	SEC39
Protein name	Protein transport protein SEC39
Names	Dependent on SLY1-20 protein 3
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YLR440C
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

28-137 (Predicted disordered autoinhibitory region) PR

28-137 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
3K8P	X-ray	260 A	D	1-709	PDB
8EKI	EM	450 A	D	1-709	PDB
AF-Q12745-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s12-1017628	23	K>E	No	SGRP
s12-1017593	34	K>N	No	SGRP
s12-1017466	77	V>I	No	SGRP
s12-1017450	82	S>N	No	SGRP
s12-1017445	84	S>G	No	SGRP
s12-1017420	92	S>N	No	SGRP
s12-1017348	116	T>I	No	SGRP
s12-1017333	121	E>V	No	SGRP
s12-1017078	206	G>E	No	SGRP
s12-1017049	216	D>N	No	SGRP
s12-1017049	216	D>Y	No	SGRP
s12-1016979	239	Q>R	No	SGRP
s12-1016901	265	D>G	No	SGRP
s12-1016755	314	I>L	No	SGRP
s12-1016740	319	T>A	No	SGRP
s12-1016611	362	L>I	No	SGRP
s12-1016588	369	K>N	No	SGRP
s12-1016544	384	V>A	No	SGRP
s12-1016544	384	V>D	No	SGRP
s12-1016527	390	D>H	No	SGRP
s12-1016450	415	E>D	No	SGRP
s12-1016405	430	N>K	No	SGRP
s12-1016406	430	N>T	No	SGRP
s12-1016246	483	K>N	No	SGRP
s12-1016235	487	L>W	No	SGRP
s12-1016182	505	H>Y	No	SGRP
s12-1016009	562	E>D	No	SGRP
s12-1015908	596	V>A	No	SGRP
s12-1015595	700	R>S	No	SGRP

Type	Name	Position	InterPro Accession
domain	Sec39 domain	7 - 686	IPR013244

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
Dsl1/NZR complex	A multisubunit tethering complex, i.e. a protein complex involved in mediating the initial interaction between vesicles and the membranes with which they fuse, that is involved in trafficking from the Golgi apparatus to the ER. In Saccharomyces cerevisiae the Dsl1p complex contains Dsl1p, Tip20p, and Sec39p.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
nuclear envelope	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

Name	Definition
SNARE binding	Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.

Name	Definition
ER-dependent peroxisome organization	A process of peroxisome organization in which assembly or arrangement of constituent parts takes place in the endoplasmic reticulum.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.
vesicle-mediated transport	A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins