Q12663
Gene name |
SAHH |
Protein name |
Adenosylhomocysteinase |
Names |
AdoHcyase, S-adenosyl-L-homocysteine hydrolase |
Species |
Pneumocystis carinii |
KEGG Pathway |
|
EC number |
3.13.2.1: Thioether and trialkylsulfonium hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q12663
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q12663-F1 | Predicted | AlphaFoldDB |
No variants for Q12663
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q12663 | |||||
No associated diseases with Q12663
3 regional properties for Q12663
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | S-adenosyl-L-homocysteine hydrolase, NAD binding domain | 199 - 360 | IPR015878 |
| conserved_site | S-adenosyl-L-homocysteine hydrolase, conserved site | 68 - 82 | IPR020082-1 |
| conserved_site | S-adenosyl-L-homocysteine hydrolase, conserved site | 221 - 237 | IPR020082-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.13.2.1 | Thioether and trialkylsulfonium hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| adenosylhomocysteinase activity | Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| one-carbon metabolic process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| SCRYFLAEWG | RKEIELAENE | MPGLISCRRN | MRFKPLRVQI | AGCLHMTIQT | AVLIETLVEL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GAEVTWSSCN | IFSTQDHAAA | AIAASGISVF | AWKGETEEEY | LWCIETQLTS | FKDGKHLNMI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LDDGGDVTSL | VHNKYPDYLK | NCKGISEETT | TGVHQFYKML | KEGKLKVPAI | NVNDSVTKSK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FDNLYGVSLV | LIYKIISNIK | LRCRESLIDG | IKRATDIMIA | AKVAIVAGFG | DVGKGCAKAL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RGMGARVIIT | EIDPIVALQA | SMEGYQVAVM | EEVADQADIF | VTATGCKDII | CERHFEAMKN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DAIICNIGHF | DVEIDVAWLI | KKCSSISNIK | PQVDRYLLGN | GRNIILLAEG | RLVNLGCATG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HSSMVMSMSF | TNQVLAQIAL | WTAQEGQYPL | GVHFLPKKLD | EEVARLHLSK | LGKLTSLTPE |
| 430 | |||||
| QSAYLDIPID | GPYKSEHYRY |