Q124G2
Gene name |
aceK |
Protein name |
Isocitrate dehydrogenase kinase/phosphatase |
Names |
IDH kinase/phosphatase, IDHK/P |
Species |
Polaromonas sp (strain JS666 / ATCC BAA-500) |
KEGG Pathway |
pol:Bpro_4188 |
EC number |
2.7.11.5: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q124G2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q124G2-F1 | Predicted | AlphaFoldDB |
No variants for Q124G2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q124G2 | |||||
No associated diseases with Q124G2
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.5 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| [isocitrate dehydrogenase (NADP+)] kinase activity | Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| phosphoprotein phosphatase activity | Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| glucose metabolic process | The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. |
| glyoxylate cycle | A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| tricarboxylic acid cycle | A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFPQRLDSTI | AYDIAKAMMD | GFNRHYQLFR | TESARAKHRF | ETADWHGQQR | AQRERIEFYD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LRVREASTRL | EREFKAGEQS | MDVWHQVKLH | YIGLLVNHHQ | PELAETFFNS | VTTKILHRSY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FQNDFIFVRP | AVSTEYIENE | EPTAQPTYRA | YYPTRDNLRE | IIVRLVRDFD | LRLEFEDLER |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DAGYVLEAVS | ERLSDVKLRA | NFQIQVLSGL | FFRNKGAYVV | GKIINGFNEV | PLALPILHSK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SGKLVIDAAL | FGEDDLLILF | SFARAYFMVD | MGIPSAYVQF | LRSMMPHMPR | AEIYNALGLA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KQGKTLFYRD | FLHHLRHSTD | KFRIAPGIKG | MVMLVFDLPS | FPYVFKVIKD | YYPPQKDTSR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EQIKGKYLLV | KQHDRVGRMA | DTQEYSEVAF | PRARFDDELI | AEIEKFAPSQ | LEISDRDRDG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NTEVIIKHVY | IERRMIPLNI | YLQEAFDAGV | GEPAAKNQIE | RAVVEYGNAI | KDLVAANIFP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GDMLWKNFGI | TRHGKVVFYD | YDEIEYITDC | KFRRVPAPRN | DEEEMSGEVW | YSVGPKDVFP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ETFAPFLLGN | DAVREVFMKH | HGDLLDAEFW | QSHQARIQAG | HVHDVFPYER | EKRFTRRHSP |
| 610 | 620 | ||||
| GRNDHELLTH | LPPEPMLTGL | SGMTP |